Bioavailability in the Clinical Evaluation of Drugs

Levy G. : Bioavailability, Clinical Effectiveness, and the Public Interest, Conference on Bioavailability of Drugs, Washington, D.C., Nov. 22–23, 1971.

Riegelman S. : Clinical Evaluation of the Effect of Formulation Variables on Therapeutic Performance of Drugs, Drug Inform. Bull. 3: 59–67 (Jan.-June) 1969.

Levy L. Gelber R. : Influence of Systemic Availability on the Efficacy of Some Chemotherapeutic Agents, Drug Inform. Bull. 3: 82–92 (Jan.-June) 1969.

Brice G. W. Hammer H. F. : Therapeutic Non-equivalence of Oxytetracycline Capsules, J. Am. Med. Assoc. 208: 1189–1190 (May 19) 1969.

Levy G. : The Therapeutic Implications of Brand Interchange, Am. J. Hosp. Pharm. 17: 756–759, 1960.

Barr W. H. : Factors Involved in the Assessment of Systemic or Biologic Availability of Drug Products, Drug Inform. Bull. 3: 27–45 (Jan.-June) 1969.

Feinberg M. : Quality Standards and Testing of Drugs (Part 2), Hosp. Formul. Manag. 5: 8–10, 29 (Jan.) 1970.

Wagner J. G. : Biopharmaceutics and Relevant Pharmacokinetics, Drug Intelligence Publications, Hamilton, Ill. 1971, p. 166–179.

Ritschel W. A. : Physiological Availability in Applied Biopharmaceutics I , University of Cincinnati, Cincinnati, Ohio, 1969, p. 490–498.

Lamy P. P. : Factors Affecting Absorption and Availability of Drugs, Pharmacy Times 35: 32–38 (Dec.) 1969.

Oser B. L. Melnick D. Hochberg M. : Physiological Availability of the Vitamins. Study of Methods for Determining Availability in Pharmaceutical Products, Ind. Eng. Chem. Anal. Educ. 17: 401–411, 1945.

Levy G. : in Sprowls J. B. : Prescription Pharmacy. J. B. Lippincott Co., Philadelphia, 1963, p. 31–94.

Ritschel W. A. : Generic Versus Brand Name Prescribing, Therapeutic Consult, I : 1–2, 1969.

Ariëns E. J. : Molecular Pharmacology; the Mode of Action of Biologically Active Compounds. Academic Press, Inc., New York, 1964, vol. 1 p. 197.

Stephenson R. P. : A Modification of Receptor Theory Brit. J. Pharmacol. 11: 379–393, 1956.

Clark A. J. : in Heffter A. Heubner H. : Handbuch der Experimentellen Pharmakologie. Springer Verlag, Vienna, vol. 4, 1937.

Paton W. D. M. : A Theory of Drug Action Based on the Rate of Drug-Receptor Combination, Proc. Roy. Soc. Med. 154: 21–69, 1961.

Dost F. H. : Grundlagen der Pharmakokinetik, Georg Thieme Verlag, Stuttgart, 1968, p. 156–158.

Dost F. H. Gladtke E. : Die enterale Absorption schwer löslicher Sulfanilamide beim Kind, Arzneimittel-Forschung 17: 772–774, 1967.

Sokolnikoff I. S. Sokolnikoff S. : Higher Mathematics for Engineers and Physicists, ed 2. McGraw-Hill Book Co., New York, 1941, p. 555.

Wagner J. G. : Method of Estimating Relative Absorption of a Drug in a Series of Clinical Studies in Which Blood Levels are Measured After Single and/or Multiple Doses, J. Pharmaceut. Sci. 56: 652–653 (May) 1967.

Rescigno A. Segre G. : Drug and Tracer Kinetics. Blaisdell, Waltham, Mass. 1966, p. 102–114.

Loo J. C. K. Riegelman S. : Some Alternative Methods Calculating the Intrinsic Absorption Rate of Drugs, APhA Meeting, Academy of Pharmaceutical Sciences, San Francisco, 1971.

Ritschel W. A. : Distribution in Applied Biopharmaceutics I , University of Cincinnati, Cincinnati, Ohio, 1969 p. 218.

Diller W. Bünger P. : Zur Pharmakokinetik der rectalen Applikation, Arzneim. Forsch. 15: 1274–78, 1965.

Ritschel W. A. : Formulating Factors Which Influence Therapeutic Drug Response (in German), Österr. Apoth. Ztg. 24: 21, 1970.

Ritschel W. A. : Biopharmaceutical Development and Evaluation of Peroral Dosage Forms in Applied Biopharmaceutics II, University of Cincinnati, Cincinnati, Ohio, 1970, p. 824.

Poole J. W. : “Penicillins — Use of an Animal Model to Predict Bioavailability,” Fifth Annual Symposium, Perspectives in Bioavailability of Drugs — Therapeutic and Toxi-cological Significance, Montreal, December 1971.

Potassium Phenoxymethyl Penicillin Tablets in United States Pharmacopeia, ed. 18. Mack Publishing Co., Easton Pa., 1970, p. 526–527.

Giovannini M. : Wirkungsspektrum in Brunner R. MaChek G. : Die Antibiotica, Verlag Hans Carl, Nürnberg, 1962, vol 1., part 1, p. 410–414.

AMA Drug Evaluations, ed. 1. American Medical Association, Chicago, 1971, p. 394.

Nagashima R. O'Reilly R. A. Levy G. : Kinetics of Pharmacologic Effects in Man — The Anticoagulant Action of Warfarin, Clin. Pharmacol. Therap. 10: 22–35 (Jan.-Feb.) 1969.

Ritschel W. A. : Biopharmaceutics and the Future Practice of Pharmacy, Pharma Int. No. 1, 1 (Jan.) 1971.