A simple graphical technique is developed to predict whether a solubilized drug solution will become supersaturated (and thus have a potential for precipitation) when it is diluted with water.
Get full access to this article
View all access options for this article.
References
1.
SchroederH. G.DeLucaP. P.: A Study on the In Vitro Precipitation of Poorly Soluble Drugs From Nonaqueous Vehicles in Human Plasma, Bull. Parenteral Drug Assoc.28: 1, 1974.
2.
YalkowskyS. H.ValvaniS. C.AmidonG. L.: Solubility of Nonelectrolytes in Polar Solvents IV. Nonpolar Drugs in Mixed Solvents, accepted for publication in J Pharm. Sci.65: 1488, 1976.
