Abstract
A 50-year-old black female developed hepatic dysfunction secondary to captopril therapy, 25 mg tid for one month. Liver biopsy showed primarily cholestasis, with secondary hepatocellular elements. Symptoms consisted of jaundice, pruritus, anorexia and weight loss, hepatomegaly, and abdominal tenderness. Total bilirubin, alkaline phosphatase, lactate dehydrogenase (LDH), and serum glutamic-oxaloacetic transaminase (SGOT), reached highs of 506 μmol/L, 737 U/L, 319 U/L, and 100 U/L, respectively. Recovery was slow, but complete, after discontinuation of the drug.
Get full access to this article
View all access options for this article.
References
1.
Vidt
DG
Bravo
EL
Fouad
FM
. Drug therapy: Captopril . N Engl J Med
1983 ; 306 : 214 –9 .
2.
Ram
CVS
. Captopril . Arch Intern Med
1982 ; 142 : 914 –6 .
3.
Harris
C
Smith
GH
. Captopril evaluation . Drug Intell Clin Pharm
1981 ; 15 : 932 –9 .
4.
Romankiewicz
JA
Brogden
RN
Heel
RC
Captopril: An update review of is pharmacological properties and therapeutic efficacy in congestive heart failure . Drugs
1983 ; 25 : 6 –40 .
5.
Vandenburg
M
Parfrey
P
Wright
P
Hepatitis associated with captopril treatment . Br J Clin Pharmacol
1981 ; 11 : 105 –6 .
6.
Ryckelynck
JPH
Batho
J
Peny
J
Hepatitis due to captopril . Nouv Presse Med
1982 ; 11 : 1950 –1 .
7.
deLigny
BH
Mariot
A
Kessler
M
Hepatitis during multi-therapy and captopril treatment . Therapie
1982 ; 37 : 688 –9 .
8.
Drerup
AL
Alexander
WA
Lamb
GD
Jaundice occurring in a patient treated with chlorothiazide . N Engl J Med
1958 ; 259 : 534 –6 .
9.
Husebye
KO
. Jaundice with persisting pericholangiolitic inflammation in a patient treated with chlorothiazide . Am J Dig Dis
1964 ; 9 : 439 –45 .
10.
Kowlessar
OD
. Acute pancreatitis . In:
Beeson
PB
McDermott
W
, eds. Textbook of medicine . Philadelphia : WB Saunders , 1975 : 1246 .