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Abstract

Keywords

Drug Therapy Antibiotics Penicillins dotage Toxicology antibiotics Pharmacokinetics Ampicillin dosage Carbenicillin Cloxacillin Dicloxacillin Hetacillin Methicillin Nafcillin Oxacillin Penicillin G

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References

Kunin

C. M.

: A Guide to Use of Antibiotics in Patients With Renal Disease. A Table of Recommended Doses and Factors Governing Serum Levels, Ann. Intern. Med. 67: 151–158 (July) 1967.

Bulger

R. J.

, and Petersdorf

R. G.

: Antimicrobial Therapy in Patients With Renal Insufficiency, Postgrad. Med. 47: 160–165 (Jan.) 1970.

Wagner

J. G.

: Drug Accumulation, J. Clin. Pharmacol. New Drugs 7: 84–88 (Mar.-Apr.) 1967.

Hirschman

J. L.

, and Borgsdorf

L. R.

: The DIAS Rounds, Drug Intell. Clin. Pharm. 5: 249–251 (Aug.) 1971.

Goodman

L. S.

, and Gilman

: The Pharmacologic Basis of Therapeutics, ed. 4, The Macmillan Co., New York, 1970, p. 1225–1229.

Reilly

M.J.

: Penicillin G in American Hospital Formulary Services, American Society of Hospital Pharmacists, Washington, D.C., 1962, p. 8: 12.16.

Weinstein

: Clinical and Bacteriologic Studies of the Effect of “Massive” Doses of Penicillin G on Infections Caused by Gram-Negative Bacilli, N. E. J. Med. 271: 523–525 (Sept. 10) 1964.

New

P. S.

, and Wells

C. E.

: Cerebral Toxicity Associated With Massive Intravenous Penicillin Therapy, Neurology 15: 1053–1058 (Nov.) 1965.

Oldstone

M. B. A.

, and Nelson

: Central Nervous System Manifestations of Penicillin Toxicity in Man, Neurology 16: 693–700 (July) 1966.

10.

Bloomer

H.A.

: Penicillin-Induced Encephalopathy in Uremic Patients, J. Am. Med. Assoc. 200: 121–123 (Apr. 10) 1967.

11.

Smith

: Neurotoxicity and “Massive” Intravenous Therapy With Penicillin, Arch. Intern. Med. 120: 47–53 (July) 1967.

12.

Cohill

D.F.

: Central Nervous System Toxicity Secondary to Massive Doses of Penicillin G in the Treatment of Overwhelming Infections, Amer. J. Med. Sci. 42: 264–272 (Nov.) 1967.

13.

Borman

J. B.

, and Eynl

: Neurotoxic Effects of Large Doses of Penicillin Administered Intravenously, Arch. Surg. 97: 662–665 (Oct.) 1968.

14.

Conway

: Penicillin Encephalopathy, Postgrad. Med. 44: 891–897 (Dec.) 1968.

15.

Lavy

, and Stein

: Convulsions in Septicemic Patients Treated With Penicillin, Arch. Surg. 100: 225–228 (Mar.) 1970.

16.

Raichle

M.E.

: Neurotoxicity of Intravenously Administered Penicillin G, Arch. Neur. 25: 232–239 (Sept.) 1971.

17.

Med. Letter Drugs Ther. 14: 11–14 (Jan. 21) 1972.

18.

Lewis

G. P.

, and Jick

: Drug Rash With Ampicillin and Other Penicillins, Lancet 2: 969–972 (Nov. 8) 1969.

19.

Gruneberg

R. N.

, and Brumfitt

: Single Dose Treatment of Acute Urinary Tract Infections: A Controlled Trial, Brit. Med. J. 3: 649–651 (Sept. 9) 1967.

20.

Lee

H. A.

, and Hill

L. F.

: The Use of Ampicillin in Renal Disease, Brit. J. Clin. Pract. 22: 354–357 (Aug.) 1968.

21.

Fingehold

S.M.

: Chemotherapy Guide, Calif. Med. 111: 362–387 (Nov.) 1969.

22.

Reubi

, and Vorburger

: Renal and Extrarenal Excretion of Ampicillin in Patients With Normal and Impaired Renal Function, Pharmacol. Clin. 1: 192–202 (June) 1969.

23.

Maher

J. F.

, and Schreiner

G. E.

: The Dialysis of Poisons and Drugs, Trans. Amer. Soc. Artif. Intern. Organs 13: 369–393, 1967.

24.

Tuano

S.P.

: Comparative Blood Levels of Hetacillin, Ampicillin, and Penicillin G, N. E. J. Med. 275: 635–639 (Sept. 22) 1966.

25.

Ruedy

: The Effects of Peritoneal Dialysis on the Physiological Disposition of Oxacillin, Ampicillin, and Tetracycline in Patients With Renal Disease, Can. Med. Assoc. J. 94: 257–261 (Feb. 5) 1966.

26.

Kunin

C. M.

: Clinical Pharmacology of the New Penicillins. I. The Importance of Serum Protein Binding in Determining Antimicrobial Activity and Concentration in Serum, Clin. Pharmacol. Ther. 7: 166–179 (Mar.-Apr.) 1966.

27.

Plaut

M.E.

: Penicillin Handling in Normal and Azotemic Patients, J. Lab. Clin. Med. 74: 12–18 (July) 1969.

28.

Barnett

H.L.

: Renal Clearance of Sodium Penicillin G, Procaine Penicillin G, and Inulin in Infants and Children, Pediatrics 3: 418–422 (Apr.) 1949.

29.

Huang

N.N.

: Comparison of Serum Levels Following the Administration of Oral and Parenteral Preparations of Penicillin to Infants and Children of Various Age Groups, J. Pediat. 42: 657–668 (June) 1953.

30.

Kunin

C. M.

, and Maxwell

F. J.

: Persistence of Antibiotics in Blood of Patients With Acute Renal Failure. III. Penicillin, Streptomycin, Erythromycin and Kanamycin, J. Clin. Invest. 38: 1509–1519 (Sept.) 1959.

31.

Hoffler

: Ampicillin-Spiegel in Serum Und Harn bei Eingeschrankter Nierenfunktion, Deut. Med. Wochenschr. 91: 206–210 (Feb. 4) 1966.

32.

Marks

M. I.

, and Eickhoff

T. C.

: Carbenicillin: A Clinical and Laboratory Evaluation, Ann. Intern. Med. 73: 179–187 (Aug.) 1970.

33.

Smith

C.B.

: In Vitro Activity of Carbenicillin and Results of Treatment of Infections Due to Pseudomonas With Carbenicillin Singly and in Combination With Gentamicin, J. Infect. Dis. 122 (suppl.): 514–524 (Sept.) 1970.

34.

Hoffman

T. A.

, and Bullock

W. E.

: Carbenicillin Therapy of Pseudomonas and Other Gram Negative Bacillary Infections, Ann. Intern. Med. 72: 165–171 (Aug.) 1970.

35.

Jones

R. J.

, and Lowbury

E. J. L.

: Prophylaxis and Therapy for Pseudomonas aeruginosa Infections With Carbenicillin and With Gentamicin, Brit. Med. J. 3: 79–82 (July 8) 1967.

36.

Lowbury

E. J. L.

: Sensitivity of Pseudomonas aeruginosa to Antibiotics: Emergence of Strains Highly Resistant to Carbenicillin. Lancet 2: 448–452 (Aug. 30) 1969.

37.

Brumfitt

: Clinical and Laboratory Studies With Carbenicillin. A New Penicillin Active Against Pseudomonas pyocyanea, Lancet 1: 1289–1293 (June 17) 1967.

38.

Standiford

H.C.

: Laboratory and Clinical Studies of Carbenicillin Against Gram Negative Bacilli, Antimicrob. Agents Chemother. 1968, 1969 p. 286–291.

39.

Smith

C.B.

: Use of Gentamicin in Combination With Other Antibiotics, J. Infect. Dis. 119: 370–377 (Apr.-May) 1969.

40.

Sonne

, and Jawetz

: Combined Action of Carbenicillin and Gentamicin on Pseudomonas aeruginosa In Vitro, Appl. Microbiol. 17: 895–896 (June) 1969.

41.

Eickhoff

T. C.

: In Vitro Effects of Carbenicillin Combined with Gentamicin or Polymyxin B Against Pseudomonas aeruginosa, Appl. Microbiol. 18: 469–473 (Sept.) 1969.

42.

Phair

J.P.

: In Vitro Susceptibility of Pseudomonas aeruginosa to Carbenicillin and the Combination of Carbenicillin and Gentamicin, Appl. Microbiol. 18: 303–306 (Sept.) 1969.

43.

Nunnery

A.W.

: Carbenicillin: In Vitro Synergism and Combined Therapy, J. Infect. Dis. 122 (suppl.): 578–583 (Sept.) 1970.

44.

Klastersky

: Antimicrobial Activity of the Carbenicillin/Gentamicin Combination Against Gram Negative Bacilli, Amer. J. Med. Sci. 260: 373–380 (Dec.) 1970.

45.

McLaughlin

J. E.

, and Reeves

D. S.

: Clinical and Laboratory Evidence for Inactivation of Gentamicin by Carbenicillin, Lancet 1: 261–264 (Feb.) 1971.

46.

Winters

R.E.

: Combined Use of Gentamicin and Carbenicillin, Ann. Intern. Med. 75: 925–927 (Dec.) 1971.

47.

Hoffman

T.A.

: Pharmacodynamics of Carbenicillin in Hepatic and Renal Failure, Ann. Intern. Med. 73: 173–178 (Aug.) 1970.

48.

Rosenblatt

J.E.

: Mechanisms Responsible for the Blood Level Differences of Isoxazolyl Penicillins, Arch. Intern. Med. 121: 345–348 (Apr.) 1968.

49.

Bulger

R.J.

: Effect of Uremia on Methicillin and Oxacillin Blood Levels. Excretion and Inactivation in Renal Failure and Hemodialysis, J. Am. Med. Assoc. 187: 319–322 (Feb. 1) 1964.

50.

Med. Letter Drugs Ther. 10: 65–66 (Aug. 23) 1968.

51.

De Felice

E. A.

: Serum Levels, Urinary Recovery, and Safety of Dicloxacillin, a New Semisynthetic Penicillin, in Normal Volunteers, J. Clin. Pharmacol. 7: 275–277 (Sept.-Oct.) 1967.

52.

Gravenkemper

C.F.

: Dicloxacillin. In Vitro and Pharmacologic Comparisons With Oxacillin and Cloxacillin, Arch. Intern. Med. 116: 340–345 (Sept.) 1965.

53.

Nauman

: Laboratory and Clinical Evaluation of Dicloxacillin, Antimicrob. Agents Chemother.—7965, 1966 p. 937–946.

54.

Hammerstrom

C.F.

: Clinical, Laboratory, and Pharmacological Studies of Dicloxacillin, Antimicrob. Agents Chemother.—1966, 1967 p. 69–74.

55.

Hartman

R.E.

: Effect of Dicloxacillin, Oxacillin, and Nafcillin Upon Staphylococcal Population and Rate of Healing of Soft-Tissue Lesions, Antimicrob. Agents Chemother.—1966, 1967 p. 64–68.

56.

McCloskey

R. V.

, and Hayes

: Plasma Levels of Dicloxacillin in Oliguric Patients and the Effect of Hemodialysis, Amer. Soc. Microbiol. Abstr. Papers, 7th Intersci. Conf., Antimicrob. Agents Chemother., Chicago, Ill. (Oct. 25–27) 1967: 43 (Abstr. 97). (De Haen Drugs in Use, #U4719/9).

57.

Sutherland

, and Robinson

O. P. W.

: Laboratory and Pharmacological Studies in Man With Hetacillin, Brit. Med. J. 2: 805–808 (June 24) 1967.

58.

Smith

J. T.

, and Hamilton-Miller

J. M. T.

: Hetacillin: A Chemical and Biological Comparison With Ampicillin, Chemotherapy 15: 366–378, 1970.

59.

Kirby

W. M. M.

, and Kind

A. C.

: Clinical Pharmacology of Ampicillin and Hetacillin, Ann. N. Y. Acad. Sci. 145: 291–297 (Sept. 27) 1967.

60.

Tuano

S.B.

: Comparative Blood Levels of Hetacillin, Ampicillin, and Penicillin G, N. E. J. Med. 275: 635–639 (Sept. 22) 1966.

61.

Ridley

: Hetacillin and Ampicillin, Brit. Med. J. 3: 305 (July 29) 1967.

62.

Gooding

P.G.

: Hetacillin Potassium Oral Solutions: Absorption of Pediatric Formulations, Curr. Ther. Res. 11: 690–694 (Nov.) 1969.

63.

Kahrimanis

, and Pierpaoli

: Hetacillin vs. Ampicillin, N. E. J. Med. 285: 236–237 (July) 1971.

64.

Allen

R.J.

: Drug Evaluation Data: Hetacillin, Drug Intel. Clin. Pharm. 5: 247–248 (Aug.) 1971.

65.

Scioli

, and Giusti

: Hetacillin in the Treatment of Typhoid Fever, Clin. Med. 74: 68–70 (Apr.) 1967.

66.

Magni

: Stability, Absorption and Excretion Studies With Hetacillin, Scand. J. Clin. Lab. Invest. 20: 195–201 (Nov.) 1967.

67.

Allen

J.D.

: Staphylococcal Septicemia Treated With Methicillin. Report of Twenty-two Cases, N. E. J. Med. 266: 111–116 (Jan.) 1962.

68.

Grattan

W. A.

: Hematuria and Azotemia Associated With Administration of Methicillin, J. Pediat. 64: 285–287 (Feb.) 1964.

69.

Schrier

R.W.

: Nephropathy Associated With Penicillin and Homologues, Ann. Intern. Med. 64: 116–127 (Jan.) 1966.

70.

Hodgin

V. G.

: Renal Insufficiency During Administration of Methicillin, Rocky Mountain Med. J. 63: 43–45 (Sept.) 1966.

71.

London

R. D.

: Hematuria Associated With Methicillin Therapy, J. Pediat. 70: 285–286 (Feb.) 1967.

72.

Filippini

, and Siegenthaler

: Nephropathy With Methicillin, Deut. Med. Wochenschr. 92: 395–397 (Mar. 3) 1967.

73.

Blanhinship

G. R.

: Methicillin Toxicity, S. Med. J. 61: 1344 (Dec.) 1968.

74.

Baldwin

D.S.

: Renal Failure and Interstitial Nephritis Due to Penicillin and Methicillin, N. E. J. Med. 279: 1245–1252 (Dec. 5) 1968.

75.

Brauninger

G. E.

, and Remington

J. S.

: Nephropathy Associated With Methicillin Therapy, J. Am. Med. Assoc. 203: 103–105 (Jan. 8) 1968.

76.

Semenhoff

M. L.

: Acute Diffuse Interstitial Nephritis, Amer. J. Med. 44: 618–625 (Apr.) 1968.

77.

Federman

M. J.

, and Lerner

A. M.

: Occurrence of Nephritis With Prolonged Administration of Methicillin, Clin. Res. 17: 539 (Oct.) 1969.

78.

Gallagher

P. J.

, and Wayne

D. J.

: Hematuria During Methicillin Therapy, Postgrad. Med. 47: 511–512 (July) 1971.

79.

Jensen

H.A.

: Permanent Impairment of Renal Function After Methicillin Nephropathy, Brit. Med. J. 4: 406 (Nov.) 1971.

80.

Roberts

C.E.

: Laboratory and Clinical Studies of Penicillin X-1497, Clin. Pharmacol. Ther. 2: 70–79 (Jan.-Feb.) 1961.

A Review of the Clinical Use of Antimicrobial Agents in Patients with Renal and Hepatic Insufficiency I. the Penicillins

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