To determine the incidence of diarrhea and colitis associated with antibiotic therapy, a retrospective study utilizing chart reviews, autopsy reports and questionnaires was undertaken. Matched groups of patients who had received clindamycin, tetracycline, or chloramphenicol were studied. The incidence of diarrhea was similar for each group. No instances of colitis were identified. Clindamycin produced no more diarrhea than other antibiotics.
TedescoF. D.BartonR. W.AlpersD. H.: Clindamycin-Associated Colitis: A Prospective Study, Ann. Intern. Med.81: 429–433, 1974.
5.
ReinerL.SchlesingerM. D.MillerG. M.: Pseudomembranous Colitis Following Aureomycin and Chloramphenicol, Arch. Path.54: 39, 1952.
6.
BennerE. J.TellmanW. H.: Pseudomembranous Colitis as a Sequel to Oral Lincomycin Therapy, Am. J. Gastroenterol.54: 55–58, 1970.
7.
ScottA. J.NicholsonG. I.KerrA. R.: Lincomycin as a Cause of Pseudomembranous Colitis, Lancet2: 1232–1233, 1973.
8.
NewmanC. R.: Pseudomembranous Enterocolitis and Antibiotics, Ann. Intern. Med.45: 409–443, 1956.
9.
KeatingJ. P.FrankA. L.BartonL. L.TedescoF. J.: Pseudomembranous Colitis Associated with Ampicillin Therapy, Am. J. Dis. Child.128: 369–370, 1974.
10.
Ramirez-RandaC. H. (Letter): Incidence of Clindamycin-Associated Colitis, Ann. Intern. Med.81: 860, 1974.
11.
The Upjohn Company: Letter to Physicians, Aug. 16, 1974.
12.
HobermanL. J.ErgenbrodtE. H.KlimanW. J.HughesL. R.NorgaardR. P.FordtramJ. S.: Colitis Associated with Oral Clindamycin Therapy, Am. J. Dig. Dis.21: 1–17, 1976.
13.
TedescoF. J.: Clindamycin-Associated Colitis, Am. J. Dig. Dis.21: 26–32, 1976.
14.
McKenzieM. W.StewartR. B.WeissC. F.CluffL. E.: A Pharmacist-Based Study of the Epidemiology of Adverse Drug Reactions in Pediatric Medicine Patients, Am. J. Hosp. Pharm.30: 898–903, 1973.
15.
MeiselJ. L.BergmanD.SaundersD. R.GaneyD.: Human Rectal Mucosa: Proctoscopic and Morphologic Changes Caused by Laxatives (Abstract), Gastroenterology70: 918, 1976.
16.
TedescoF. J.: Ampicillin-Associated Diarrhea - A Prospective Study. Am. J. Dig. Dis.20: 295–297, 1975.
