Comment on Mitoxantrone

Fenoglio JJ Jr . The effects of drugs on the cardiovascular system. In: Silver MD , ed. Cardiovasc Pathol 1983; 2:1085–107.

Adamson RH . Daunomycin (NSC — 8215) and Adriamycin (NSC — 123127) hypothesis concerning antitumor activity and cardiotoxicity. Cancer Chemother Rep 1974; 58:293–4.

Kharasch ED Novak RF . Inhibitions of Adriamycin simulated microsomal lipid peroxidation of mitoxantrone and ametantrone, two new anthracenedione, antineoplastic agents. Biochem Biophys Res Commun 1982; 108:1346–52.

Minmaugh EG Trush MA Ginsburg E Gram TE . Differential effects of anthracycline drugs on rat heart and liver microsomal reduced nicotinamide adenine dinucleotide phosphate-dependent lipid peroxidation. Cancer Res 1982; 42:3574–82.

Doroshow JH . Anthracycline antibiotic-stimulated superoxide, hydrogen peroxide, and hydroxyl radical production by NADH dehydrogenase. Cancer Res 1983; 43:4543–51.

Doroshow JH Davies KJA . Comparative cardiac oxygen radical metabolism by anthracycline antibiotics, mitoxantrone, bisantrene, 4 ′-(-9-acridinylamino)-methanesulfon-M-anisidide and neocarzinostatin. Biochem Pharmacol 1983; 32:2935–9.

Sparano BM Gordon G Hall C Iatropoulos MJ Noble JF . Safety assessment of a new anticancer compound, mitoxantrone, in beagle dogs: Comparison with doxorubicin II. Histologic and ultrastructural pathology. Cancer Treat Rep 1982; 66:1145–58.

Iatropoulos MJ . Anthracycline cardiomyopathy: Predictive value of animal models. Cancer Treat Symp 1984; 3:380–7.

Von Hoff DD Layard MW Basa P , Risk factors for drug induced congestive heart failure. Ann Intern Med 1979; 91:710–7.

Dukart G . Cardiac episodes in patients receiving mitoxantrone. In: Smyth JF , ed. Pharmanual, a comprehensive guide to the therapeutic use of Novantrone. Chicago: Pharma Libri, 1984 (in press).

Henderson IC Dukart G . A randomized trial comparing mitoxantrone (M) with doxorubicin (D) in patients (pts) with metastatic breast cancer (BC). Poster (C-470) presented at the American Society of Clinical Oncology meeting in Toronto, May 1984.

Alexander J Daniak N Berger HJ , Serial assessment of doxorubicin cardiotoxicity with quantitative radionuclide angiography. N Engl J Med 1979; 300:278–83.

Benjamin RS Chawla SP Ewer MS , Evaluation of mitoxantrone cardiac toxicity by nuclear angiography and endomyocardial biopsy. Presented (C-156) at the American Society of Clinical Oncology meeting in Toronto, May 1984.