Buccal absorption of 31 aromatic and aliphatic acids and 10 basic drugs in human subjects has been found to be parabolically dependent on the log P, where P is the l-octanol-water partition coefficient. The ideal lipophilic character (log Po) for maximum buccal absorption is found to range from 4.2 to 5.5. The log of the permeability constant of a series of alcohols and steroids has been found to be linearly dependent upon the log of the partition coefficient measured in three different solvent systems.
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