CaranasosG. J.: Drug-Induced Illness Leading to Hospitalization, J. Am. Med. Assoc.228: 713–717, 1974.
2.
HurwitzN.: Predisposing Factors in Adverse Reactions to Drugs, Br. Med. J.1: 536–539, 1969.
3.
MillerR. R.: Drug Surveillance Utilizing Epidemiologic Methods: A Report from the Boston Collaborative Drug Surveillance Program, Am. J. Hosp. Pharm.30: 584–592, 1973.
4.
BenderA. D.: Pharmacodynamic Principles of Drug Therapy in the Aged, J. Am. Geriatr. Soc.22: 296–303, 1974.
5.
BenderA. D.: Pharmacologic Aspects of Aging: A Survey of the Effect of Increasing Age on Drug Activity in Adults, J. Am. Geriatr. Soc.12: 114–134, 1964.
6.
RitschelW. A.: Pharmacokinetic Approach to Drug Dosing in the Aged, J. Am. Geriatr. Soc.24: 344–354, 1976.
7.
CrooksJ.: Pharmacokinetics in the Elderly, Clin. Pharmacokinet.1: 280–296, 1976.
8.
HollowayD. A.: Drug Problems in the Geriatric Patient, Drug Intell. Clin. Pharm.8: 632–642, 1974.
9.
LamyP. P.KitlerM. E.: The Geriatric Patient: Age-Dependent Physiologic Changes, J. Am. Geriatr. Soc.19: 23–33, 1971.
10.
LamyP. P.KitlerM. E.: The Geriatric Patient: Age-Dependent Physiologic and Pathologic Changes, J. Am. Geriatr. Soc.19: 871–879, 1971.
11.
HallM. R. P.: Drug Therapy in the Elderly, Br. Med. J.4: 582–584, 1973.
12.
KennedyR. D.: Drug Therapy for Cardiovascular Disease in the Aged, J. Am. Geriatr. Soc.23: 113–120, 1975.
13.
RaskindM.EisdorferC.: “Psychopharmacology of the Aged”, in SimpsonL. L. (Ed.): Drug Treatment of Mental Disorders, Raven Press, New York, pp. 237–266, 1976.
14.
HallM. R. P.: Use of Drugs in Elderly Patients, New York State J. Med.75: 67–71, 1975.
15.
BriantR. H.: The Rate of Acetaminophen Metabolism in the Elderly and the Young, J. Am. Geriatr. Soc.24: 359–361, 1976.
16.
TriggsE. J.: Pharmacokinetics in the Elderly, Eur. J. Clin. Pharmacol.8: 55–62, 1975.
17.
JickH. D.: Efficacy and Toxicity of Heparin in Relation to Age and Sex, N. Engl. J. Med.279: 284–286, 1968.
18.
ViewegW. V. R.: Complication of Intravenous Administration of Heparin in Elderly Women, J. Am. Med. Assoc.213: 1303–1306, 1970.
19.
HayesM. J.: Changes in Drug Metabolism with Increasing Age: I. Warfarin Binding and Plasma Proteins, Br. J. Clin. Pharmacol.2: 69–72, 1975.
20.
HewickD. S.: The Effect of Age on the Sensitivity to Warfarin Sodium, Br. J. Clin. Pharmacol.2: 189P–190P, 1975.
21.
O'MalleyK.: Factors Influencing Anticoagulant Control: An Epidemiological Study, in Drug Interactions, MorselliGarattiniCohen (Eds.), Raven Press, New York, pp. 309–317, 1974.
22.
KirbyJ. D.MarriottP. J.: Skin Necrosis Following Warfarin Therapy, Br. J. Dermatol.94: 97–99, 1976.
23.
Koch-WeserJ.: Coumarin Necrosis. Ann. Intern. Med.68: 1365, 1968.
24.
NudelmanH. L.KempsonR. L.: Necrosis of the Breast: A Rare Complication of Anticoagulant Therapy, Am. J. Surg.111: 728–733, 1966.
25.
The Boston Collaborative Drug Surveillance Program: Diphenylhydantoin Side Effects and Serum Albumin Levels, Clin. Pharmacol. Ther.24: 529–532, 1973.
26.
ReidenbergM. M.: Protein Binding of Diphenylhydantoin and Desmethylimipramine in Plasma from Patients with Poor Renal Function, N. Engl. J. Med.285: 264–267, 1971.
27.
HooperW. D.: Plasma Binding of Diphenylhydantoin: Effects of Sex Hormones, Renal and Hepatic Disease, Clin. Pharmacol. Ther.15: 276–282, 1974.
28.
BenderA. D.: Plasma Protein Binding of Drugs as a Function of Age in Adult Human Subjects, J. Pharm. Sci.64: 1711–1713, 1975.
29.
HoughtonG. W.: Effect of Age, Height, Weight and Sex on Serum Phenytoin Concentration in Epileptic Patients, Br. J. Clin. Pharmacol.2: 251–256, 1975.
30.
HayesM. J.: Changes in Drug Metabolism with Increasing Age: 2. Phenytoin Clearance and Protein Binding, Br. J. Clin. Pharmacol.2: 73–79, 1975.
31.
DaviesR. K.: Confusional Episodes and Anti-depressant Medication, Am. J. Psychiatry128: 127–131, 1971.
32.
FryJ.: Natural History of Hypertension: A Case for Selective Non-Treatment, LancetII: 431–433, 1974.
33.
JacksonG.: Inappropriate Antihypertensive Therapy in the Elderly, LancetII: 1317–1318, 1976.
34.
SchwidS.A.: The Use and Abuse of Antihypertensive Drugs in the Aged, Geriatrics22: 172–182, 1967.
35.
GurwithH. R.: Diarrhea Association with Clindamycin and Ampicillin Therapy: Preliminary Results of a Cooperative Study, J. Infect. Dis.135 (suppl.):S104–S109, 1977.
36.
HobermanL. J.: Colitis Associated with Oral Clindamycin Therapy: A Clinical Study of 16 Patients, Dig. Dis.21: 1–17, 1976.
37.
NeuH. C.: Incidence of Diarrhea and Colitis Associated with Clindamycin Therapy, J. Infect. Dis.135 (suppl.):S120–S125, 1977.
38.
SwartzbergJ. E.: Clinical Study of Gastrointestinal Complications Associated with Clindamycin Therapy, J. Infect. Dis.135 (suppl.):S99–S103, 1977.
39.
WellsR. F.: Clindamycin-Associated Colitis, Ann. Intern. Med.81: 547–548, 1977.
SchumacherG. E.: Practical Pharmacokinetic Techniques for Drug Consultation and Evaluation. IV: Gentamicin Blood Level Versus Time Profiles of Various Dosage Regimens Recommended for Renal Impairment, Am. J. Hosp. Pharm.32: 299–308, 1975.
45.
SchumacherG. E.: Pharmacokinetic Analysis of Gentamicin Dosage Regimens Recommended for Renal Impairment, J. Clin. Pharmacol.15: 656–664, 1975.
46.
KristensenM.: Drug Elimination and Renal Function, J. Clin. Pharmacol.15: 307–308, 1974.
47.
CutlerR. E.OrmeB. M.: Correlation of Serum Creatinine Concentration and Kanamycin Half-Life, J. Am. Med. Assoc.209: 539–542, 1969.
48.
MawerG. E.: Nomogram for Kanamycin Dosage, Lancet2: 45, 1972.
49.
LeikolaE.VartiaK. O.: On Penicillin Levels in Young and Geriatric Subjects, J. Gerontology15: 48–52, 1957.
50.
HansenJ. M.: Renal Excretion of Drugs in the Elderly, Lancet1: 1170, 1970.
51.
VartiaK. O.LeikolaL.: Serum Levels of Antibiotics in Young and Old Subjects Following Administration of Dihydrostreptomycin and Tetracycline, J. Gerontology18: 392–394, 1960.
52.
BurkleW. S.: Tobramycin and Gentamicin: A Comparison, Drug Intell. Clin. Pharm.10: 43–47, 1976.
53.
BechtolL. D.BlackH. R.: Tobramycin in Renal Impairment, Am. J. Med. Sci.269: 317–321, 1975.
54.
ChabnerB. A.: The Clinical Pharmacology of Antineoplastic Agents, Part 2, N. Engl. J. Med.292: 1159–1163, 1975.
55.
DallJ. L. C.: Digitalis Intoxication in Elderly Patients, Lancet1: 194–195, 1965.
56.
EwyG. A.: Digoxin Metabolism in the Elderly, Circulation39: 449–453, 1969.
57.
EwyG. A.: Digoxin Metabolism in Obesity, Circulation44: 810–814, 1971.
58.
HerrmannG. R.: Digitoxicity in the Aged: Recognition, Frequency, and Management, Geriatrics21: 109–122, 1966.
59.
JelliffeR. W.: Factors to Consider in Planning Digoxin Therapy, J. Chron. Dis.24: 407–416, 1971.
60.
CastledenC. M.: The Effect of Age on Plasma Levels of Propranolol and Practolol in Man, Br. J. Clin. Pharmacol.2: 303–306, 1975.
61.
EvansG. H.: The Disposition of Propranolol. III. Decreased Half-Life and Volume of Distribution as a Result of Plasma Binding In Man, Monkey, Dog, and Rat, J. Pharmacol. Exp. Ther.186: 114–122, 1973.
62.
GreenblattD. J.Koch-WeserJ.: Adverse Reactions to Propranolol in Hospitalized Medical Patients: A Report from the Boston Collaborative Surveillance Program, Am. Heart J.86: 478–484, 1973.
63.
GradB.: Effects of Levodopa Therapy in Patients with Parkinson's Disease: Statistical Evidence for Reduced Tolerance in the Elderly, J. Am. Geriatr. Soc.22: 489–494, 1974.
64.
RiklanM.: An L-Dopa Paradox: Bipolar Alterations, J. Am. Geriatr. Soc.20: 572–575, 1972.
65.
WenerJ.: Cardiovascular Effects of Levodopa in Aged versus Younger Patients with Parkinson's Disease, J. Am. Geriatr. Soc.24: 185–188, 1976.
66.
ChanK.: The Effect of Aging on Plasma Pethidine Concentration, Br. J. Clin. Pharmacol.2: 297–302, 1975.
67.
MatherL. E.: Meperidine Kinetics in Man: Intravenous Injection in Surgical Patients and Volunteers, Clin. Pharmacol. Ther.17: 21–30, 1975.
68.
BellvilleJ. W.: Influence of Age on Pain Relief from Analgesics: A Study of Postoperative Patients, J. Am. Med. Assoc.217: 1835–1841, 1971.
69.
BerkowitzB. A.: The Disposition of Morphine in Surgical Patients, Clin. Pharmacol. Ther.17: 629–635, 1975.
70.
IrvineR. E.: The Effect of Age on the Hydroxylation of Amylobarbitone Sodium in Man, Br. J. Clin. Pharmacol.1: 41–43, 1974.
71.
PattisonJ. H.AllenR. P.: Comparison of the Hypnotic Effectiveness of Secobarbital, Pentobarbital, Methyprylon and Ethchlorvynol, J. Am. Geriatr. Soc.20: 398–402, 1972.
72.
StotskyB. A.: Sodium Butabarbital (Butisol Sodium) as an Hypnotic Agent for Aged Psychiatric Patients with Sleep Disorders, J. Am. Geriatr. Soc.19: 860–870, 1971.
73.
JonesT. H.: Chlordiazepoxide (Librium®) and the Geriatric Patient, J. Am. Med. Assoc.175: 259–263, 1971.
74.
The Boston Collaborative Drug Surveillance Program: Clinical Depression of the Central Nervous System due to Diazepam and Chlordiazepoxide in Relation to Cigarette Smoking and Age, N. Engl. J. Med.288: 277–280, 1973.
75.
de LemosG. P.: Effects of Diazepam Suspension in Geriatric Patients Hospitalized for Psychiatric Illnesses, J. Am. Geriatr. Soc.13: 355–359, 1965.
76.
KlotzU.: The Effects of Age and Liver Disease on the Disposition and Elimination of Diazepam in Adult Man, J. Clin. Invest.55: 347–359, 1975.
77.
GreenblattD. J.: Toxicity of High-Dose Flurazepam in the Elderly. Clin. Pharmacol. Ther.21: 355–361, 1977.
78.
CastledenC. M.: Increased Sensitivity to Nitrazepam in Old Age, Br. Med. J.1: 10–12, 1977.
79.
EvansJ. G.JarvisE. H.: Nitrazepam and the Elderly, Br. Med. J.II: 487, 1972.
80.
HewickD. S.NewburyP. A.: Age: Its Influence on Lithium Dosage and Plasma Levels, Br. J. Clin. Pharmacol.3: 354, 1976.
81.
Van Der VelderC. D.: Toxicity of Lithium Carbonate in Elderly Patients, Am. J. Psychiatry127: 115–117, 1971.
82.
AydF. J.Jr.: A Survey of Drug-Induced Extrapyramidal Reactions, J. Am. Med. Assoc.175: 1054–1060, 1961.
83.
PaulsonG. W.: “Permanent” or Complex Dyskinesias in the Aged, Geriatrics23: 105–110, 1968.
