Generalized convulsions developed in a uremic patient who had received massive doses of cefazolin which resulted in a measured serum level of greater than 512 mcg/ml of drug after dialysis. Pathophysiologic mechanisms which could have contributed to the symptoms are discussed. Physicians prescribing cefazolin and other cephalosporins need to be aware of this potential complication of therapy and adjust doses accordingly in renal failure.
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LevisonM. E.LevisonS. P.RiesK.: Pharmacology of Cefazolin in Patients with Normal and Abnormal Renal Function, J. Infect. Dis.128 (suppl.): S354–S357 (Oct.) 1973.
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CraigW. A.WellingP. G.KuninC. M.: Pharmacology of Cefazolin and Other Cephalosporins in Patients with Renal Insufficiency, J. Infect. Dis.128 (suppl.): S347–353 (Oct.) 1973.
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McCloskeyR. V.ForlandM. F.SweeneyM. J.: Hemodialysis of Cefazolin, J. Infect. Dis.128 (suppl.): S358–360 (Oct.) 1973.
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23.
Personal Communication: Wayne Turner, R.Ph., Adverse Reactions Division. FDA, Washington, D.C.
