Drug Evaluation Data

Lopressor®, Brand of Metoprolol Tartrate, Company Drug Literature, Geigy Pharmaceuticals, August, 1978.

Davies J. C. : A Review of Beta-Blockers and Their Use in General Practice, J. Royal Coll. Gen. Pract. 26: 219–226, 1976.

Lefkowitz R. J. : Beta-Adrenergic Receptors: Recognition and Regulation, N. Engl. J. Med. 295: 323–328 (Aug. 5) 1976.

Ablad B. Carlsson E. Dahlof C. Ek L. : Some Aspects of the Pharmacology of Adrenergic Beta-Receptor Blockers, In Berglund G. Hansson L. Werko L. (Eds.): Pathophysiology and Management of Arterial Hypertension, Lindgren and Soner Publications, pp. 152–167, 1975.

Ablad B. Borg K. O. Carlsson E. : A Survey of the Pharmacological Properties of Metoprolol in Animals and Man, Acta Pharmacol. Toxicol. 36: (Suppl. 5) 7–23, 1975.

Brogden R. N. Heel R. C. Speight T. M. Avery G. S. : Metoprolol: A Review of its Pharmacological Properties and Therapeutic Efficacy in Hypertension, Drugs 14: 321–348, 1977.

Gordon R. D. : Effects of β-Adrenoreceptor Blocking Drugs on Plasma Volume, Renin and Aldosterone as Components of Their Antihypertensive Action, Drugs 11: (Suppl. 1) 156–163, 1976.

Stenberg J. Wasir H. Amery A. Sannerstedt R. Werko L. : Comparative Hemodynamic Studies in Man of Adrenergic β₁-receptor Agents Without or With Intrinsic Sympathomimetic Activity, Acta Pharmacol. Toxicol. 36: (Suppl. 5) 76–84, 1975.

Johnsson G. Nyberg G. Solvell L. : Influence of Metoprolol and Propranolol on Hemodynamic Effects Induced by Physical Work and Isoprenaline, Acta Pharmacol. Toxicol. 36: (Suppl. 5) 69–75, 1975.

Johnsson G. : Influence of Metoprolol and Propranolol of Hemodynamic Effects Induced by Adrenaline and Physical Work, Acta Pharmacol. Toxicol. 36:(Suppl. 5) 59–68, 1975.

Herwaarden C. L. A. Binkhorst R. A. Fennis J. F. M. Van't Laar A. : Effects of Adrenaline During Treatment With Propranolol and Metoprolol, Br. Med. J. 1: 1029 (Apr. 16), 1977.

Newman R. J. : Comparison of Propranolol, Metoprolol and Acebutolol on Insulin-Induced Hypoglycemia, Br. Med. J. 2: 447–449 (Aug. 21) 1976.

Davidson N. M. : Observations in Man of Hypoglycemia During Selective and Non-Selective Beta-Blockade, Scot. Med. J. 22: 69–72 (Jan.) 1977.

Smith U. Lager I. : Beta Blockade in Diabetes, N. Engl. J. Med. 299: 1467 (Dec. 28) 1978.

Waal-Manning H. J. : Metabolic Effects of β-Adrenoceptor Blockers, Drugs 12: (Suppl. 1) 121–129, 1976.

Lager I. Blohme G. Smith U. : Effect of Cardioselective and Non-selective β-Blockade on the Hypoglycemic Response in Insulin-Dependent Diabetics, Lancet 1: 458–462 (Mar. 3) 1979.

Wright A. D. Barber S. G. Kendall M. J. Poole P. H. : Beta-Adrenoceptor-Blocking Drugs and Blood Sugar Control in Diabetes Mellitus, Brit. Med. J. 1: 159–161 (Jan. 20) 1979.

Regardh L. G. Johnsson G. Jordo L. Solvell L. : Comparative Bioavailability and Effect Studies on Metoprolol Administered as Ordinary and Slow-Release Tablets in Single and Multiple Doses, Acta Pharmacol. Toxicol. 36: (Suppl. 5) 45–58, 1975.

vonBahr C. Collste P. Frisk-Holmberg M. : Plasma Levels and Effects of Metoprolol on Blood Pressure, Adrenergic Beta Receptor Blockade, and Plasma Renin Activity in Essential Hypertension, Clin. Pharmacol. Ther. 20: 130–137 (Aug.) 1976.

Rehardh C. G. Borg K. O. Johansson R. Johnsson G. Plamer L. : Pharmacokinetic Studies on the Selective β₁-Receptor Antagonist Metoprolol in Man, J. Pharmacokinet. Biopharm. 2: 347–364 (Aug.) 1974.

Johnsson G. Regardh C. G. Sulvell L. : Combined Pharmacokinetic and Pharmacodynamic Studies in Man of the Adrenergic β₁-Receptor Antagonist Metoprolol, Acta Pharmacol. Toxicol. 36: (Suppl. 5) 31–44, 1975.

Melander A. Danielson K. Schersten B. Waklen E. : Enhancement of the Bioavailability of Propranolol and Metoprolol by Food, Clin. Pharmacol. Ther. 22: 108–112 (July) 1977.

Appelgren C. Borg K. O. Elofsson R. Johansson K. A. : Binding of Adrenergic Beta-Receptor Antagonists to Human Serum Albumin, Acta Pharm. Suec. 11: 325–332, 1974.

Borg K. O. Carlsson E. Hoffmann K. J. : Metabolism of Metoprolol - (₃H) in Man, the Dog and the Rat, Acta Pharmacol. Toxicol. 36: (Suppl. 5) 125–135, 1975.

Wood A. J. : Cerebrospinal Fluid Concentration of Metoprolol in a Hypertensive Patient, Br. J. Clin. Pharmacol. 4: 240–241 (Apr.) 1977.

Wan S. K. Maronde R. F. : Correlation of the Blood and Salivary Levels of the Beta-One Blocker Metoprolol, Clin. Pharmacol. Ther. 21:(Abstr.) 122 (Jan.) 1977.

Ervik M. : Quantitative Determination of Metoprolol in Plasma and Urine by Gas Chromatography, Acta Pharmacol. Toxicol. 36: (Suppl. 5) 136–144, 1975.

Wan S. H. Maronde R. F. Matin S. B. : GLC Determination of Atenolol and β-Blocking Agents in Biological Fluids, J. Pharm. Sci. 67: 1340–1342 (Sept.) 1978.

Johnsson G. Regardh C. G. : Clinical Pharmacokinetics of β-Adrenoreceptor Blockers, Clin. Pharmacokinet. 11: (Suppl. 11) 111–121, 1976.

Kutti J. Bergstrom A. L. Londborg P. : Platelet Count After Selective Beta-Receptor Blockade, N. Engl. J. Med. 295: 1079 (Nov. 14) 1976.

Moller B. H. J. : Massive Intoxication with Metoprolol, Br. Med. J. 1: 222 (Jan. 24) 1976.

Sire S. : Metoprolol Intoxication, Lancet 2: 1137 (Nov. 20) 1976.

Tivenius L. : Effects of Multiple Doses of Metoprolol and Propranolol on Ventilatory Function in Patients with Chronic Obstructive Lung Disease, Scand. J. Resp. Dis. 57: 190–196, 1976.

Skinner C. Gaddie J. Plamer K. N. V. : Comparison of Effects of Metoprolol and Propranolol on Asthmatic Airway Obstruction, Br. Med. J. 1: 504 (Feb. 28) 1976.

Sinclair D. J. M. : Comparison of Effects of Propranolol and Metoprolol on Airways Obstruction in Chronic Bronchitis, Brit. Med. J. 1: 168 (Jan. 20) 1979.

Johnsson G. Svedmyr N. Thiringer G. : Effects of Intravenous Propranolol and Metoprolol and Their Interaction with Isoprenaline on Pulmonary Function, Heart Rate and Blood Pressure in Asthmatics, Eur. J. Clin. Pharmacol. 8: 175–180, 1975.

Gladstone G. R. Hordof A. Gersong W. M. : Propranolol Administration During Pregnancy: Effects on the Fetus, J. Pediatr. 86: 962–964 (June) 1975.

Williams L. C. Turney J. H. Parsons V. : Beta-Blocker Withdrawal Syndrome, Lancet 1: 494–495 (Mar. 3) 1979.

Meinertz T. Just H. Kasper W. : Beta-Blocker Withdrawal Syndrome, Lancet 1: 270 (Feb. 3) 1979.

Keyrilainen O. Uusitalo A. : Effects of Metoprolol in Angina Pectoris, Acta Med. Scand. 199: 491–497, 1976.

Comerford M. B. Besterman E. M. M. : An Eighteen Months' Study of the Clinical Response to Metoprolol, A Selective β₁-Receptor Blocking Agent, in Patients with Angina Pectoris, Postgrad. Med. J. 52: 481–486 (Aug.) 1976.

Frick M. H. Luurila U. : Double-Blind Titrated Dose Comparison of Metoprolol and Propranolol in the Treatment of Angina Pectoris, Ann. Clin. Res. 8: 385–392 (Dec.) 1976.

Borer J. S. Comerford M. B. Sowton E. : Assessment of Metoprolol, a Cardioselective Beta-Blocking Agent, During Chronic Therapy in Patients with Angina Pectoris, J. Int. Med. Res. 4: 15–21, 1976.

Malek I. Waagstein F. Hjalmarson A. : Hemodynamic Effects of the Cardioselective β-Blocking Agent Metoprolol in Acute Myocardial Infarction, Acta Med. Scand. 204: 195–201, 1978.

Conolly M. E. Kersting F. Dollery C. T. : The Clinical Pharmacology of Beta-Adrenoceptor-Blocking Drugs, Prog. Cardiovasc. Dis. 19: 203–234 (Nov./Dec.) 1976.

Wasir H. S. Mahapatra R. K. Bhatia M. L. : Metoprolol - A New Cardioselective β-Adrenoceptor Blocking Agent for Treatment of Tachyarrhythmias, Br. Heart J. 39: 834–838, 1977.

Lorimer A. R. Dunn F. G. Jones J. V. Veitch-Lawrie T. D. : Beta-Adrenoceptor Blockade in Hypertension, Am. J. Med. 60: 877–885 (May 31) 1976.

Jaattela A. Pyorala K. : A Controlled Study on the Anti-Hypertensive Effect of a New β-Adrenoceptor-Blocking Drug, Metoprolol, in Combination with Chlorthalidone, Clin. Sci. Mol. Med. 51: 521S–523S (Dec.) 1976.

Bengtsson C. : The Effect of Metoprolol - A New Selective Adrenergic β₁-Receptor Blocking Agent in Mild Hypertension Acta. Med. Scand. 299: 65–70, 1976.

Davidson C. Thadani U. Singleton W. Taylor S. H. : Comparison of Antihypertensive Activity of Beta-Blocking Drugs During Chronic Treatment, Br. Med. J. 2: 7–9 (July 3) 1976.

Bengtsson C. : Comparison Between Metoprolol and Propranolol as Antihypertensive Agents, Acta Med. Scand. 199: 71–74, 1976.

Rosengard S. : Antihypertensive Effect and Tolerability of Metoprolol During Long-Term Treatment: A Multicentre Study, J. Int. Med. Res. 5: 199–206, 1977.

Bergstrand R. H. Vedin J. A. Wilhelmsson C. E. Berglund G. : Comparative Study of Metoprolol and Alpha-Methyldopa in Untreated Essential Hypertension, Eur. J. Cin. Pharmacol. 10: 375–379, 1976.

Pederson O. L. : Comparison of Metoprolol and Hydrochlorothiazide as Antihypertensive Agents, Eur. J. Clin. Pharmacol. 20: 381–385, 1976.

Tuomilehto J. Pakarinen P. : Effects of Metoprolol as Monotherapy and in Combination with Hydralazine in Hypertensive Patients Previously Considered to be Treatment Failures, Curr. Ther. Res. 21: 257–264 (Mar.) 1977.

Filburg M. Z. Oldenzaal R. K. Z. : Antihypertensive Effects of Metoprolol and a Fixed-Ratio Combination of Metoprolol and Hydrochlorothiazide Given Once Daily, Curr. Ther. Res. 24: 26–30 (July) 1978.

Bengtsson C. : Treatment with β-Blockers — Influence of the Dose and Frequency of Administration In 35th Nordic Congress in Internal Medicine, Uleaborg, Finland, p. 29, June 1976.