It is seldom recognized that heat stroke can be precipitated by drug therapy. Drugs that alter normal body thermoregulation and the mechanisms of drug action on thermoregulation are discussed, together with normal body thermoregulation and heat stroke. Complications arising from heat stroke and their treatment are presented.
ReimerD.MohanJ.SubramoneyN.: Heat Dys-control Syndrome in Patients Receiving Antipsychotic, Antidepressant and Anti-Parkinson Drug Therapy, J. Florida Med. Assoc.61: 573–574 (July) 1974.
3.
WiseT. N.: Heat Stroke in Three Chronic Schizophrenics: Case Reports and Clinical Considerations, Compr. Psychiatry14: 263–267 (May/June) 1973.
4.
GreenblattD. J.GreenblattG. R.: Chlorpromazine and Hyperpyrexia: A Reminder That This Drug Affects the Mechanisms Which Regulate Body Temperature, Clin. Pediatr.12: 504–505 (Aug.) 1973.
5.
WestlakeR. J.RastegarA.: Hyperpyrexia from Drug Combinations, J. Am. Med. Assoc.225: 1250 (Sept. 3) 1973.
6.
LitmanR. E.: Heat Sensitivity Due to Autonomic Drugs, J. Am. Med. Assoc.149: 635–636 (June 14) 1952.
7.
ZelmanS.GuillanR.: Heat Stroke in Pheno-thiazine-Treated Patient: A Report of Three Fatalities, Am. J. Psychiatry126: 129–132 (June) 1970.
8.
EllisF.: Heat Wave Deaths and Drugs Affecting Temperature Regulation (Letter), Br. Med. J.2: 474 (Aug. 21) 1976.
9.
HoaglandR. J.BishopR. H.: A Physiologic Treatment of Heat Stroke, Am. J. Med. Sci.241: 415–422, 1961.
10.
ClowesG. H.O'DonnellT. F.: Heat Stroke, N. Engl. J. Med.291: 564–567 (Sept. 12) 1974.
WheelerM.: Heat Stroke in the Elderly, Med. Clin. North Am.60: 1289–1296, 1976.
14.
ForlichE. D.: Pathophysiology-Altered Regulatory Mechanisms in Disease, J. B. Lippincott Company, Philadelphia, Pa., p. 702, 1976.
15.
PenovichP.: Drug-induced Hyperpyrexia and Heat Stroke, Drug Therapy6: 101–102 (Aug.) 1976.
16.
LomaxP.KirkpatrickW. E.: Interactions of Chlorpromazine with Monoamines in the Hypothalamic Thermoregulatory Centers, Adv. Biochem. Psychopharm.8: 719–729, 1974.
17.
KennedyM. S.BurksT. F.: Dopamine Receptors in the Central Thermoregulatory Mechanism of the Cat, Neuropharmacology13: 119, 1974.
18.
YehudaS.WurtmanR. J.: Paradoxical Effects of Diamphetamine on Behavioral Thermoregulation: Possible Mediation by Brain Dopamine, J. Pharm. Exp. Ther.190: 118, 1974.
KnochelJ. P.BeiselW. R.HerndonE. G.: The Renal, Cardiovascular, Hematologic and Serum Electrolyte Abnormalities of Heat Stroke, Am. J. Med.30: 299–310, 1961.
27.
KewM.BershonI.SeftelH.: Liver Damage in Heat Stroke, Am. J. Med.49: 192–202, 1970.
28.
SamquistF.: Heat Stroke (Letter)N. Engl. J. Med.292: 51, 1975.
29.
RomesJ. A.: Heat Stroke, Mil. Med.131: 669–677, 1966.
30.
O'DonnellT. F.ClowesG. H.: The Circulatory Abnormalities of Heat Stroke, N. Engl. J. Med.287: 734–737 (Oct. 12) 1972.