Drug Evaluation Data

Amoxicillin , (Larocin) Package Circular, (Feb.) 1974.

Long A. A. W. : Derivatives of 6-aminopenicil-lanic acid. Part XI. α-amino-p-hydroxybenzyl-penicillin, J. Chem. Soc., Section C, pp. 1920–1922, 1971.

Comprehensive Product Information, Larocin (amoxicillin) Roche Laboratories, pp. 1–2, (Feb.) 1974.

Sutherland R. Rolinson G. N. : α-amino-p-hydroxybenzyl-penicillin (BRL 2333), a New Semisynthetic Penicillin: In Vitro Evaluation, Antimicrobial Agents Chemother., pp. 411–415, 1970.

Rolinson G. N. Stevens S. : Micro-Biological Studies on a New Broad-Spectrum Penicillin, “Penbritin,” Brit. Med. J. 2: 191–196, 1961.

Neu H. C. Winshell E. G. : In Vitro Antimicrobial Activity of 6[D(-)α-Amino-p-Hydroxyphenylacetamido] Penicillanic Acid, a New Semisynthetic Penicillin, Antimocrobial Agents Chemother., pp. 407–410, 1970.

Croydon E. A. P. Sutherland R. : Microbiology and Human Pharmacology of Amoxycillin (BRL 2333), in Hetzlar M. Semonsky M. Masak S. Advances in Antimicrobial and Antineoplastic Chemotherapy, Volume I/2, Baltimore, University Park Press, pp. 975–979, 1972.

Croydon E. A. P. Sutherland R. : α-Amino-p-Hydroxybenzyl-Penicillin (BRL 2333), a New Semisynthetic Penicillin: Absorption and Excretion in Man, Antimicrobial Agents Chemother., pp. 427–430, 1970.

Gordon R. C. Regamey C. Kirby W. M. M. : Comparative Clinical Pharmacology of Amoxicillin and Ampicillin Administered Orally, Antimicrobial Agents Chemother., pp. 504–507, 1972.

Jusko W. J. : Ampicillin and Hetacillin Pharmacokinetics in Normal and Anephric Subjects, Clin. Pharmacol. Ther. 14: 90 (Jan.-Feb.) 1973.

Ruedy J. : The Effects of Peritoneal Dialysis on the Disposition of Oxacillin, Ampicillin and Tetracycline in Renal Disease, Can. Med. Assoc. J. 94: 257 (Feb. 5) 1966.

Leigh D. A. : Diagnosis of Urinary Tract Infections in General Practice and Treatment with a New Penicillin-Amoxicillin, Curr. Med. Res. Opin. 1: 10–18, 1972.

Kerrebijn K. F. Michel M. F. : Amoxicillin (BRL 2333) in Children, Chemotherapy 18: 92–96, 1973.

Simonian P. L. Verhoef J. : The Pharmacokinetics of Amoxicillin and Flucloxicillin in Patients with Terminal Renal Failure Undergoing Hemodialysis, Antonie Van Leeuwenhoek 39: 655, 1973.

Sabto J. : Absorption and Therapeutic Effect of Amoxicillin (Abstract of Study Supplied by Beecham Labs).

Kosmidis J. : Amoxicillin-Pharmacology, Bacteriology and Clinical Studies, Brit. J. Clin. Pract. 26: 341–346, 1972.

Mortimer P. R. : Ampicillin Levels in Human Bile in Presence of Biliary Tract Disease, Brit. Med. J. iii: 88, 1969.

Ayliffe G. Davies A. : Ampicillin Levels in Human Bile, Brit. J. Pharmacol. 24: 189, 1965.

Personal Communication, Hoffman-LaRoche, Inc., (May 8) 1974.

Willcox P. P. : Amoxicillin in the Treatment of Gonorrhoea, Brit. J. Venereal. Dis. 48: 504–509, 1972.

Karney W. W. Turck M. Holmes K. K. : Comparative Evaluation of Ampicillin Plus Probenecid, And Amoxicillin for Treatment of Gonorrhea, in Proceedings XIII Interscience Conference on Antimicrobial Agents Chemotherapy at Washington, p. 68, 1973.

Deal W. B. : Single Dose Amoxicillin Therapy of Uncomplicated Male Gonococcal Urethritis, In Proceedings XII Interscience Conference on Antimicrobial Agents Chemotherapy at Atlantic City, p. 65, 1972.

Jones G. R. : Amoxycillin: Pilot Study of Its Use in Pneumonia and Chronic Bronchitis, Brit. J. Clin. Pract. 27: 161–164, 1973.

May J. R. Ingold A. : Amoxycillin in the Treatment of Chronic Non-Tuberculous Bronchial Infections, Brit. J. Dis. Chest. 66: 185–191, 1972.

Burgi H. : Clinical and Experimental Experience with Amoxicillin in Chronic Bronchitis, Chemotherapy 18: Suppl 19, 1973.

Harding J. W. Lees L. J. : Trial of a New Broad-Spectrum Penicillin (Amoxycillin) in General Practice, Practitioner 209: 363–368, 1972.

Guibert J. M. C. Acar J. F. : Clinical and Bacteriological Evaluation of Amoxicillin Excluding Infections Due to Entero-bacteria, Chemotherapy 18: Suppl 81–90, 1973. Translation from French supplied by Information Company of America, 2204 Walnut St., Phila., Pa., through Roche Laboratories.

Luttecke K. : The Testing of Amoxicillin (BRL 2333) Under the Conditions of General Practice, Chemotherapy 18: Suppl 12, 1973.

Eubanks N. Jackson J. Gilber D. N. : Double-Blind Treatment of Urinary Tract Infections Comparing Ampicillin and Amoxicillin, in Proceedings XII Interscience Conference on Antimicrobial Agents Chemotherapy at Atlantic City, p. 80, 1972.

Middleton F. G. Poretz D. M. Duma R. J. : Clinical and Laboratory Evaluation of Amoxicillin (BRL 2333) in the Treatment of Urinary Tract Infections, Antimicrobial Agents Chemother. 4: 25–30, 1973.

The Clinical Evaluation of Larocin® (amoxicillin), Roche Scientific Summary, Hoffman-LaRoche, Inc., 1974.

Levine B. : Management of Skin Rashes Due to Penicillin Therapy, New Engl. J. Med. 286: 42 (Jan.) 1972.

Kerns D. : Ampicillin Rash in Children, Amer. J. Dis. Child. 125: 187 (Feb.) 1973.

Dubb S. : Amoxycillin Rash, South African Med. J. 47: 1218, 1973.

Hansten P. D. : Drug Interactions, 2nd Edition, Lea and Febiger, Philadelphia, p. 137, 1973.