Abstract
Abstract
French
Seven cases of intravenous methylphenidate abuse are reviewed. A dramatic increase in absolute eosinophil count is noted, which decreases after discontinuation of the drug. Frequent associated complaints are pulmonary symptoms and fevers. The etiology of the eosinophilia is unknown. Mechanisms may include a hypersensitivity reaction to methylphenidate or an allergic reaction to the tablet fillers or diluents. The eosinophilia appears to resolve without complications.
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References
1.
Hahn
HH
Schweid
AI
Beaty
HN
, Complications of injecting dissolved methylphenidate tablets . Arch Intern Med
1969 ; 123 : 656 –9 .
2.
Hopkins
GB
Taylor
DG
, Pulmonary talc granulomatosis . Am Rev Respir Dis
1970 ; 101 : 101 –4 .
3.
Lewman
LV
, Fatal pulmonary hypertension from intravenous injection of methylphenidate (Ritalin®) tablets . Hum Pathol
1972 ; 3 : 67 –70 .
4.
Atlee
WE
, Talc and cornstarch emboli in eyes of drug abusers . JAMA
1972 ; 219 : 49 –51 .
5.
Spensley
J
Rockwell
DA
, Psychosis during methylphendiate abuse
N Engl J Med
1972 ; 286 : 880 –1 .
6.
Miyao
TE
Kern
JW
Gill
MA
Tammelin
BR
, Eosinophilia and intravenous methylphenidate (Ritalin®) abuse . Drug Intell Clin Pharm
1978 ; 12 : 530 –2 .
7.
Wolfe
J
Fein
A.
Fehrenbacher
L.
Eosinophilic syndrome with methylphendiate abuse . Ann Intern Med
1978 ; 89 : 244 –5 .
8.
Mayron
LW
Ailing
S
Kaplan
E.
Eosinophilia and drug abuse . Ann Allergy
1972 ; 30 : 632 –7 .
9.
Rothschild
CJ
Nichol
H.
Allergic reactions to methylphenidate . Can Med Assoc J
1972 ; 106 : 1064 .
10.
Sverd
J
Hurwic
MJ
David
O
Winsberg
BG
, Hypersensitivity to methylphenidate and dextroamphetamine: A report of two cases . Pediatrics
1977 ; 59 : 115 –7 .
11.
Citron
BP
Halpern
M
McCarron
M
, Necrotizing angiitis associated with drug abuse . N Engl J Med
1970 ; 283 : 1003 –11 .
