Schultz's Disease — Drug allergic agranulocytosis — Is a syndrome characterized by a sudden decrease in circulating granulocytes, necrotic lesions of the oral mucosa, and general symptoms of severe prostration. This is a life threatening condition which is thought to be caused by an immune mechanism. Although identification of specific antibodies has not been successful in all cases, clinical responses in many reports also suggest an allergic basis for this syndrome. The appearance of agranulocytosis is reported in a 79-year-old woman receiving three drugs associated with this dyscrasia. Identification of the most likely causative agent is discussed, and the importance of allergic drug reactions is demonstrated.
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