Drug Evaluation Data

Mendeloff A. I. : What Has Been Happening to Duodenal Ulcer?, Gastroenterology 67: 1020 (Dec.) 1974.

Black J. W. : Definition and Antagonism of Histamine H₂-Receptors, Nature 236: 385 (Apr. 21) 1972.

Wyllie J. H. : Effects in Man of Histamine H₂-Receptor Blockade by Burimamide, Lancet 2: 1117 (Nov. 25) 1972.

Mainardi M. : Metiamide, an H₂-Receptor Blocker, as Inhibitor of Basal and Meal-Stimulated Gastric Acid Secretion in Patients with Duodenal Ulcer, N. Engl. J. Med. 291: 373 (Aug. 22) 1974.

Spence R. : Neutropenia Associated with Metiamide, Lancet 1: 392 (Feb. 15) 1975.

Editorial: H₂-Receptor Antagonists in the Treatment of Peptic Ulcer, Ann. Intern. Med. 84: 212–214 (Feb.) 1976.

Ganellin C. E. Durant G. J. Emmett J. C. : Some Chemical Aspects of Histamine H₂-Receptor Antagonists, Fed. Proc. 35: 1924–1930 (June) 1976.

Durant G. J. Emmett J. C. Ganellin C. R. : Chemical Origin and Properties of Histamine H₂-Receptor Antagonists, Proceedings of the Second International Symposium on Histamine H₂-Receptor Antagonists, pp. 1–11 (Oct. 26–27) 1976.

Henn R. : Inhibition of Gastric Acid Secretion by Cimetidine in Patients with Duodenal Ulcer, N. Engl. J. Med. 293: 371 (Aug. 21) 1975.

Pounder R. E. : Healing of Gastric Ulcer During Treatment with Cimetidine, Lancet 1: 337 (Feb. 14) 1976.

Longstreth G. F. : Cimetidine Suppression of Nocturnal Gastric Secretion in Active Duodenal Ulcer, N. Engl. J. Med. 294: 801 (Apr. 8) 1976.

Hollander D. : Inhibition of Nocturnal Acid Secretion in Duodenal Ulcer Patients by an H₂ Histamine Antagonist-Cimetidine, Dig. Dis. 21: 361 (May) 1976.

Cano R. : Cimetidine Inhibits Caffeine-Stimulated Gastric Acid Secretion in Man, Gastroenterology 70: 1055 (June) 1976.

Gray G. R. : Oral Cimetidine in Severe Duodenal Ulceration, Lancet 1: 4 (Jan.) 1977.

Pounder R. E. : The Effects of Oral Cimetidine on Food-Stimulated Gastric Acid Secretion and 24-hour Intragastric Acidity, Proceedings of The Second International Symposium on Histamine H₂-Receptor Antagonists, pp. 189–206 (Oct. 26–27) 1976.

Semb L. S. : A Double-Blind Multicenter Comparative Study of Cimetidine and Placebo in Short-Term Treatment of Active Duodenal Ulceration, Proceedings of The Second International Symposium on Histamine H₂-Receptor Antagonists, pp. 248–253 (Oct. 26–27) 1976.

Blackwood W. S. Northfield T. C. : Nocturnal Gastric Acid Secretion: Effect of Cimetidine and Interactions with Anticholinergics, Proceedings of The Second International Symposium on Histamine H₂-Receptor Antagonists, pp. 124–134 (Oct. 26–27) 1976.

McCluskie K. D. : Cimetidine in the Treatment of Esophagitis, Proceedings of The Second International Symposium on Histamine H₂-Receptor Antagonists, pp. 295–305 (Oct. 26–27) 1976.

Stage J. G. : Treatment of Zollinger-Ellison Patients with Cimetidine, Proceedings of The Second International Symposium on Histamine H₂-Receptor Antagonists, pp. 306–310 (Oct. 26–27) 1976.

Bonfils S. : Biological Studies During Long-Term Cimetidine Administration in Zollinger-Ellison Syndrome, Proceedings of The Second International Symposium on Histamine H₂-Receptor Antagonists, pp. 311–321 (Oct. 26–27) 1976.

MacDougall B. R. D. : Histamine H₂-Receptor Antagonists in the Prophylaxis and Control of Acute Gastrointestinal Hemorrhage with Cimetidine, Proceedings of The Second International Symposium on Histamine H₂-Receptor Antagonists, pp. 329–336 (Oct. 26–27) 1976.

Dykes P. W. : Treatment of Upper Gastrointestinal Hemorrhage with Cimetidine, Proceedings of The Second International Symposium on Histamine H₂-Receptor Antagonists, pp. 337–344 (Oct. 26–27) 1976.

Sewing K. : Histamine H₂-Receptor Antagonists, Acta Hepato-Gastroenterol. 23: 221 (June) 1976.

Parsons M. E. : The Antagonism of Histamine H₂-Receptors in vitro and in vivo with Particular Reference to the Actions of Cimetidine, Proceedings of The Second International Symposium on Histamine H₂-Receptor Antagonists, pp. 13–23 (Oct. 26–27) 1976.

Bunce K. T. : The Effect of Metiamide on Acid Secretion Stimulated by Gastrin, Acetylcholine and Dibutyryl Cyclic Adenosine 3', 5' Monophosphate in the Isolated Whole Stomach of the Rat, Br. J. Pharmacol. 58: 149 (Sept.) 1976.

Barth H. : Studies on the Mode of Action of Histamine H₁ and H₂-Receptor Antagonists on Gastric Histamine Methyl-transferase, Agents and Action 3: 138 (Feb.) 1973.

Sheperd D. M. : Effect of Metiamide on Histamine Metabolism in Man, Digestion 11: 307 (Apr.) 1974.

Griffiths R. : Kinetics of Cimetidine in Man and Experimental Animals, Proceedings of The Second International Symposium on Histamine H₂-Receptor Antagonists, pp. 38–53 (Oct. 26–27) 1976.

Personal Communication: Dr. Ralph Myerson, Smith, Kline and French Laboratories.

Burland W. L. : The Effect of Cimetidine Clearance on Renal Function, Proceedings of The Second International Symposium on Histamine H₂-Receptor Antagonists, pp. 67–74 (Oct. 26–27) 1976.

Canavan J. S. F. Briggs J. D. : Cimetidine Clearance in Renal Failure, Proceedings of The Second International Symposium on Histamine H₂-Receptor Antagonists, pp. 75–80 (Oct. 26–27) 1976.

Shapre P. C. Hawkins B. W. : Efficacy and Safety of Cimetidine — Long-Term Treatment with Cimetidine; Proceedings of The Second International Symposium on Histamine H₂-Receptor Antagonists, pp. 358–359 (Oct. 26–27) 1976.

Burland W. : Reversal of Metiamide Agranulocytosis During Treatment with Cimetidine, Lancet 2: 7944 (Nov. 29) 1975.

Leslie G. B. Walker T. F. : A Toxicology Profile of Cimetidine, Proceedings of The Second International Symposium on Histamine H₂-Receptor Antagonists, pp. 24–33 (Oct. 26–27) 1976.

Editorial: Cimetidine and Ulcers, Br. Med. J. 6047: 1275 (Nov. 27) 1976.

Burland W. L. : Effect of Cimetidine on Intrinsic Factor Secretion, Proceedings of The Second International Symposium on Histamine H₂-Receptor Antagonists, pp. 177–183 (Oct. 26–27) 1976.

Freeland : Lower Esophageal Sphincter Pressure Response to Oral Administration of Cimetidine in Normal Subjects, Gastroenterology 72: 28–30, 1977.

Pounder R. : Twenty-Four Hour Control of Intragastric Acidity by Cimetidine in Duodenal Ulcer Patients, Lancet 2: 1069–1072 (Nov. 29) 1975.

Longstreth G. F. : Postprandial Gastric, Pancreatic and Biliary Response to Histamine H₂-Receptor Antagonists in Active Duodenal Ulcer, Gastroenterology 72: 9–13, 1977.

Richardson C. T. : The Effect of Cimetidine, A New Histamine H₂-Receptor Antagonist, on Meal-Stimulated Acid Secretion, Serum Gastrin, and Gastric Emptying in Patients with Duodenal Ulcer, Gastroenterology 71: 19–23, 1976.

Richardson C. T. : Effect of an H₂-Receptor Antagonist on Food-Stimulated Acid Secretion, Serum Gastrin, and Gastric Emptying in Patients with Duodenal Ulcers; Comparison with Anticholinergic Drug, J. Clin. Invest. 55: 536–542 (Mar.) 1975.

Richardson C. T. Fordtran J. S. : Effect of Cimetidine, A New Histamine H₂-Receptor Antagonist on Food-Stimulated Acid Secretion in Duodenal Ulcer Patients, Gastroenterology 68: 972 (Apr.) 1975.

Aadland E. : Inhibition of Pentagastrin-Stimulated Gastric Secretion by Cimetidine in Healthy Subjects, Proceedings of The Second International Symposium on Histamine H₂-Receptor Antagonists, pp. 87–97 (Oct. 26–27) 1976.

Cano R. : Cimetidine Inhibits Caffeine-Stimulated Gastric Acid Secretion in Man, Gastroenterology 70: 1055–1057, 1976.

Bodemar G. : Cimetidine in the Treatment of Active Peptic Ulcer Diseases, Proceedings of The Second International Symposium on Histamine H₂-Receptor Antagonists, pp. 224–239 (Oct. 26–27) 1976.

Gray G. R. : Oral Cimetidine in Severe Duodenal Ulceration; A Double-Blind Controlled Trial, Lancet 1: 4–7 (Jan. 1) 1977.

Domschke W. : Double-Blind Study of Cimetidine in Patients with Duodenal Ulceration; Clinical Kinetic and Gastric and Pancreatic Secretory Data, Proceedings of The Second International Symposium on Histamine H₂-Receptor Antagonists, pp. 217–223 (Oct. 26–27) 1976.

A Multicentre Trial; Treatment of Gastric Ulcer by Cimetidine, Proceedings of The Second International Symposium on Histamine H₂-Receptor Antagonists, pp. 287–291 (Oct. 26–27) 1976.

Logan R. F. Forrest J. : Cimetidine, Metiamide and Gastric Ulcer, Lancet 1: 650 (Mar. 20) 1976.

Semb L. S. : Double-Blind Multicentre Comparative Study of Cimetidine and Placebo in Short-Term Treatment of Active Duodenal Ulceration, Proceedings of The Second International Symposium on Histamine H₂-Receptor Antagonists, pp. 248–259 (Oct. 26–27) 1976.

McDougall B. R. D. : H₂-Receptor Antagonists and Antacids in the Prevention of Acute Gastrointestinal Hemorrhage in Fulminant Hepatic Failure, Lancet 1: 627 (Mar. 19) 1977.

Blackwood V. S. : Cimetidine in Duodenal Ulcer, Lancet 2: 174–176 (July) 1976.

Bodemar G. Walan A. : Cimetidine in the Treatment of Active Duodenal and Prepyloric Ulcers, Lancet 2: 161–164 (July) 1976.

Spence R. W. : Influence of a Meal on the Absorption of Cimetidine, Digestion 14: 127–132, 1976.

Craven E. R. Whittington J. M. : Agranulocytosis Four Months After Cimetidine Therapy, Lancet 2: 294 (Aug. 6) 1977.