Nomifensine is an isoquinoline antidepressant that inhibits the reuptake of dopamine at central synapses. It also inhibits norepinephrine reuptake but is only a weak inhibitor of 5-hydroxytryptamine. Open and controlled trials comparing nomifensine with placebo and other standard antidepressants have shown it to be an effective antidepressant in divided doses up to 200 mg/d. The full dosage range of 50–200 mg/d is well tolerated, and doses can be selected to suit patient disease, age, and therapeutic response. Minimal anticholinergic and sedative side effects and no impairment of psychomotor performance make nomifensine a suitable drug for use in a wide variety of ambulatory outpatients, including the elderly. A relative lack of cardiotoxicity and epileptogenic activity add to this profile; the safety of the drug, when taken in overdose, has been documented. However, the place of nomifensine in the treatment of depression, relative to other antidepressants, is still unclear.
StonierPDWittelsPY. Clinical profile of nomifensine. In: StonierPDJennerFA, eds. Nomifensine. Proceedings of the international congress and symposium. London, December 1979. New York: Grune and Stratton, 1980: 131–40.
2.
HoffmanI.A comparative review of the pharmacology of nomifensine. Br J Clin Pharmacol1977; 4: 69–79S.
3.
BraestrupCScheel-KrugerJ.Methylphenidate-like effects of the antidepressant drug nomifensine (HOE 984). Eur J Pharmacol1976; 38: 305–12.
4.
CostallBNaylorRJ. A comparison of circling models for the detection of antiparkinson activity. Psychopharmacology (Berlin)1975; 41: 57–64.
5.
HindmarchIParrotAC. Repeated dose comparison of nomifensine, imipramine and placebo on subjective assessments of sleep and objective measures of psychomotor performance. Br J Clin Pharmacol1977; 4: 167–73S.
6.
PorathUSchreierK.On the use of nomifensine in depressive mood in children and young people. In: Alival Symposium uber Ergebnisse der experimentellen and klinischen Prufung. Stuttgart: Schattauer, 1977: 39–45.
7.
DawlingSBraithwaiteRACromeP.Nomifensine overdose and plasma drug concentration. Lancet1979; 1: 56.
VohraJKBurrowsGDMcIntyreIDaviesB.Cardiovascular effects of nomifensine. Lancet1978; 2: 902–3.
10.
ChanMYEhsanullahRWadsworthJMcEwenJ.A comparison of the pharmacodynamic profiles of nomifensine and amitriptyline in normal subjects. Br J Clin Pharmacol1980; 9: 247.
11.
MalschU.An investigation to assess the anticholinergic and acute psychotropic effect of nomifensine. In: Alival Symposium uber Ergebnisse der experimentellen and klinischen Prufung. Stuttgart: Schattauer, 1977: 141.
12.
CostallBNaylorRJ. Later aspects of nomifensine pharmacology. Br J Clin Pharmacol1977; 4: 89–99S.
13.
ParkDMFindleyLJTeychennePF. Nomifensine in parkinsonism. Br J Clin Pharmacol1977; 4: 185–6S.
CamanniFGenazzaniARMassaraF.Prolactin responsiveness to nomifensine in patients with hyperprolactinemia of tumorous or uncertain etiology. J Clin Endocrinol Metab1981; 51: 650–3.
16.
MullerEEGenazzaniARMurruS.Nomifensine: Diagnostic test in hyperprolactinemic states. J Clin Endocrinol Metab1978; 47: 1352.
17.
DunneMJWalkerJCowdenEARatcliffeJG. Nomifensine test for investigation of hyperprolactinemia. Lancet1979; 2: 1243.
18.
HeptnerWBadianMJBaudnerS, Determination of nomifensine by a sensitive radioimmunoassay. Br J Clin Pharmacol1977; 4: 123–7S.
19.
ChamberlainJHillHM. A simple gas chromatographic method for the determination of nomifensine in plasma and a comparison of the method with other available techniques. Br J Clin Pharmacol1977; 4: 117–21S.
20.
VereczkeyLBianchettiGGarattiniSMorselliPL. Pharmacokinetics of nomifensine in man. Psychopharmacology (Berlin)1975; 45: 225–7.
21.
BrogdenRNHeelRCSpeightTMAveryGS. Nomifensine: A review of its pharmacological properties and therapeutic efficacy. Drugs1979; 18: 1–24.
22.
McIntyreIBurrowsGDNormanTRScoggsBA. Radioimmunoassay of a new antidepressant nomifensine. Presented at ASCEP meeting, 1978, Melbourne, Australia.
23.
HeptnerWHornkeICavagnaF, Metabolism of nomifensine in man and animal species. Arzneim Forsch1978; 28: 58–64.
24.
DawlingSBraithwaiteR.Analytical measurement and pharmacokinetics of nomifensine. In: StonierPDJennerFA, eds. Nomifensine. Proceedings of the international congress and symposium. London, December 1979. New York: Grune and Stratton, 1980: 39–45.
25.
SaletuBTaueberK.Serum levels of nomifensine and pharmacodynamics assessed by the computer-pharmaco-EEG. In: StonierPDJennerFA, eds. Nomifensine. Proceedings of the international congress and symposium. London, December 1979. New York: Grune and Stratton, 1980: 31–8.
26.
BergenerMHesseCHummelF, Contributions on the pharmacokinetics and clinical effectiveness of nomifensine. In: Alival Symposium uber Ergebnisse der experimentellen und klinischen Prufung. Stuttgart: Schattauer, 1977: 273–84.
27.
RingoirSLameireNMunchM, Pharmacokinetics of nomifensine in impaired renal function. Br J Clin Pharmacol1977; 4: 129–34S.
28.
FeighnerJPRobinsEGuzeJB, Diagnostic criteria for use in psychiatric research. Arch Gen Psychiatry1972; 26: 57–63.
29.
BrucknerGWJansenW.Nomifensine: Anwendung bei alter Depression. In: Alival Symposium uber Ergebnisse der experimentellen und klinischen Prufung. Stuttgart: Schattauer, 1977: 273–84.
30.
EckmannF.Klinische Untersuchungen mit dem Antidepressivum Nomifensine. In: Walcher, ed. Systematization, provocation and therapy of depressive psychoses. Vienna: Hollinek, 1974: 199.
31.
KrogerR.Bericht uber einen doppelblind Vergleich zwischen Nomifensine und Placebo: Wirkungweis bei endogenous und involuntiven Depressionen. In: Alival Symposium uber Ergebnisse der experimentellen und klinischen Prufung. Stuttgart: Schattauer, 1977: 207.
32.
MatzRS. Clinical trials with nomifensine in the USA. In: StonierPDJennerFA, eds. Nomifensine. Proceedings of the international congress and symposium. London, December 1979. New York: Grune and Stratton, 1980: 73–80.
33.
ForrestANicholsonP.Controlled randomized group comparison of nomifensine and imipramine in depressive illness. Br J Clin Pharmacol1977; 4: 215–20S.
34.
Medical Research Council Report.Report to the Medical Research Council by its Clinical Psychiatry Committee: Clinical trial of the treatment of depressive illness. Br Med J1965; 1: 881–6.
35.
McCawleyA.Double blind evaluation of nomifensine and imipramine in depressed patients. Am J Psychiatry1979; 136: 841–3.
36.
WoggonBAngstJ.Comparative efficacy of nomifensine and imipramine. Psychopharmacol Bull1979; 15: 29–31.
37.
StorerDEastwoodPBaileyE.Long-term comparison of nomifensine and imipramine in the treatment of depression. In: StonierPDJennerFA, eds. Nomifensine. Proceedings of the international congress and symposium. London, December 1979. New York: Grune and Stratton, 1980: 109–15.
38.
GrofPSaxenaBDaigleLMahutteG.Dopaminergic agonist nomifensine compared with amitriptyline. A double-blind trial in acute primary depressions. Br J Clin Pharmacol1977; 4: 221–5S.
39.
HartmanMHanksGW. A double-blind comparison of nomifensine and amitriptyline. In: StonierPDJennerFA, eds. Nomifensine. Proceedings of the international congress and symposium. London, December 1979. New York: Grune and Stratton, 1980: 117–22.
40.
MontgomerySARoyDRaniJS, A comparative clinical study of nomifensine, mianserin, and imipramine. In: StonierPDJennerFA, eds. Nomifensine. Proceedings of the international congress and symposium. London, December 1979. New York: Grune and Stratton, 1980: 81–5.
41.
BogieWHewettAJBairdCM. Multi-centre clinical comparison of nomifensine, maprotiline, and imipramine in depressed patients in general practice. In: StonierPDJennerFA, eds. Nomifensine. Proceedings of the international congress and symposium. London, December 1979. New York: Grune and Stratton, 1980: 95–101.
42.
NashRJ. Overview of nomifensine maleate antidepressant studies in the U.S. Psychopharmacol Bull1980; 16: 46–7.
43.
MontgomerySA. Maprotiline, nomifensine, mianserin, zimelidine: A review of antidepressant efficacy in inpatients. Neuropharmacology1980; 19: 1185–90.
44.
CromePShandS.The clinical toxicology of nomifensine: Comparison with tricyclic antidepressants. In: StonierPDJennerFA, eds. Nomifensine. Proceedings of the international congress and symposium. London, December 1979. New York: Grune and Stratton, 1980: 55–8.
45.
DawlingSBraithwaiteRACromeP.Nomifensine overdose and plasma drug concentration. Lancet1979; 1: 56.
46.
TaueberK.Relevance of screening tests in human psychopharmacology: The physiological point of view. Symposia Medica Hoechst1974; 10: 51.
47.
FleckensteinG.Nomifensine in general practice: Results of a field study. In: Alival Symposium uber Ergebnesse der experimentellen und klinischen Prufung. Stuttgart: Schattauer, 1977: 301.
48.
BurgessCDWadsworthJMontgomerySTurnerP.Cardiovascular effects of amitriptyline, mianserin, zimelidine, and nomifensine in depressed patients. Postgrad Med J1979; 55: 704–8.
49.
MontgomerySTaylorDJ. Cardiac effect of nomifensine, imipramine, and amitriptyline in depressed patients. In: StonierPDJennerFA, eds. Nomifensine. Proceedings of the international congress and symposium. London, December 1979. New York: Grune and Stratton, 1980: 23–9.
50.
NawishySTrimbleMRRichensA.Antidepressants and epilepsy: The place of nomifensine. In: StonierPDJennerFA, eds. Nomifensine. Proceedings of the international congress and symposium. London, December 1979. New York: Grune and Stratton, 1980: 11–16.
51.
HindmarchIParrotACStonierPD. The effects of nomifensine and HOE 8476 on car driving and related psychomotor performance. In: StonierPDJennerFA, eds. Nomifensine. Proceedings of the international congress and symposium. London, December 1979. New York: Grune and Stratton, 1980: 47–54.
PrescottLFIllingworthRNCritchleyJAJH, Acute haemolysis and renal failure after nomifensine overdosage. Br Med J1980; 281: 1392–3.
54.
RuppWHeptnerWUihleinMBenderRTaueberK.Kinetic interaction of nomifensine with a 1,5 benzodiazepine. Br J Clin Pharmacol1977; 4: 143–6S.
55.
TaueberK.Comparison of nomifensine and placebo. Br J Clin Pharmacol1977; 4: 209–13S.
56.
HanksGWMagnusRVMyskovaIMathurG.Antidepressants in single daily doses: Studies with nomifensine. In: StonierPDJennerFA, eds. Nomifensine. Proceedings of the international congress and symposium. London, December 1979. New York: Grune and Stratton, 1980: 87–94.
