A case of acute renal failure, hepatic dysfunction and skin and mucous membrane eruption following a course of sulfamethoxazole therapy is reported. Although several cases of multisystem reactions to long acting sulfonamides have been reported, this case describes the first such reaction to sulfamethoxazole.
The subsequent fatal outcome of this case demonstrates the potential significance of sulfamethoxazole hypersensitivity reactions.
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References
1.
BullG. M.JoekesA. M.LoweK. G.: Acute Renal Failure Due to Poisons and Drugs, Lancet1: 134–137, 1958.
2.
KinlawW. B.McCuneW. G.: Severe Reaction to Sulfadimethoxine, Am. J. Med. Sci.242: 30–31, 1961.
3.
GoldsweigH.WhipplingerC.: Severe Multisystem Allergic Reaction to Sulfisoxazole, Med. Ann. D.C.42: 334–338, 1973.
4.
ShawD. J.JacobsR. P.: Simultaneous Occurrence of Toxic Hepatitis and Stevens-Johnson Syndrome Following Therapy with Sulfisoxazole and Sulfamethoxazole, Johns Hopkins Med. J.126: 130–133, 1970.
5.
AngervallL.: Renal Diseases Caused by Drugs, In Hypersensitivity to Drugs Sec. 75, Vol. I, Chapter 10. International Encyclopedia of Pharmacology and Therapeutics, Pergamon Press, New York, 1972.
6.
FrenchA. J.: Hypersensitivity in the Pathogenesis of the Histopathologic Changes Associated with Sulfonamide Chemotherapy, Am. J. Pathol.22: 679–702, 1946.
RollinghoffW.: Allergische Nierenschadiging Durch Sulfonamide, Klin. Wochenschr.27: 553–558, 1949.
9.
MoreR. H.McMillanG. C.DuffG. L.: The Pathology of Sulfonamide Allergy in Man, Am. J. Pathol.22: 703, 1946.
10.
LehrD.: Sulfonamide Vasculitis, J. Clin. Pharmacol.12: 181–189, 1972.
11.
LedererM.RosenblattP.: Death During Sulfathiazole Therapy, J. Am. Med. Assoc.119: 8–18, 1942.
12.
MerkelW. C.CrawfordR. C.: Pathologic Lesions Produced by Sulfathiazole, J. Am. Med. Assoc.119: 770–776, 1942.
13.
Koch-WeserJ.: Adverse Reactions to Sulfisoxazole, Sulfamethoxazole and Nitrofurantoin, Arch. Intern. Med.128: 399, 1971.
14.
DujouneC. A.: Sulfonamide Hepatic Injury — Review of the Literature and Report of a Case Due to Sulfamethoxazole, N. Engl. J. Med.277: 785, 1967.
15.
FriesJ.SiraganianR.: Sulfonamide Hepatitis: Report of a Case Due to Sulfamethoxazole and Sulfisoxazole, N. Engl. J. Med.274: 95–97, 1966.
16.
HoffmanF. G.: Cholangiolitic Hepatitis: Case Report and Review, Gastroenterology29: 247, 1955.
17.
MacoulK. L.: Hepatitis Attributed to Sulfamethoxazole, N. Engl. J. Med.275: 39, 1966.
18.
TisdaleW. A.: Food Hepatitis, Fever and Skin Rash Following Therapy with Sulfamethoxypyridine, a Long-Acting Sulfonamide, N. Engl. J. Med.258: 637–690, 1938.
19.
Case Records of the Massachusetts General Hospital (Case 37-1965), N. Engl. J. Med.273: 440–446, 1965.
20.
Case Records of the Massachusetts General Hospital (Case 6-1965), N. Engl. J. Med.272: 254–259, 1965.
21.
Bianchine: Drugs as Etiologic Factors in the Stevens-Johnson Syndrome, Am. J. Med.44: 390, 1968.
