A case involving suspected digoxin malabsorption is presented. Two clinical tests of malabsorption, D-xylose and serum carotene are explained. Several pharmacokinetic calculations are made to theoretically predict the patient's serum digoxin concentration. Other data is presented to compare with the patient's response. The significance of altered renal function and bioavailability of digoxin are discussed and the relationship between hyperthyroidism and serum digoxin determinations is mentioned. Several alternative therapies for use in cases of malabsorption are discussed.
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