Abstract
Abstract
French
A case study of an interaction between digoxin and quinidine is presented and its clinical significance is discussed. The serum digoxin concentration increased during quinidine therapy and the patient showed signs of digitalis toxicity. The proposed mechanism, incidence and manifestations of this rise in digoxin serum level are presented. A method of monitoring for this interaction, and its implications for clinical pharmacists, are also given.
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References
1.
Cohen
I.S.
: Adverse Reactions to Quinidine in Hospitalized Patients: Findings Based on Data from the Boston Collaborative Drug Surveillance Program , Prog. Cardiovasc. Dis.
20 : 151 –163 (Sept./Oct.) 1977 .
2.
Miller
R. R.
: Hospital Admissions Due to Adverse Drug Reactions , Arch. Intern. Med.
134 : 219 –223 (Aug.) 1974 .
3.
Doherty
J. E.
Perkings
W. H.
Flanigan
W. J.
: The Distribution and Concentration of Tritiated Digoxin in Human Tissues , Ann. Intern. Med.
66 : 116 –121 (Feb.) 1967 .
4.
Rodensky
R. L.
Wasserman
F.
: Observations on Digitalis Intoxication , Arch. Intern. Med.
108 : 171 –188 (Aug.) 1961 .
5.
Bloom
P. M.
: Relationship of the Excretion of Tritiated Digoxin to Renal Function , Am. J. Med. Sci.
251 : 133 –144 (Feb.) 1961 .
6.
Fowler
R. S.
: Accidental Digitalis Intoxication in Children , J. Pediatr.
64 : 188 –200 (Feb.) 1964 .
7.
Nola
G. T.
: Assessment of the Synergistic Relationship Between Serum Calcium and Digitalis , Am. Heart J.
79 : 499 –507 (Apr.) 1970 .
8.
Seller
D. T.
: Digitalis Toxicity and Hypomagnesemia , Am. Heart J.
79 : 57 –63 (Jan.) 1970 .
9.
Leahey
E. B.
Jr.
: Interaction Between Quinidine and Digoxin , J. Am. Med. Assoc.
240 : 533 –534 (Aug.) 1978 .
10.
Gunnar
E.
: Effect of Quinidine on Plasma Concentrations of Digoxin , Br. Med. J.
1 : 279 –280 (Feb.) 1978 .
11.
McKee
G.
: The Natural History of Congestive Heart Failure: The Framingham Study , N. Engl. J. Med.
285 : 1441 –1445 (Dec.) 1971 .
12.
Wenckelback
K. F.
: Die Unregelmassige Harztatigkeit and ihre Klinische Bedeutung , W. Engelmann , Leipzig , 1914 .
13.
Hartel
G.
: Human Serum and Myocardium Digoxin , Clin. Pharmacol. Ther.
19 : 153 –157 (Feb.) 1976 .