Drug Evaluation Data

Package Inserts for Keflin® and Kefzol®.

AMA Department Of Drugs: AMA Drug Evaluations, 3rd Ed., Publishing Sciences Group, Inc., Littleton, Mass., pp. 712–713, 1977.

Meyers B. R. Leng B. Hirschman S. Z. : Cefamandole: Antimicrobial Activity In Vitro of a New Cephalosporin, Antimicrob. Agents Chemother. 8: 737–741, 1975.

Kaiser G. V. Gorman M. Webber J. A. : Cefamandole—A Review of Chemistry and Microbiology, J. Infect. Dis. (Suppl.) 137: 10–16 (May) 1978.

Wold J. S. Joost R. R. Black H. R. : Hydrolysis of Cefamandole Nafate to Cefamandole in Vivo, J. Infect. Dis. (Suppl.) 137: 17–24 (May) 1978.

Bodey G. P. Weaver S. : In Vitro Studies of Cefamandole, Antimicrob. Agents Chemother. 9: 452–457, 1976.

Brumfitt W. : Cefoxitin and Cephalothin: Antimicrobial Activity, Human Pharmacokinetics and Toxicology, Antimicrob. Agents Chemother. 6: 290–299, 1974.

Eickhoff T. C. Ehret J. M. : In Vitro Comparison of Cefoxitin, Cefamandole, Cephalexin and Cephalothin, Antimimicrob. Agents Chemother. 9: 994–999, 1976.

Finland M. : Susceptibility of Beta-Hemolytic Streptococci to 65 Antibacterial Agents, Antimicrob. Agents Chemother. 9: 11–19, 1976.

Kosmidis J. : Cefoxitin, a New Semi-Synthetic Cephamycin: An In-Vitro and In-Vivo Comparison with Cephalothin, Br. Med. J. 4: 653–655, 1973.

Miller A. K. : Cefoxitin, a Semi-Synthetic Cephamycin Antibiotic: In-Vivo Evaluation, Antimicrob. Agents Chemother. 5: 33–37, 1974.

Neu H. C. : Cefoxitin, a Semisynthetic Cephamycin Antibiotic: Antibacterial Spectrum and Resistance to Hydrolysis by Gram-Negative Beta-Lactamases, Antimicrob. Agents Chemother. 6: 170–176, 1974.

Steward D. Bodey G. P. : Comparative In-Vitro Activity of Cephalosporins, J. Antibiot. 29: 181–186, 1976.

Wallick H. Hendlin D. : Cefoxitin, a Semi-synthetic Cephamycin Antibiotic: Susceptibility Studies, Antimicrob. Agents Chemother. 5: 25–32, 1974.

Washington J. A. : The In-Vitro Spectrum of the Cephalosporins, Mayo Clin. Proc. 51: 237–250, 1976.

Yourassowsky E. Schoutens E. Vanderlinden M. P. : Antibacterial Activity of Eight Cephalosporins Against Haemophilus Influenzae and Streptococcus Pneumoniae, J. Antimicrob. Chemother. 2: 55–59, 1976.

Eykyn S. : Antibacterial Activity of Cefuroxime, A New Cephalosporin Antibiotic, Compared with That of Cephaloridine, Cephalothin, and Cefamandole, Antimicrob. Agents Chemother. 9: 690–695, 1976.

Kammer R. B. : Rapid Detection of Ampicillin-Resistant Haemophilus Influenzae and Their Susceptibility to Sixteen Antibiotics, Antimicrob. Agents Chemother. 8: 91–94, 1975.

Verbist L. : Comparison of the Antibacterial Activity of Nine Cephalosporins Against Enterobacteriaceae and Nonfermentative Gram-Negative Bacilli, Antimicrob. Agents Chemother. 10: 657–663, 1976.

Prince A. Neu H. C. : Beta-Lactamase Activity in Shigella Sonnei, Antimicrob. Agents Chemother. 9: 776–779, 1976.

Finland M. : Susceptibility of Enterobacteria to Penicillins, Cephalosporins, Lincomycins, Erythromycin, and Rifampin, J. Infect. Dis. (Suppl.) 134: S75–S96, 1976.

Neu H. C. : Cefamandole, a Cephalosporin Antibiotic with an Unusually Wide Spectrum of Activity, Antimicrob. Agents Chemother. 6: 177–182, 1974.

Bodey G. P. Weaver S. : In Vitro Studies of Cefamandole, Antimicrob. Agents Chemother. 9: 452–457, 1976.

Meyers B. R. Hirschman S. Z. : Antibacterial Activity of Cefamandole in Vitro, J. Infect. Dis. (Suppl.) 137: 25–31 (May) 1978.

Eickhoff T. C. Ehret J. M. : In Vitro Comparison of Cefoxitin, Cefamandole, Cephalexin and Cephalothin, Antimicrob. Agents Chemother. 9: 994–999, 1976.

Eykyn S. Jenkins C. King A. : Antibacterial Activity of Cefamandole, a New Cephalosporin Antibiotic, Compared with that of Cephaloridine, Cephalothin, and Cephalexin, Antimicrob. Agents Chemother. 3: 657–661, 1973.

Jones R. N. Fuchs P. C. : Comparison of In Vitro Antimicrobial Activity of Cefamandole and Cefazolin with Cephalothin Against Over 8,000 Clinical Bacterial Isolates, Antimicrob. Agents Chemother. 9: 1066–1069, 1976.

Ernst E. C. Berger S. Barza M. : Activity of Cefamandole and Other Cephalosporins Against Aerobic and Anaerobic Bacteria, Antimicrob. Agents Chemother. 9: 852–855, 1976.

Griffith R. S. Brier G. L. Wolny J. D. : Synergistic Action of Erythromycin and Cefamandole Against Bacteroides fragilis Subsp. fragilis, Antimicrob. Agents Chemother. 11: 813–816, 1977.

Fu K. P. Neu H. C. : A Comparative Study of the Activity of Cefamandole and Other Cephalosporins and Analysis of the Beta-Lactamase Stability and Synergy of Cefamandole with Aminoglycosides, J. Infect. Dis. (Suppl.) 137: 38–48 (May) 1978.

Findell C. M. Sherris J. C. : Susceptibility of Enterobacter to Cefamandole: Evidence for a High Mutation Rate of Resistance, Antimicrob. Agents Chemother. 9: 970–974, 1976.

Adams H. G. Stilwell G. A. Turck M. : In Vitro Evaluation of Cefoxitin and Cefamandole, Antimicrob. Agents Chemother. 9: 1019–1024, 1976.

Strausbaugh L. J. Mikhail I. A. Edman D. C. : Comparative In Vitro Activity of Five Cephalosporin Antibiotics Against Salmonellae, Antimicrob. Agents Chemother. 13: 134–136 (Jan.) 1978.

Lewis R. P. Meyer R. D. Kraus L. L. : Antibacterial Activity of Selected Beta-Lactam and Aminoglycoside Antibiotics Against Cephalosporin-Resistant Enterobacteriaceae, Antimicrob. Agents Chemother. 9: 780–786, 1976.

Jorgensen J. H. Alexander G. A. : Comparative Activities of Selected Beta-Lactam Antibiotics Against Haemophilus Influenzae, Antimicrob. Agents Chemother. 13: 342–343 (Feb.) 1978.

Barros F. Korzeniowski O. M. Sande M. A. : In Vitro Antibiotic Susceptibility of Salmonellae, Antimicrob. Agents Chemother. 11: 1071–1073, 1977.

Sykes R. B. Matthew M. : The Beta-Lactamases of Gram Negative Bacteria and Their Role in Resistance to Beta-Lactam Antibiotics, J. Antimicrob. Chemother. 2: 115–157, 1976.

Fu K. P. Neu H. C. : A Comparative Study of the Activity of Cefamandole and Other Cephalosporins and Analysis of the Beta-Lactamase Stability and Synergy of Cefamandole with Aminoglycosides, J. Infect. Dis. (Suppl.) 137: 38 (May) 1978.

Meyers B. R. Shear K. Wormser G. : Cefamandole Therapy in Seriously Ill Hospitalized Patients, Proceedings of the 10th International Congress of Chemotherapy, American Society for Microbiology, Washington, D. C., 1978.

Parry M. F. Garvey G. J. Goldberger M. J. : Treatment of Serious Infections with Cefamandole, Proceedings of the 10th International Congress of Chemotherapy, American Society for Microbiology, Washington, D.C., 1978.

Perkins R. L. Fass R. J. Warner J. F. : Cefamandole Nafate Therapy of Respiratory Tract, Skin, and Soft Tissue Infections in 74 Patients, J. Infect. Dis. (Suppl. 137: 110–117 (May) 1978.

Stone H. H. : Cefamandole in the Treatment of Surgical Infections, Proceedings of the 10th International Congress of Chemotherapy, American Society for Microbiology, Washington, D.C., 1978.

Perlino C. A. Plaut M. E. : Cefamandole Treatment of Bacterial Pneumonia, Curr. Ther. Res. 22: 807–813 (Dec.) 1977.

Plaut M. E. Perlino C. A. : Cefamandole vs. Procaine Penicillin for Treatment of Pneumonia Due to Streptococcus pneumoniae: A Random Trial, J. Infect. Dis. (Suppl.) 137: 133–138 (May) 1978.

Levine L. R. McCain E. : Cefamandole in the Treatment of Infections Due to Enterobacter and Indole-Positive Proteus, J. Infect. Dis. (Suppl.) 137: 125–132 (May) 1978.

Rodriguez W. J. Ross S. Khan W. N. : Clinical and Laboratory Evaluation of Cefamandole in Infants and Children, J. Infect. Dis. (Suppl.) 137: 150–154 (May) 1978.

Azimi P. H. : Clinical and Laboratory Investigation of Cefamandole Therapy of Infections in Infants and Children, J. Infect. Dis. (Suppl.) 137: 155–160 (May) 1978.

Khurana C. M. Levin S. Mehta S. : Clinical Evaluation of Cephamandole in Neonatal Sepsis, 17th Interscience Conference on Antimicrobial Agents and Chemotherapy, (Abstract 226), Oct. 12–14. 1977.

Cox C. E. : Controlled Trial of Cefamandole and Cefazolin in the Treatment of Urinary Tract Infections, Proceedings of the 10th International Congress of Chemotherapy, American Society for Microbiology, Washington, D.C., 1978.

Short H. D. Gentry L. O. Sessoms S. : Cefamandole Nafate Therapy in the Treatment of Acute Urinary Tract Infections, J. Antimicrob. Chemother. 2: 345–350. 1976.

Levine L. R. McCain E. : Clinical Experience with Cefamandole for Treatment of Serious Bone and Joint Infections, J. Infect. Dis. (Suppl.) 137: 119–124 (May) 1978.

Minor M. R. Sande M. A. Dilworth J. A. : Cefamandole Treatment of Pulmonary Infection Caused by Gram-Negative Rods, J. Antimicrob. Chemother. 2: 49–53, 1976.

Russell D. G. Levine L. R. McCain E. : Cefamandole in the Treatment of Anaerobic Infections (Abstract), 17th Interscience Conference on Antimicrobial Agents and Chemotherapy, American Society for Microbiology, 1977.

Korzeniowski O. M. Carvalho E. M. Jr. Rocha H. : Evaluation of Cefamandole Therapy of Patients with Bacterial Meningitis, J. Infect. Dis. (Suppl.) 137: 169–179 (May) 1978.

Steinberg E. A. Overturf G. D. Wilkins J. : Failure of Cefamandole in Treatment of Meningitis Due to Haemophilus influenzae Type b, J. Infect. Dis. (Suppl.) 137: 180–186 (May) 1978.

Bodey G. P. Ketchel S. Rodriguez V. : Carbenicillin plus Cefamandole in the Treatment of Infections in Patients with Cancer, J. Infect. Dis. (Suppl.) 137: 139–143 (May) 1978.

Gentry L. O. : Efficacy and Safety of Cefamandole plus either Gentamicin or Tobramycin in Therapy of Severe Gram-Negative Bacterial Infections, J. Infect. Dis. (Suppl.) 137: 144–149 (May) 1978.

Fong I. W. Ralph E. D. Engelking E. R. : Clinical Pharmacology of Cefamandole as Compared with Cephalothin, Antimicrob. Agents Chemother. 9: 65–69, 1976.

Meyers B. R. Ribner B. Yancovitz S. : Pharmacological Studies with Cefamandole in Human Volunteers, Antimicrob. Agents Chemother. 9: 140–144, 1976.

Griffith R. S. : Pharmacokinetics of Cefamandole, Antimicrob. Agents Chemother. 10: 814–823, 1976.

Barza M. Melethil S. Berger S. : Comparative Pharmacokinetics of Cefamandole, Cephapirin, and Cephalothin in Healthy Subjects and Effect of Repeated Dosing, Antimicrob. Agents Chemother. 10: 421–425, 1976.

Neu H. C. : Comparison of the Pharmacokinetics of Cefamandole and Other Cephalosporin Compounds, J. Infect. Dis. (Suppl.) 137: 80–87 (May) 1978.

Griffith R. S. Black H. R. Brier G. L. : Effect of Probenecid on the Blood Levels and Urinary Excretion of Cefamandole, Antimicrob. Agents Chemother. 11: 809–812, 1977.

Kraft D. Baruch B. Koeppe P. : Cefamandole Pharmacokinetics in Patients with Chronic Renal Failure: Clinical Evaluation, Proceedings of the 10th International Congress of Chemotherapy, American Society for Microbiology, Washington, D.C., 1978.

Bodey G. P. Grose W. E. Ketchel S. J. : Evaluation of Cefamandole, Proceedings of the 10th International Congress of Chemotherapy, American Society for Microbiology, Washington, D.C., 1978.

Naber K. G. Zinati A. H. : Pharmacokinetic Studies and Therapeutic Evaluation of Cefamandole in Urology, Proceedings of the 10th International Congress of Chemotherapy, American Society for Microbiology, Washington, D.C., 1978.

Regamey C. Volanthen M. : Pharmacokinetics of Cefamandole and Cephalothin After Intravenous Administration in Healthy Adult Volunteers and In Vitro Antibacterial Spectrum, Proceedings of the 10th International Congress of Chemotherapy, American Society for Microbiology, Washington, D.C., 1978.

Ahern M. J. Finkelstein F. O. Andriole V. T. : Pharmacokinetics of Cefamandole in Patients Undergoing Hemodialysis and Peritoneal Dialysis, Antimicrob. Agents Chemother. 10: 457–461, 1976.

Appel G. B. Neu H. C. Parry M. F. : Pharmacokinetics of Cefamandole in the Presence of Renal Failure and in Patients Undergoing Hemodialysis, Antimicrob. Agents Chemother. 10: 623–625, 1976.

Griffith R. S. Black H. R. Brier G. L. : Cefamandole: In Vitro and Clinical Pharmacokinetics, Antimicrob. Agents Chemother. 10: 814–823, 1976.

Ratzan K. R. Baker H. B. Lauredo I. : Comparison of the Biliary Tract Excretion of Cefamandole, Cefazolin, and Cephalothin, Proceedings of the 10th International Congress of Chemotherapy, American Society for Microbiology, Washington, D.C., 1978.

Archer G. L. Polk R. E. Duma R. J. : Comparison of Cephalothin and Cefamandole Prophylaxis During Insertion of Prosthetic Heart Valves, Antimicrob. Agents Chemother. 13: 924–929 (June) 1978.

Steinberg E. A. Overturf G. D. Baraff L. J. : Penetration of Cefamandole into Spinal Fluid, Antimicrob. Agents Chemother. 11: 933–935, 1977.

Quinn E. L. Madhavan T. Wixson R. : Cefamandole: Observations on Its Spectrum, Concentration in Bone and Bile, Excretion in Renal Failure, and Clinical Efficacy, Proceedings of the 10th International Congress of Chemotherapy, American Society for Microbiology, Washington. D.C., 1978.

Axelrod J. L. Kochman R. S. : Cefamandole Concentrations in Human Aqueous Humor, Proceedings of the 10th International Congress of Chemotherapy, American Society for Microbiology, Washington. D.C., 1978.

Tan J. S. Salstrom S. J. : Levels of Carbenicillin, Ticarcillin, Cephalothin, Cefazolin, Cefamandole, Gentamicin, Tobramycin, and Amikacin in Human Serum and Interstitial Fluid, Antimicrob. Agents Chemother. 11: 698, 1977.

Personal communication with Eli Lilly and Company, July, 1978.

Liu C. Hinthorn D. R. Hodges G. R. : Clinical Evaluations of the Efficacy and Safety of Cefamandole Nafate, Proceedings of the 10th International Congress of Chemotherapy, American Society for Microbiology, Washington, DC, 1978.

Ekwall E. Holmgren E. B. Lundbergh P. : Cefamandole Nafate: An Evaluation of Clinical Effect, Absorption and Incidence of Side Reactions in 58 Patients, Proceedings of the 10th International Congress of Chemotherapy, American Society for Microbiology, Washington, D.C., 1978.

Berger S. Ernst E. C. Barza M. : Comparative Incidence of Phlebitis Due to Buffered Cephalothin, Cephapirin, and Cefamandole, Antimicrob. Agents Chemother. 9: 575–579, 1976.