The blood pressure of a 36-year-old male with malignant hypertension could not be controlled adequately by as many as eight concurrent oral and parenteral antihypertensive agents administered over a three-week period. These agents included the potent vasodilating agent minoxidil. Only after the initiation of captopril, an oral angiotensin converting enzyme inhibitor, was his blood pressure normalized.
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References
1.
GiffordRWTaraziRC.Resistant hypertension — diagnosis and management. Ann Intern Med1978; 88: 661–5.
2.
PettingerWAMitchellHC.Minoxidil — an alternative to nephrectomy for refractory hypertension. N Engl J Med1973; 289: 167–71.
3.
MehtaPKBashirMShanskyRMSevere hypertension — treatment with minoxidil. JAMA1975; 233: 249–52.
4.
TifftCPGavrasHKershawGRConverting enzyme inhibition in hypertensive emergencies. Ann Intern Med1979; 90: 43–7.
5.
DranovJSkylerJS, Gunnells. Malignant hypertension — current modes of therapy. Arch Intern Med1975; 133: 249–52.
6.
KeithTA.Hypertension crisis — recognition and management. JAMA1977; 237: 1570–7.
7.
GavrasHBrunnerHRTuriniGAAntihypertensive effect of the oral angiotensin-converting enzyme inhibitor SQ 14225 in man. N Engl J Med1978; 298: 991–5.
8.
BrunnerHGavrasHWaeberBOral angiotensin-converting enzyme inhibitor in long-term treatment of hypertensive patients. Ann Intern Med1979; 90: 19–23.
