Frozen Storage and Microwave Thawing of Parenteral Nutrition Solutions in Plastic Containers

Abstract

Amino acid-dextrose solutions for parenteral nutrition in flexible plastic containers can be stored for prolonged periods at — 20°C and then thawed immediately before anticipated use in a microwave oven. The purpose of this study was to demonstrate that neither exposure to low temperatures nor microwave energy affects the integrity of the solution components. We have demonstrated that this concept can be applied to the development of an efficient, pharmacy-based parenteral nutrition admixture program, unfettered by constraints of production limitations and the requirements for infusion of admixtures within 24 hours of preparation. Some cost savings may accrue.