A 22-year-old female with acute leukemia was admitted to the oncology center for evaluation and treatment. Piperacillin was used during her admission for treatment of Pseudomonal sepsis. The patient's renal and liver function deteriorated during the hospital course, requiring large dose adjustments of piperacillin. The elimination half-life of piperacillin was estimated to be 32 hours. Patients with both liver and renal disease require only small doses of piperacillin to achieve therapeutic plasma concentration.
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GironJAMeyersBRHirschmanSZSrulevitchE. Pharmacokinetics of piperacillin in patients with moderate renal failure and in patients undergoing hemodialysis. Antimicrob Agents Chemother1981; 19: 279–83.
