The antiemetic activity of escalating doses of droperidol was evaluated in ten patients undergoing chemotherapy with cisplatin regimens. Major antiemetic activity was achieved in five patients, two patients had less nausea and vomiting as compared with prior prochlorperazine therapy, and three patients were refractory to droperidol. No dose-response relationship was observed. Sedation occurred in nine patients, and two patients experienced dystonic reactions. Droperidol is a relatively safe and effective antiemetic for patients undergoing chemotherapy with cisplatin.
GRALLAR.J., BRAUNT.J., SQUILLANTEA.Metoclopramide: initial clinical studies of high-dosage regimens in cisplatin induced emesis. In: PosterD., PentaJ., BrunoS., eds. Treatment of cancer chemotherapy-induced nausea and vomiting.New York: Masson Publishing, 1981: 167–76.
6.
GRALLAR.J., ITRIL.M., PISKOS.E.Antiemetic efficacy of high-dose metoclopramide: randomized trials with placebo and prochlorperazine in patients with chemotherapy induced nausea and vomiting. N Engl J Med1981; 305: 905–9.
7.
Package insert.Inapsine.Janssen Pharmaceutica, New Brunswick, NJ, March, 1980.
IWAMOTOK., SCHWARTZH.Antiemetic effect of droperidol after ophthalmic surgery. Arch Ophthalmol1978; 96: 1378–9.
10.
WINNINGT.J., BROCK-UTNEJ.G., DOWNINGJ.W.Nausea and vomiting after anesthesia and minor surgery. Anesth Analg (Cleve)1977; 56: 674–7.
11.
LOESERE.A., BENNETTG., STANLEYT.H.Comparison of droperidol, haloperidol, and prochlorperazine and postoperative antiemetics. Can Anesth Soc J1979; 26: 125–7.
12.
GROSSMANB., LESSINL.S., COHENP.Droperidol prevents nausea and vomiting from cis-platinum (letter). N Engl J Med1979; 301: 47.
13.
JACOBSA.J., DEPPEG., COHENC.T.A comparison of the antiemetic effects of droperidol and prochlorperazine in chemotherapy with cis-platinum. Gynecol Oncol1980; 10: 55–7.
14.
PALADINEW., PRICEL., SOKOLG.Antiemetic trial of droperidol. Proc Am Soc Clin Oncol1980; 21: 381.
15.
WILSONJ., WELTZD., SOLIMANDOD.Continuous infusion droperidol: antiemetic therapy for cis-platinum (DDP) toxicity. Proc Am Soc Clin Oncol1981; 22: 421.
16.
BROWNR.E., GREGGR.E., HOODJ.C.Droperidol treatment of streptozotocin-induced nausea and vomiting. Drug Intell Clin Pharm1982; 16: 775–6.
17.
ARROWSMITHJ., GAMSR.Dystonia with droperidol therapy (letter). N Engl J Med1981; 305: 227.
