Over the past few years an association between oral contraceptive use and liver tumors has been suggested, and this is now being studied on an epidemiological basis. Large scale retrospective studies to date support a relationship between oral contraceptive use and benign liver tumors. These tumors carry a significant risk of spontaneous rupture. The possible relationship with malignant liver tumors is also discussed. Clinical aspects of these tumors are presented, as well as suspected oncogenic mechanisms.
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