Chlorpropamide-Induced Hemolytic Anemia

Abstract

Acute intravascular hemolysis developed when a diabetic patient, previously treated with glyburide, was started on another oral sulfonylurea drug, chlorpropamide.

Immunoglobulins were not found in the patient's serum and the red cells were coated with C₃ only, suggesting an “innocent bystander” reaction. This case demonstrates that there is no cross reactivity between glyburide and chlorpropamide in producing hemolytic anemia.