Personal Adventures in Biopharmaceutical Research during the 1953–1984 Years

BUSSE L.W. , SWINTOSKY J.V. , RIEGELMAN S. Colloids, emulsions, and suspensions. In: Lyman R.A. , ed. American Pharmacy. Philadelphia: Lippincott, 1947: 158–212.

SWINTOSKY J.V. , RiEGELMAN S. , HIGUCHIT Studies on pharmaceutical powders and the state of subdivision. I. The application of low-temperature nitrogen adsorption isotherms to the determination of surface areas. J Am Pharm Assoc 1949; 38: 210–5.

SWINTOSKY J.V. , RIEGELMAN S. , HIGUCHI T. Studies on pharmaceutical powders and the state of subdivision. II. Surface area measurements of some pharmaceutical powders by the low-temperature nitrogen adsorption isotherm technique. J Am Pharm Assoc 1949; 38: 308–13.

SWINTOSKY J.V. , RIEGELMAN S. , HIGUCHI T. Studies on pharmaceutical powders and the state of subdivision. III. An evaluation of pharmaceutical dispensing techniques employed to increase the specific surface areas of powders. J Am Pharm Assoc 1949; 38: 378–81.

RIEGELMAN S. , SWINTOSKY J.V. , HIGUCHI T. Studies on pharmaceutical powders and the state of subdivision. IV. The application of spray-drying techniques to pharmaceutical powders. J Am Pharm Assoc 1950; 39: 444–50.

SWINTOSKY J.V. , RAO A.N. State of subdivision. V. Magnitude and variations in specific surface areas. J Am Pharm Assoc 1952; 41: 441–5.

LINTNER C.J. , SWINTOSKY J.V. , ZUCK D. Electrometric titration of volatile oils and volatile oil isolates using lithium aluminum hydride. J Am Pharm Assoc 1950; 39: 415–7.

HIGUCHI T. , RAO A.N. , BUSSE L.W. The physics of tablet compression. II. The influence of degree of compression on properties of tablets. J Am Pharm Assoc 1953; 42: 194–200.

SWINTOSKY J.V. , KENNON L. A note on the preparation of powdered carboxymethylcellulose and linseed acids. J Am Pharm Assoc 1953; 42: 505.

SWINTOSKY J.V. , KURAMOTO R. , HIGUCHI T. The liquid-liquid countercurrent separation of a menthol-menthyl acetate mixture. J Am Pharm Assoc 1953; 42: 666–8.

LEMBERGER A.P. , HIGUCHI T. , BUSSE L.W. Preparation of some steroids in microcrystalline form by rapid freeze-sublimation technique. J Am Pharm Assoc 1954; 43: 338–41.

FOYE W.O. , LANGE W.E. , SWINTOSKY J.V. Metal chelates of streptomycin. J Am Pharm Assoc 1955; 44: 261–3.

SWINTOSKY J.V. , KENNON L. , TINGSTAD J. Properties and applications of powdered polysaccharide acids. I. Preparation and titration curves. J Am Pharm Assoc 1955; 44: 109–12.

SWINTOSKY J.V. , KENNON L. , TINGSTAD J. Properties and applications of powdered polysaccharide acids. II. Tablet studies. J Am Pharm Assoc 1955; 44: 112–4.

SWINTOSKY J.V. , KAUFMAN A.M. Properties and applications of powdered polysaccharide acids. III. Inhibition of microbial growth by carboxymethylcellulose. J Am Pharm Assoc 1955; 44: 540–2.

SWINTOSKY J.V. , ROSEN E. , ROBINSON M.J. Suppression of penicillin G procaine solubility in aqueous media. J Am Pharm Assoc 1956; 45: 34–7.

SWINTOSKY J.V. , ROSEN E. , ROBINSON M.J. Preparation of oral penicillin G procaine suspensions of extended shelf life. J Am Pharm Assoc 1956; 45: 37–40.

SWINTOSKY J.V. Illustrations and pharmaceutical interpretations of first order drug elimination rate from the bloodstream. J Am Pharm Assoc 1956; 45: 395–400.

FOLTZ E.L. , SWINTOSKY J.V. , ROBINSON M.J. Absorption, distribution and fate of sulfaethylthiadiazole administered orally and intravenously. Fed Proc 1956: 15(1).

SWINTOSKY J.V. Excretion equations and interpretation for digitoxin. Nature 1957; 179: 98–9.

SWINTOSKY J.V. , ROBINSON M.J. , FOLTZ E.L. Sulfaethylthiadiazole I. Interpretations of human blood level concentrations following oral doses. J Am Pharm Assoc 1957; 46: 399–403.

SWINTOSKY J.V. , ROBINSON M.J. , FOLTZ E.L. Sulfaethylthiadiazole II. Distribution and disappearance from the tissues following intravenous injection. J Am Pharm Assoc 1957; 46: 403–11.

SWINTOSKY J.V. , FOLTZ E.L. , BONDI A. Jr Sulfaethylthiadiazole III. Kinetics of absorption, distribution and excretion. J Am Pharm Assoc 1958; 47: 136–141.

KENNON L. , SWINTOSKY J.V. Properties and applications of powdered polysaccharide acids. IV. Tablets studies with HCMC. J Am Pharm Assoc 1958; 47: 396–8.

ERIKSEN S.P. , PAULS J.F. , SWINTOSKY J.V. A mathematical interpretation of the kinetics of elevated temperature stability studies as applied to solid formulations. J Am Pharm Assoc 1958; 47: 697–700.

SWINTOSKY J.V. , BONDI A. Jr , ROBINSON M.J. Sulfaethylthiadiazole IV. Steady state blood concentration and urinary excretion data following repeated oral doses. J Am Pharm Assoc 1958; 47: 753–6.

RAVIN L.J. , KENNON L. , SWINTOSKY J.V. A note on the photosensitivity of phenothiazine derivatives. J Am Pharm Assoc 1958; 47: 760.

ROBINSON M.J. , BONDI A. Jr , SWINTOSKY J.V. Sulfamethylthiadiazole: human blood concentration and urinary excretion data following oral doses. J Am Pharm Assoc 1958; 47: 874–8.

REESE D.R. , FREE S.M. , SWINTOSKY J.V. The effect of dosage forms on the duration and continuity of action of belladonna alkaloids. Am J Dig Dis 1959; 4: 220–8.

ROBINSON M.J. , SWINTOSKY J.V. Sulfaethylthiadiazole V. Design and study of an oral sustained release dosage form. J Am Pharm Assoc 1959; 48: 473–8.

NICHOLSON A.E. , TUCKER S.J. , SWINTOSKY J.V. Sulfaethylthiadiazole VI. Blood and urine concentrations from sustained and immediate release tablets. J Am Pharm Assoc 1960; 49: 40–4.

ERIKSEN S.P. , IRWIN G.M. , SWINTOSKY J.V. Heating and cooling rate coefficients and related factors affecting procedures for tablet shelf life prediction. J Am Pharm Assoc 1960; 49: 632–43.

CHONG C.W. , ERIKSEN S.P. , SWINTOSKY J.V. Antithixothropic behavior of magnesia magma. J Am Pharm Assoc 1960; 49: 547–52.

SWINTOSKY J.V. , BLYTHE R.H. The excretion of free salicylate from an enteric coated tablet and a compressed tablet. Drug Std 1960; 28: 5–8.

REESE D.R. , CHONG C.W. , SWINTOSKY J.V. Physical properties of lipids used in pharmacy I. Screening raw materials via photomicrography. J Am Pharm Assoc 1960; 49: 85–9.

SWINTOSKY J.V. , STURTEVANT F.M. Exponential disappearance of pharmacologic activity. J Am Pharm Assoc 1960; 49: 685–6.

ROSEN E. , SWINTOSKY J.V. Preparation of ³⁵S labeled trimeprazine tartrate sustained action product for its evaluation in man. J Pharm Pharmacol (Supplement) 1960; 12: 237T–44T.

SWINTOSKY J.V. Design of oral sustained-action dosage forms. Drug & Cosmet Ind 1960; 87: 464–8.

SWINTOSKY J.V. Sustained release pharmaceutical tablets. U.S. Patent 2,951,792. Sept. 6, 1960.

REESE D.R. , SWINTOSKY J.V. Novel coating material for medicaments. U.S. Patent 2,921,883. Jan. 19, 1960.

SWINTOSKY J.V. Press coated enteric tablets and process for preparing them. U.S. Patent 2,971,889. Feb. 14, 1961.

ERIKSEN S.P. , SWINTOSKY J.V. , SERF ASS F.J. Equipment and methodology for relating gastrointestinal absorption to site of drug release. J Pharm Sci 1961; 50: 151–6.

REESE D.R. , NORDBERG P.N. , ERIKSEN S.P. , SWINTOSKY J.V. Technique for studying thermally induced phase transitions. J Pharm Sci 1961; 50: 177–8.

SWINTOSKY J.V. Biologic half-life and tissue concentrations. Proceedings of AACP Teachers' Seminar, Madison, Wisconsin. 1961; 13: 140–56.

PORTNOFF J.B. , SWINTOSKY J.V. , KOSTENBAUDER H.B. Control of urine pH and its effect on drug excretion in humans. J Pharm Sci 1961; 50: 890.

KOSTENBAUDER H.B. , PORTNOFF J.B. , SWINTOSKY J.V. Control of urine pH and its effects on sulfaethidole excretion in humans. J Pharm Sci 1962; 51: 1084–9.

ERIKSEN S.P. , REESE D.R. , SWINTOSKY J.V. Physical properties of lipids used in pharmacy II. Use of heating-cooling curves to study lipid materials. J Pharm Sci 1962; 51: 843–50.

SWINTOSKY J.V. Riboflavin marker in drug products. J Pharm Sci 1962; 51: 1015.

ERIKSEN S.P. , IRWIN G.M. , SWINTOSKY J.V. Antacid properties of calcium, magnesium, and aluminum salts of water-insoluble aliphatic acids. J Pharm Sci 1963; 52: 552–6.

SWINTOSKY J.V. Development and design of oral sustained release dosage forms. Indian J Phar 1963; 25: 360–7.

REESE D.R. , IRWIN G.M. , DITTERT L.W. , CHONG C.W. , SWINTOSKY J.V. Drug partitioning I. A non-emulsifying method for measuring distribution coefficients. J Pharm Sci 1964; 53: 591–7.

DOLUISIO J.T. , SWINTOSKY J.V. Drug partitioning II. An in vitro model for drug absorption. J Pharm Sci 1964; 53: 597–601.

SWINTOSKY J.V. 5-(3.4-Carbonyldioxyphenyl)-3-Isopropyl-2-Oxazolidone. U.S. Patent 3,131,197. April 28, 1964.

LIN T.H. , GUARINI J.R. , ERIKSEN S.P. , SWINTOSKY J.V. Effect of site release on the absorption of trimeprazine-³⁵S and Penicillin G in dogs. J Pharm Sci 1964; 53: 1357–9.

SWINTOSKY J.V. Dosage forms providing prolonged drug absorption: their preparation and evaluation. Proceedings of the 84th annual meeting, Japanese Pharmaceutical Society, Tokyo, Japan, April 4–7, 1964: 1–9.

SWINTOSKY J.V. Method of increasing the oil solubility of compounds and products thereof. U.S. Patent 3,172,816. March 9, 1965.

DOLUISIO J.T. , SWINTOSKY J.V. Biopharmaceutics. Am J Phar 1965; 137: 144–68, 175–93.

KUPCHAN S.M. , CASY A.F. , SWINTOSKY J.V. Drug latentiation. Synthesis and preliminary evaluation of testosterone derivatives. J Pharm Sci 1965; 54: 514–24.

DOLUISIO J.T. , SWINTOSKY J.V. Drug partitioning III. Kinetics of drug transfer in an in vitro model for drug absorption. J Pharm Sci 1965; 54: 1594–9.

SWINTOSKY J.V. Bromo- and chloroalkyl 4-acetamidophenyl carbonates. U.S. Patent 3,203,980. Aug. 31, 1965.

SWINTOSKY J.V. , ADAMS H.J. , CALDWELL H.C. Carbonate prodrugs in formulation and therapeutics. J Pharm Sci 1966; 55: 992.

CALDWELL H.C. , ADMS H.J. , RIVARD D.E. Trichloroethyl carbonate I. Synthesis, physical properties and pharmacology. J Pharm Sci 1967; 56: 920–1.

CHONG C.W. , DITTERT L.W. , KOSTENBAUDER H.B. , SWINTOSKY J.V. Titration assembly and experimental procedure for accurate pH stat measurements of substrate hydrolysis rates in blood plasma. J Pharm Sci 1967; 56: 1647–52.

SWINTOSKY J.V. Carbonates and carbamates of 2,2-Dialkyl-1,3-Propanediol-(2,2,2-Trichloroethylcarbonate). U.S. Patent 3,372,181. Mar. 5, 1968.

SWINTOSKY J.V. Alkyl carbonates of salicylic acid. U.S. Patent 3,412,131. Nov. 19, 1968.

SWINTOSKY J.V. , CALDWELL H.C. , CHONG CW# 4-Acetamidophenyl 2,2,2-Trichloroethyl carbonate. Synthesis, physical properties, and in vitro hydrolysis. J Pharm Sci 1968; 57: 752–6.

DITTERT L.W. , CALDWELL H.C. , ADAMS H.J. Acetaminophen prodrugs I. Synthesis, physico-chemical properties, and analgesic activity. J Pharm Sci 1968; 57: 774–80.

DITTERT L.W. , IRWIN G.M. , CHONG C.W. Acetaminophen prodrugs II. Effect of structure and enzyme source on enzymatic and nonenzymatic hydrolysis of carbonate esters. J Pharm Sci 1968; 57: 780–3.

DITTERT L.W. , CALDWELL HC , ELLISON T. Carbonate ester prodrugs of salicylic acid. Synthesis, solubility characteristics, in vitro enzymatic hydrolysis rates, and blood levels of salicylate following oral administration to dogs. J Pharm Sci 1968; 57: 828–31.

DITTERT L.W. , ADAMS H.J. , ALEXANDER F. 4-Acetamidophenyl 2,2,2-trichloroethyl carbonate. Particle size studies in animals and man. J Pharm Sci 1968; 57: 1146–51.

DITTERT L.W. , ADAMS H.J. , CHONG C.W. Trichloroethyl carbonate. Influence of particle size on oral toxicity in mice. J Pharm Sci 1968; 57: 1269–70.

IRWIN G.M. , KOSTENBAUDER H.B. , DITTERT L.W. Enhancement of gastrointestinal absorption of a quaternary ammonium compound by trichloroacetate. J Pharm Sci 1969; 58: 313–5.

DITTERT L.W. , IRWIN G.M. , RATTIE E.S. Hydrolysis of 4-acetamidophenyl 2,2,2-trichloroethyl carbonate by esterolytic enzymes from various sources. J Pharm Sci 1969; 58: 557–9.

SWINTOSKY J.V. , DITTERT L.W. , DOLUISIO J.T. Estimation of drug absorption rates from blood concentration profiles. Am J Hosp Pharm 1969; 26: 519–22.

DOLUISIO J.T. , BILLUPS N.F. , DITTERT L.W. Drug absorption I: an in situ rat gut technique yielding realistic absorption rates. J Pharm Sci 1969; 58: 1196–1200.

SWINTOSKY J.V. Novel chloro and bromoalkyl carbonates of salicylic acid. U.S. Patent 3,499,023. March 3, 1970.

DOLUISIO J.T. , CROUTHAMEL G.H. , SWINTOSKY J.V. Drug absorption III. The effect of membrane storage on the kinetics of drug absorption. J Pharm Sci 1970; 59: 72–6.

RATTIE E.S. , SHAMI E.G. , DITTERT L.W. Acetaminophen prodrugs III: Hydrolysis of carbonate and carboxylic acid esters in aqueous buffers. J Pharm Sci 1970; 59: 1738–41.

SWINTOSKY J.V. Sulfonamides and their use in urinary tract infections: some biopharmaceutical considerations. Medical seminar conference report, Foresta Hotel, Stockholm, Sweden, March 1971.

CALDWELL H.C. , ADAMS H.J. , JONES R.G. Enamine prodrugs. J Pharm Sci 1971; 60: 1810–2.

DITTERT L.W. , SWINTOSKY J.V. Types of data required to make judgments on bioavailability. Australian J Pharm Sci 1974; NS3: 1–8.

DIGENIS G.A. , AMOS H.E. , YANG K. Methionine substitutes in ruminant nutrition I: Stability of nitrogenous compounds related to methionine during in vitro incubation with rumen microorganisms. J Pharm Sci 1974; 63: 745–51.

DIGENIS G.A. , AMOS H.E. , MITCHELL G.E. Methionine substitutes in ruminant nutrition II: stability of non-nitrogenous compounds related to methionine during in vitro incubation with rumen microorganisms. J Pharm Sci 1974; 63: 751–4.

DIGENIS G.A. , Swintosky J.V. Drug latentiation. In: Gillette J.R. , Brodie B.B. , eds. Handbook of experimental pharmacology (concepts in biochemical pharmacology). Berlin, New York: Springer-Verlag, 1975: 86–112.

AMOS H.E. , SCHELLING G.T. , DIGENIS G.A. Methionine replacement value of N-Acetyl methionine and homocysteine thiolac-tone HCl for growing rats. J Nutr 1975; 105: 577–80.

KOSTENBAUDER H.B. , SWINTOSKY J.V. Biopharmacy theory and practice. Journal of the Hungarian Pharmaceutical Society, (Gyogyszereszet) 1977; 21: 361–9.

SWINTOSKY J.V. , POGONOWSKA-WALA E. The in situ rat gut technique. A simple, rapid, inexpensive way to study factors influencing drug absorption rate from the intestine. Pharmacy International 1982; 3: 163–7.

SWINTOSKY J.V. , POGONOWSKA-WALA E. The in situ rat gut technique (letter). Pharmacy International 1983; 4: 117.

SWINTOSKY J.V. Personal experiences in the early days of biopharmacy and pharmacokinetics. In: Pharmacokinetics-a modern view. New York: Plenum, 1984: 37–54.

SWINTOSKY J.V. , FOSTER T.S. , TRUELOVE J.E. Comparative safety and plasma salicylate profiles of aspirin and the hexylcarbonate prodrug of salicylic acid in man. Curr Ther Res 1984; 36: 792–6.

SWINTOSKY J.V. , POGONOWSKA-WALA E. Studies done in single rats, simultaneously comparing absorption rates from upper and lower segments of the small intestine. Drug Dev Indus Pharm (accepted for publication).

SWINTOSKY J.V. , POGONOWSKA-WALA E. Students' experiment in pharmacodynamics: utilization of the in situ rat gut technique for the study of absorption rates of a series of structurally related compounds (submitted for publication).