Impaired Renal Function Secondary to Gentamicin — Identifying the Special Risk Patient

Abstract

Although gentamicin has been commercially available since 1969, reports concerning the incidence of nephrotoxicity from this drug and variables relating to this toxicity are still unclear and conflicting. In view of this, a prospective study of patients receiving gentamicin over a two month period was undertaken to determine the incidence of nephrotoxicity and to study the influence of several variables on the potential for developing gentamicin associated nephrotoxicity. The variables studied were patient's age; the total grams of gentamicin received; the total number of days the patient received gentamicin with a hemoglobin of less than 12 g%; sex; total days duration of therapy; hemoglobin prior to therapy; hematocrit prior to therapy; red blood cell count prior to therapy; albumin level prior to therapy; and if the patient received another potentially nephrotoxic drug concomitantly with gentamicin. Sixty patients in total were studied. However, in the “toxic” and “nontoxic” grouping process, seventeen patients were excluded from the study due to missing variables. Of the remaining sample, ten patients were classified as “toxic” and thirty-three were classified as “nontoxic.” Thus the incidence of nephrotoxicity was at least 10/60 or 16.7 percent. The data relating to the variables identified were analysed utilizing Chi-square, t-test, and multiple regression analyses. Two variables were found to be highly significant in relationship to the development of nephrotoxicity while receiving gentamicin therapy. These were (1) the albumin level prior to therapy (lower albumin level in the “toxic” group) and (2) the concomitant use of another potentially nephrotoxic drug. The mechanism behind the influence of albumin on gentamicin toxicity is unclear, but may be related to protein binding. The basis for nephrotoxicity relating to combined use of nephrotoxic drugs is probably additive or synergistic toxicity but this is also unclear.

Until larger prospective studies concerning gentamicin associated nephrotoxicity provide more meaningful information concerning the significance of the variables involved in this adverse reaction, caution is recommended when using this drug in the albumin deficient patient or in combination with nephrotoxic drugs. In addition, it is further recommended that in patients receiving gentamicin, renal function should be closely monitored and the dosage regimen determined accordingly.