The area under the plasma concentration curve (AUC) was measured after an intragastric administration of either plain or buffered acetylsalicylic acid, using either an intermittent sampling, or the recently introduced constant blood withdrawal method. Six dogs were used in each study. The AUC by the constant withdrawal method was significantly higher than the AUC by the intermittent sampling method. There was no significant difference between the AUC of the plain and buffered acetylsalicylic acid. The higher AUC by the constant withdrawal method was attributed to the inclusion of the initial plasma levels, which is an inherent advantage of the constant blood withdrawal method.
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