Drug Evaluation Data

Product Information, Abbott Laboratories, North Chicago, Illinois.

Mattson R. H. : Valproic Acid in Epilepsy: Clinical and Pharmacological Effects, Ann. Neurol. 3: 20–25, 1978.

Godin Y. : Effects of Di-N-Propylacetate, An Anticonvulsant Compound, on GABA Metabolism, J. Neurochem. 16: 869–873, 1969.

Staler S. : Effect of Sodium Di-N-Propylacetate on Audiogenic Seizures and Brain Gamma-Aminobutyric Acid Level, Biochem. Pharmacol. 22: 1701–1703, 1973.

Sawaya M. C. B. : Effects of Anticonvulsant Drugs on the Cerebral Enzymes Metabolizing GABA, Epilepsia 16: 649–655, 1975.

Horton R. W. : Monoamine and GABA Metabolism and the Anticonvulsant Action of Di-N-Propylacetate and Ethanolamine-D-Sulphate, Eur. J. Pharmacol. 41: 387–397, 1977.

Harvey P. K. P. : Some Aspects of the Neurochemistry of Epilim®, In Legg (Ed.): Clinical and Pharmacological Aspects of Sodium Valproate (Epilim®) in the Treatment of Epilepsy, MCS Consultants, Tunbridge Wells, pp. 130–134, 1976.

Swinyard E. A. : The Pharmacology of Dipropylacetic Acid Sodium with Special Emphasis on its Effect on the Central Nervous System, University of Utah College of Pharmacy, Salt Lake City, Utah, pp. 1–25, 1964.

Pinder R. M. : Sodium Valproate: A Review of its Pharmacological Properties and Therapeutic Efficacy in Epilepsy, Drugs 13: 81–123, 1977.

Simon D. Penry J. K. : Sodium Di-N-Propylacetate (DPA) in the Treatment of Epilepsy. A Review, Epilepsia 16: 549–573, 1975.

Whittle B. A. : Pre-clinical Teratological Studies on Sodium Valproate (Epilim®) and other Anticonvulsants, In Legg (Ed.): Clinical and Pharmacological Aspects of Sodium Valproate (Epilim®) in the Treatment of Epilepsy, MCS Consultants, Tunbridge Wells, pp. 105–110, 1976.

Loiseau P. : Concentration of Dipropylacetate in Plasma, Epilepsia 16: 609–615, 1975.

Klotz V. : Pharmacokinetics and Bioavailability of Sodium Valproate, Clin. Pharmacol. Ther. 21: 736–743, 1977.

Meindardi H. : Absorption and Distribution of Anti-epileptic Drugs, Epilepsia 16: 353–365, 1975.

Wulff K. : Clinical Pharmacological Aspects of Valproate Sodium, Epilepsia 18: 149–157, 1977.

Richens A. : Pharmacokinetics and Efficacy of Epilim® in Patients Receiving Long-Term Therapy with other Anti-epileptic Drugs, In Legg (Ed.): Clinical and Pharmacological Aspects of Sodium Valproate (Epilim®) in the Treatment of Epilepsy, MCS Consultants, Tunbridge Wells, pp. 78–88, 1976.

Meindardi H. : Sodium Di-N-Propylacetate: Estimation of Effective Serum Levels, Pharm. Weekbl. 109: 45–47, 1974.

Schobben F. : Pharmacokinetics of Di-N-Propylacetate in Epileptic Patients, Eur. J. Clin. Pharmacol. 8: 97–105, 1975.

Meijer J. W. A. : Pharmacokinetic Studies on Sodium Valproate, In Legg (Ed.): Clinical and Pharmacological Aspects of Sodium Valproate (Epilim®) in Epilepsy, MCS consultants, Tunbridge Wells, pp. 70–74, 1976.

Schobben F. : Determination of Sodium Di-n-Propylacetate in Plasma by Gas-liquid Chromatography, Pharm. Weekbl. 109: 30–33, 1974.

Lockard J. S. : Diurnal Variation of Valproic Acid Plasma Levels and Day-Night Reversal in Monkey, Epilepsia 18: 183–189, 1977.

Ferrandes B. : Methode Rapide D'analyse Quantitative Dipropylacetate de Sodium dans le Serum ou le Plasma, Ann. Pharm. Fr. 31: 279–282, 1973.

Kukino K. : Gamma-Oxidation of Sodium Dipropylacetate, an Anticonvulsant Drug, in Rats, Res. Biochem. Met. Natl. Pharmacol. 2: 1382, 1974.

Ferrandes B. : Metabolism of Valproate Sodium in Rabbit, Rat, Dog, and Man, Epilepsia 18: 169–181, 1977.

Adams J. J. : Sodium Valproate in the Treatment of Intractable Seizure Disorders: A Clinical Electroencephalographic Study, Neurology 28: 152–157, 1978.

Loscher W. : Rapid Determination of Valproate Sodium in Serum by Gas-Liquid Chromatography, Epilepsia 18: 255–266, 1977.

Richens A. Ahmad S. : Controlled Trial of Sodium Valproate in Severe Epilepsy, Br. Med. J. 4: 255–256, 1975.

Meindardi H. : Clinical Trials of Anti-Epileptic Drugs, Psychiatria Neurologia Neurochirurgia 74: 141, 1971.

Suzuck M. : A Double-Blind Comparative Trial of Sodium Dipropylacetate and Ethosuximide in Epilepsy in Children With Special Emphasis on Pure Petit Mal Seizure, Med. Progress 82: 470–488, 1972.

Gram L. : Valproate Sodium: A Controlled Clinical Trial Including Monitoring of Drug Levels, Epilepsia 18: 141–148, 1977.

Adams D. J. : Sodium Valproate in the Treatment of Intractable Seizure Disorders: A Clinical and Electroencephalographic Study, Neurology 28: 152–157, 1978.

Lance J. W. Anthony M. : Sodium Valproate and Clonazepam in the Treatment of Intractable Epilepsy, Arch. Neurol. 34: 14–17, 1977.

Lance J. W. Anthony M. : The Anticonvulsant Action of Sodium Valproate (Epilim®) in 100 Patients with Forms of Epilepsy, Med. J. Aust. 11: 911–915, 1977.

Cavazzuti G. B. : Prevention of Febrile Convulsion with Dipropylacetate (Depakine®), Epilepsia 16: 647–648, 1975.

Jeavons P. M. Clark J. E. : Sodium Valproate in the Treatment of Epilepsy, Br. Med. J. 2: 584–586, 1974.

Richardson S. G. M. : Sodium Valproate and Platelet Function, Br. Med. J. 1: 221–222, 1976.

VonVoss H. : Sodium Valproate and Platelet Function, Br. Med. J. 2: 179, 1976.

Winfield D. A. : Sodium Valproate and Thrombocytopenia, Br. Med. J. 4: 981, 1976.

Sodium Valproate: A New Anticonvulsant, Medical Letter 19: 93–94, 1977.

Sutor A. H. Jesdinsky-Buscher C. : Gerinnungsveranderungen Durch Dipropyllessigsaure (Ergenyl®), Med. Welt. 25: 447–449, 1974.

Joubert P. H. : Epilepsy and IgA Deficiency — The Effect of Sodium Valproate, S. African Med. J. 52: 642–644, 1977.

Vakil S. D. : The Effect of Sodium Valproate (Epilim®) on Phenytoin and Phenobarbital Blood Levels, In Legg (Ed.): Clinical and Pharmacological Aspects of Sodium Valproate (Epilim®) in the Treatment of Epilepsy, MCS Consultants, Tunbridge Wells, pp. 75–77, 1976.

Jeavons P. M. : Treatment of Generalized Epilepsies with Sodium Valproate (Epilim®), Developmental Medicine and Child Neurology 19: 9–25, 1977.

Vajda F. : Studies on Sodium Valproate — A New Anticonvulsant, In Legg (Ed.): Clinical and Pharmacological Aspects of Sodium Valproate (Epilim®) in the Treatment of Epilepsy, MCS Consultants, Tunbridge Wells pp. 92–100, 1976.

Mattson R. H. : Valproic Acid in Epilepsy: Clinical and Pharmacological Effects, Ann. Neurol. 3: 20–25, 1978.

Bard A. : Valproate May Lower Serum-Phenytoin, Lancet 4: 1297, 1976.

Patsalos P. N. Lascelles P.T. : Valproate May Lower Serum-Phenytoin, Lancet 1: 50–51, 1977.

Palsalos P. N. Lascelles P. T. : Effect of Sodium Valproate on Plasma Protein Binding of Diphenylhydantoin, J. Neurol. Neurosurg. Psychiatry 40: 570–574, 1977.