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R — Review A — Animal Data O — Original Research H — Human Data CH — Case History T — In Vitro Data

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: Folic Acid and Phenytoin Metabolism, Lancet 1: 645 (Mar. 27) 1971. (OH) (Corres.).

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: The Rate of Decline of Diphenylhydantoin in Human Plasma, Clin. Pharmacol. Therap. 11: 121 (Jan.-Feb.) 1970. (OH).

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: Influence of Folic Acid on Blood-Phenytoin Levels, Lancet 1: 62 (Jan. 9) 1971. (OH).

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: Diphenylhydantoin Intoxication Attendant to Slow Inactivation of Isoniazid, Neurol. 20: 687 (July) 1970. (OHA).

Buchanan

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: The Effect of Phenobarbital on Diphenylhydantoin Metabolism in Children, Pediat. 43: 114 (Jan.) 1969. (OH).

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: Implications of Enzyme Induction for Drug Therapy, Am. J. Med. 37: 327 (Sept.) 1964. (Ed).

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Burns

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: Application of Drug Metabolism to Drug Toxicity Studies, Ann. N.Y. Acad. Sci. 123: 273 (Mar.) 1965. (R).

11.

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: Ceruloplasmin Rise and PBI Fall in Serum Due to Diphenylhydantoin, Arch. Neurol. 15: 393–396 (Oct.) 1966. (OHA).

12.

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: Inhibition of Drug Metabolism by Chloramphenicol, Lancet 2: 1397 (Dec. 27) 1969. (OH).

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A. H.

: Induction of Liver Microsomal Cortisol 6b-hydroxylate by Diphenylhydantoin or Phenobarbital: An Explanation for the Increased Excretion of 6-hydroxycortisol in Humans Treated With These Drugs, Life Sci. 4: 1091 (May) 1965.

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: Effects of Pesticides on Drug and Steroid Metabolism, Clin. Pharmacol. Therap. 8: 2 (Jan.-Feb.) 1968. (OA).

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: Stimulatory Effect of Phenobarbital on the Metabolism of Diphenylhydantoin, J. Pharmacol. Exptl. Therap. 141: 157 (Aug.) 1963.

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: Drug Interactions In Man: 1. Lowering Effect of Phenobarbital on Plasma Levels of Bishydroxycoumarin (Dicumarol) and Diphenylhydantoin (Dilantin), Clin. Pharmacol. Therap. 6: 420 (July-Aug.) 1965. (OAH).

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J. R.

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: Dilantin-Folic Acid Deficiency, Blood 30: 341 (Sept.) 1967. (AOH).

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: Effect of Anticonvulsant Drugs on Dicophane (DDT) Residues in Man, Lancet 2: 7 (July 5) 1969. (OH).

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C. E.

: Osteomalacia with Long-Term Anticonvulsant Therapy in Epilepsy, Brit. Med. J. 4: 69 (Oct. 10) 1970. (CH).

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Deykin

: Current Concepts: Warfarin Therapy (Second of Two Parts), New Engl. J. Med. 283: 801 (Oct. 8) 1970. (R).

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: Anticonvulsant-Associated Megaloblastic Anemia, New Engl. J. Med. 267: 483 (Sept. 6) 1962. (CH).

23.

Elking

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Sr. Kabat

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: Drug Induced Modifications of Laboratory Test Values, Amer. J. Hosp. Pharm. 25: 485 (Sept.) 1968. (R).

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: Methylphenidate Interaction with Both Anticonvulsants and Ethyl Biscoumacetate, J. Am. Med. Assoc. 207: 2053 (Mar. 17) 1969. (CHO).

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Dayton

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: Disappearance of Phenobarbital and Diphenylhydantoin From Serum of Children, Clin. Pharmacol. Therap. 11: 674 (Sept.-Oct.) 1970. (OH).

26.

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Gilman

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28.

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: Carbamazepine-Induced Acceleration of Diphenylhydantoin and Warfarin Metabolism in Man, Clin. Pharmacol. Therap. 12: 539 (May-June) 1971. (OH).

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: Drug Interactions, Lea Febiger, Phila., 1971. (R).

30.

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: Protection from Digitalis Toxicity with the Prophylactic Use of Diphenylhydantoin Sodium; An Arrhythmic-Inotropic Dissociation, Circulation 36: 119–124 (July) 1967. (OA).

31.

Hoffbrand

A. V.

Necheles

T. F.

: Mechanism of Folate Deficiency in Patients Receiving Phenytoin, Lancet 2: 528 (Sept. 7) 1968. (OHT).

32.

Hunter

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33.

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: Studies on Deficiency and Absorption of Folates in Patients on Anticonvulsant Drugs, Australasian Ann. Med. 16: 144 (May) 1967.

34.

Jubiz

: Effect of Diphenylhydantoin on Metabolism of Dexamethasone, New Engl. J. Med. 283: 11 (July 2) 1970. (OHA).

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Karlin

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Kutt

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36.

Kater

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37.

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: Increased Rate of Clearance of Drugs from the Circulation of Alcoholics, Am. J. Med. Sci. 258: 35 (July) 1969. (OH).

38.

Kazamatsuri

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39.

King

T. M.

Burgard

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: Drug Interactions. Am. J. Obstet. Gynecol. 98: 128 (May 1) 1967. (R).

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41.

Kristensen

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42.

Krondl

: Present Understanding of the Interaction of Drugs and Food During Absorption, Can. Med. Assoc. J. 103: 360 (Aug. 15, 29) 1970. (R).

43.

Kupfer

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: The Effect of o.p'-DDD on Cortisol and Hexobarbital Metabolism, Biochem. Pharmacol. 15: 573 (May) 1966.

44.

Kutt

: Diphenylhydantoin Metabolism, Blood Levels, and Toxicity, Arch. Neurol. 11: 642 (Dec.) 1964. (OH).

45.

Kutt

: Depression of Parahydroxylation of Diphenylhydantoin by Antituberculosis Chemotherapy, Neuro. 16: 594 (June) 1966. (OH).

46.

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McDowell

: Management of Epilepsy with Diphenylhydantoin Sodium, J. Am. Med. Assoc. 203: 969 (Mar. 11) 1968. (Report).

47.

Kutt

: Inhibition of Diphenylhydantoin Metabolism in Rats and In Rat Liver Microsomes by Anti-tubercular Drugs, Neurol. 18: 706 (July) 1968. (OA).

48.

Kutt

: The Effect of Phenobarbital on Plasma Diphenylhydantoin Level and Metabolism in Man and in Rat Liver Microsomes, Neurol. 19: 611 (June) 1969. (OHT).

49.

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Verebely

: Metabolism of Diphenylhydantoin by Rat Liver Microsomes, 1. Characteristics of the Reaction, Biochem. Pharmacol. 19: 675 (Mar.) 1970.

50.

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: Diphenylhydantoin Intoxication. A Complication of Isoniazid Therapy, Amer. Rev. Resp. Dis. 101: 377 (Mar.) 1970. (OHAT).

51.

Landy

P. J.

: “Dilantin” Overdosage, Med. J. Aust. 2: 639 (Oct. 12) 1968. (Corresp.).

52.

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E. W.

: Studies on the Metabolism of Diphenylhydantoin (Dilantin), Neurol. 11: 424, 1967. (OH).

53.

Lunde

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: Plasma Protein Binding of Diphenylhydantoin in Man, Clin. Pharmacol. Therap. 11: 846 (Nov.-Dec.) 1970. (OTH).

54.

Meynell

M. J.

: Megaloblastic Anemia in Anticonvulsant Therapy, Lancet 1: 487 (Feb. 26) 1966. (Letter — Comment).

55.

Millichap

J. G.

: Hyperglycemia Effect of Diphenylhydantoin, New Engl. J. Med. 281: 447 (Aug. 21) 1969. (R).

56.

Neubauer

: Mental Deterioration in Epilepsy to Folate Deficiency, Brit. Med. J. 2: 759 (June 27) 1970. (OH).

57.

Olesen

O. V.

: Disulfiram (Antabuse) as Inhibitor of Phenytoin Metabolism, Acta. Pharmacol. 24: 317–322, 1966.

58.

Olesen

O. V.

: The Influence of Disulfiram and Calcium Carbimide on the Serum Diphenylhydantoin. Excretion of HPPH in the Urine, Arch. Neurol. 16: 642–644 (June) 1967. (OH).

59.

Olesen

O. V.

Jensen

O. N.

: Influence of Folic Acid on Phenytoin (DPH) Metabolism and the 24-Hour Fluctuation in Urinary Output of 5-(p-hydroxyphenyl)-5-phenylhydantoin (HPPH), Acta. Pharmacol. Toxicol. 28: 265 (4) 1970. (OH).

60.

Osuntokun

B. O.

: Anticonvulsant Therapy, Folic Acid Deficiency, and Neuropsychiatric Disorders, Brit. Med. J. 2: 636 (June 7) 1969. (CH) (Corres.).

61.

Peters

B. H.

Samaan

N. A.

: Hyperglycemia with Diminished Insulinogenesis in Diphenylhydantoin Toxicity, Diabetes 18 (Suppl. 1): 368, 1969. (CH) (Abstract).

62.

Peters

B. H.

Samaan

N. A.

: Hyperglycemia with Relative Hypoinsulinemia in Diphenylhydantoin Toxicity, New Engl. J. Med. 281: 91 (July 10) 1969. (CH).

63.

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A. J.

: Effects of Folic Acid on Fit Frequency and Behavior in Epileptics on Anticonvulsants, Lancet 1: 867 (Apr. 25) 1970. (OH).

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M. J.

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67.

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E. H.

: Effects of Folic Acid on the Mental State and Fit Frequency of Drug-Treated Epileptic Patients, Lancet 1: 1086 (May 20) 1967. (OH).

68.

Richens

Rowe

D. J. F.

: Disturbance of Calcium Metabolism by Anticonvulsant Drugs, Brit. Med. J. 4: 73 (Oct. 10) 1970. (OH).

69.

Rosenberg

I. H.

Streiff

R. R.

: Intestinal Folic Acid Conjugase, Gastroenterology 52: 1117 (June) 1967. (Abstract).

70.

Rosenberg

I. H.

: Impairment of Intestinal De-conjugation of Dietary Folate, Lancet 2: 530 (Sept. 7) 1968. (OHT).

71.

Rothermich

N. O.

: Diphenylhydantoin Intoxication, Lancet 2: 640 (Sept.) 1966. (Letters) (CH).

72.

Solomon

H. M.

Schrogie

J. J.

: The Effect of Phenyramidol on the Metabolism of Diphenylhydantoin, Clin. Pharmacol. Therap. 8: 554 (July-Aug.) 1967. (OH).

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R. R.

Rosenberg

I. H.

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74.

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Buchthal

: Diphenylhydantoin and Phenobarbital, Am. J. Dis. Child 108: 82 (July) 1964. (OH).

75.

Taylor

C. R.

: Phenytoin Intoxication, Brit. Med. J. 1: 48 (Jan. 3) 1970. (R).

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Tisman

: Dilantin and Folic Acid Deficiency, Ann. Internal Med. 70: 233 (Jan.) 1969. (Letter — Comment).

77.

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J. H.

: Outbreak of Anticonvulsant Intoxication in an Australian City, Brit. Med. J. 4: 271 (Oct. 31) 1970. (OH).

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F. J. E.

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79.

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N. M. A.

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E. E.

Jr. : Effect of Diphenylhydantoin on Cortisol Metabolism in Man, J. Clin. Invest. 43: 1824 (Sept.) 1964. (OH).

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Werk

E. E.

: Interference in the Effect of Dexamethasone by Diphenylhydantoin, New Engl. J. Med. 281: 32 (July 3) 1969. (OH).

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E. E.

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Drug Interactions Central Nervous System Drugs: Anticonvulsants

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