Drug Evaluation Data

Product Information: Hoffmann — La Roche, Nutley, New Jersey.

Kaplan S. A. : Pharmacokinetic Profiles of Clonazepam in Dog and Humans and of Flunitiazepam in Dog, J. Pharm. Sci. 63: 527 (Apr.) 1974.

de Silva J. A. F. : Determination of Clonazepam and Flunitiazepam in Blood and Urine by Electron Capture GCL, J. Pharm. Sci. 63: 520 (Apr.) 1974.

Guerroro-Figueroa R. : Effects of Two Benzodiazepine Derivatives on Cortical and Subcortical Epileptogenic Tissues in the Cat and Monkey, I. Limbic System Structures, II. Cortical and Centren-Cephalic Structures. Curr. Ther. Res. 11: 27 (Jan.) 1969.

Blum J. E. : Pharmakologic und Toxikologie des Antiepileptikums Clonazepam, Arznetm-Forsch. 23: 377 (Mar.) 1973.

Guerrero-Figueroa R. : Electrophysiological Analysis of the Action of Four Benzodiazepine Derivatives on the Central Nervous System, In Proc. Int. Symposium Benzodiazepines, Milan, Italy, 1971, p. 32.

Data on File: Medical Department, Hoffmann-La Roche, Nutley, New Jersey.

Hooshmand H. : Intractable Seizures, Treatment with a New Benzodiazepine Anticonvulsant, Arch. Neurol. 27: 205 (Sept.) 1972.

Barnett A. M. : Treatment of Epilepsy with Clonazepam (R05-4023), S. A. Med. J. 47: 1683 (Sept.) 1973.

Gastant H. : Exceptional Anti-epileptic Properties of a New Benzodiazepine, Vie Med. 51: 5175–5176, 5183–5188, 1970.

Dreifuss F. E. : Serum Clonazepam Concentrations in Children with Absence Seizures, Neurol. 25: 255 (Mar.) 1975.

Naestoft J. : Assay and Pharmacokinetics of Clonazepam in Humans, Acta. Neurol. Scand. 49, Suppl. 53: 103, 1973.

Sjo O. : Pharmacokinetics and Side-Effects of Clonazepam and Its 7-Amino Metabolite in Man, Europ. J. Clin. Pharmacol. 8: 249 (Apr.) 1975.

Hanson R. A. : A New Anticonvulsant in the Management of Minor Motor Seizures, Dev. Med. Child. Neurol. 14: 3–14 (Feb.) 1972.

Dumermuth G. : The Effect of Clonazepam (R05-4023) in the Syndrome of Infantile Spasms of Hypsarrhythmia and in Petit Mal Variant or Lennox Syndrome, Acta. Neurol. Scand. 49, Suppl. 53: 26–28, 1973.

Bladin P. F. : The Use of Clonazepam as an Anticonvulsant, Med. J. Aust. 1: 683 (Apr.) 1973.

Aarli J. A. : Effect of Clonazepam (R05-4023) on Epileptic Seizures, Acta. Neurol. Scand. 49, Suppl. 53: 11–17, 1973.

Fazio C. : Treatment of Epileptic Seizures with Clonazepam, Arch. Neurol. 32: 304–307 (May) 1975.

Gastant H. : Treatment of Status Epilepticus with a New Benzodiazepine More Active Than Diazepam, Epilepsia 12: 197 (Mar.) 1971.

Martin D. : Clinical Experience with Clonazepam (Rivotril) in the Treatment of Epilepsies in Infancy and Childhood, Neuropadiatrie 4: 245 (July) 1973.

Hollister L. : Dose-Ranging Studies of Clonazepam in Man, Psychopharmacol. Commun. 1: 89, 1975.

Lehtovaara R. : A Clinical Trial with Clonazepam (R05-4023), Acta. Neurol. Scand. 49: Suppl 53: 77–81, 1973.

Munth-Kaas A. W. : Clonazepam in the Traetment of Epileptic Seizures, Acta. Neurol. Scand. 49: Suppl. 53: 97, 1973.

Mikkelson B. : A Clinical Study of the Benzodiazepine R05-4023 (Clonazepam) in the Treatment of Epilepsy, Acta. Neurol. Scand. 49: Suppl. 53: 91, 1973.

Lund M. : Clonazepam in the Treatment of Epilepsy, Acta. Neurol. Scand. 49: Suppl. 53: 82–90, 1973.

Elian M. : The Rate of Dosage Increase of Clonazepam, Acta Neurol. Scand. 49: Suppl. 53: 32, 1973.

Birket-Smith E. : A Controlled Trial on R05-4023 (Clonazepam) In the Treatment of Psychomotor Epilepsy, Acta. Neurol. Scand. 49: Suppl. 53: 18–25, 1973.