The History of Pharmacokinetics

Michaelis L. Menten M. L. : Die Kinetik der Invertinwirking, Biochem. Z. 49: 333–369, 1913.

Widmark E. Tandberg J. : Uber die Bedingungen für die Akkumulation Indifferenter Narkoliken Theoretische Bereckerunger, Biochem. Z. 147: 358–369, 1924.

Dominguez R. : Studies of Renal Excretion of Creatinine II. Volume of Distribution, Proc. Soc. Exp. Biol. Med. 31: 1146, 1150, 1934.

Dominguez R. Corcoran A. C. Page I. H. : Mannitol: Kinetics of Distribution, Excretion and Utilization in Human Beings, J. Lab. Clin. Med. 32: 1192–1202, 1947.

Dominguez R. Goldblatt H. Pomerene E. : Kinetics of the Excretion and Utilization of Xylose, Am. J. Physiol. 119: 429–438, 1937.

Dominguez R. Goldblatt H. Pomerene E. : Kinetics of the Elimination of Substances Injected Intravenously (Experiments with Creatinine), Am. J. Physiol. 114: 240–254, 1935.

Dominguez R. Pomerene E. : Recovery of Creatinine After Ingestion and After Intravenous Injection in Man, Proc. Soc. Exp. Biol. Med. 58: 26–28, 1945.

Dominguez R. Pomerene E. : Studies of Renal Excretion of Creatinine I. On the Functional Relation between the Rate of Output and the Concentration in the Plasma, J. Biol. Chem. 104: 449–471, 1934.

Dominguez R. Pomerene E. : Calculation of Rate of Absorption of Exogenous Creatinine, Proc. Soc. Exp. Biol. Med. 60: 173–181, 1945.

Dominguez R. Pomerene E. : Kinetics of the Disappearance of Galactose from the Plasma after a Rapid Intravenous Injection, Am. J. Physiol. 141: 368–381, 1944.

Dominguez R. : Kinetics of Elimination, Absorption and Volume of Distribution in the Organism, Medical Physics II, Yearbook Publishers, Inc., Chicago, Illinois, pp. 476–489, 1950.

Teorell T. : Kinetics of Distribution of Substances Administered to the Body I. The Extravascular Modes of Administration, Arch. Int. Pharmacodyn. 57: 205–225, 1937.

Teorell T. : Kinetics of Distribution of Substances Administered to the Body. II. The Intravascular Modes of Administration, Arch. Int. Pharmacodyn. 57: 226–240, 1937.

Boxer G. E. Jelinek V. C. : Streptomycin in the Blood: Chemical Determinations after Single and Repeated Intramuscular Injections, J. Pharmacol. Exp. Ther. 92: 226–235, 1948.

Gaudino M. : Kinetics of. Distribution of Inulin between Two Body Water Compartments, Proc. Soc. Exp. Biol. Med. 70: 672–674, 1949.

Solomon A. K. : Equations for Tracer Experiments, J. Clin. Invest. 28: 1297–1307, 1949.

De Jong S. E. Wijans M. : The Influence of Divided Doses of Drugs on the Duration of Effect and Integral of Effect, Acta Physiol. Pharmacol. Need. 1: 237–258, 1950.

Van Gemert A. G. M. Duyff J. W. : Optimal Dosage of Drugs, Acta Physiol. Pharmacol. Neerl. 1: 256–278, 1950.

Dost F. H. : Der Blütspiegelkinetik der Konzentration-sablaüfe in der Krieslaufflüssigkeit, G. Thiem, Leipzig, 1953.

Butler T. C. Mahaffe C. Waddell W. J. : Phenobarbital: Studies of Elimination, Accumulation, Tolerance and Dosage Schedules, J. Pharmacol. Exp. Ther. 111: 425–435, 1954.

Butler T. C. : Termination of Drug Action by Elimination of Unchanged Drug, Fed. Proc. 17: 1158–1162, 1958.

Berman M. Schoenfeld R. : Invariants in Experimental Data in Linear Kinetics and the Formation of Models, J. Appl. Physiol. 27: 1361–1370, 1956.

Swintosky J. V. Robinson M. J. Foltz E. L. Free S. M. : Sulfaethyl-thiadiazole I. Interpretation of Human Blood Concentrations Following Oral Doses, J. Am. Pharm. Assoc. Sci. Ed. 46: 339–403, 1957. II. Distribution and Disappearance from Tissues Following Intravenous Doses, ibid, 403–411, 1957.

Riegelman S. Cromwell W.J. : Kinetics of Rectal Absorption I. Preliminary Investigation into the Absorption Process, J. Am. Pharm. Assoc. Sci. Ed. 47: 115–122, 1958. II. The Absorption of Anions, ibid, 123–127, 1958. III. The Absorption of Undissociated Molecules, ibid, 127–133, 1958.

Nelson E. : Influence of Dissolution Rate and Surface Area on Tetracycline Absorption, J. Am. Pharm. Assoc. Sci. Ed. 48: 96–103, 1959.

Nelson E. Schaldemose I. : Urinary Excretion Kinetics for Evaluation of Drug Absorption. I. Solution Rate Limited and Nonsolution Rate of Sulfaethylthiadiazole, J. Am. Pharm. Assoc. Sci. Ed. 48: 489–495, 1959.

Stephenson J. L. : Theory of Transport in Linear Biological Systems I. Fundamental Integral Equations, Bull. Math. Biophys. 22: 1–17, 1960.

Jenne J. W. MacDonald F. M. Mendoza E. : A Study of the Factors Influencing the Fall-Off of Intravenous Isoniazid and Para-aminosalicylic Acid, Conference on the Chemotherapy of Tuberculosis 19: 34–43, 1960.

Wagner J. G. Carpenter O. S. Collins E. J. : Sustained Action Oral Medication I. A Quantitative Study of Prednisolone in Man, in the Dog and in Vitro, J. Pharmacol. Exp. Ther. 129: 101–107, 1960.

Garrett E. R. Thomas R. C. Wallach D. P. Alway C. D. : Kinetics and Mechanisms in Vitro with Application of the Analog Computer, J. Pharmacol. Exp. Ther. 130: 106–118, 1960.

Jacquez J. A. Bellman R. Kalaba R. : Some Mathematical Aspects of Chemotherapy II. The Distribution of a Drug in the Body, Bull. Math. Biophys. 22: 309–322, 1960.

Krüger-Thiemer E. : Dosage Schedules and Pharmacokinetics in Chemotherapy, J. Am. Pharm. Assoc. Sci. Ed. 49: 311–313, 1960.

Krüger-Thiemer E. : Functional Relation between Pharmacokinetic Properties and Dosage Schedule of Chemo-therapeutic Agents, Klin. Wochschr. 38: 514–520, 1960.

Krüger-Thiemer E. Bünger P. : Cumulation and Toxicity as Result of Wrong Dosage Schedule of Sulfonamides, Arzneimittel-Forsch. 11: 867–874, 1961.

Wagner J. G. : Biopharmaceutics: Absorption Aspects, J. Pharm. Sci. 50: 359–387, 1961.

Shore M. L. : Biological Applications of Kinetic Analysis of a Two-Compartment Open System, J. Appl. Physiol. 16: 771–782, 1961.

Nogami H. Matsuzawa T. : Studies of Absorption and Excretion of Drugs. I. Kinetics of Penetration of Acidic Drug, Salicylic Acid, through the Intestinal Barrier in Vitro, Chem. Pharm. Bull. (Tokyo) 9: 532–540, 1961.

Levy G. Gumtow R. H. Rutowski J. M. : The Effect of Dosage Form Upon the Gastrointestinal Absorption Rate of Salicylates, Can. Med. Assoc. J. 85: 414–419, 1961.