Pharmacokinetics: 10. Introduction to Compartment Models

Teorell T. : Kinetics of Distribution of Substances Administered to the Body I. The Extravascular Modes of Administration, Arch. Intern. Pharmacodyn. 57: 205–225, 1937.

Teorell T. : Kinetics of Distribution of Substances Administered to the Body II. The Intravascular Modes of Administration, Arch. Intern. Pharmacodyn. 57: 226–240, 1937.

Widmark E. , and Tandberg J. : Uber die Bedingungen für die Akkumulation indifferenter Narkotika. Theoretische Berechwingen, Biochem. Z. 147: 358–369, 1924.

Wagner J. G. : Pharmacokinetics, Ann. Rev. Pharmacol. 8: 67–94, 1968 (a).

Wagner J. G. : Pharmacokinetics 1. Definitions, Modeling and Reasons for Measuring Blood Levels and Urinary Excretion, Drug Intelligence 2: 38–42, 1968 (b).

Berman M. , and Schoenfeld R. : Invariants in Experimental Data on Linear Kinetics and the Formulation of Models, J. Appl. Physics 27: 1361–1370, 1956.

Hazelrig Jane B. : The Impact of High-Speed Automated Computation on Mathematical Models, Proc. Mayo Clinic 39: 841–848, 1964.

Wagner J. G. , Northam J. I. , Alway C. D. , and Carpenter O. S. : Blood Levels of Drug at the Equilibrium State After Multiple Dosing, Nature 207: 1301–1302, 1965.

Wagner J. G. : Drug Accumulation, J. Clin. Pharmacol. J. New Drugs 7: 84–88, 1967.

Northam J. I. , and Wagner J. G. : “Prediction of Numbers of Doses to Reach Equilibrium State,” presented Basic Pharmaceutics Section, A.Ph.A. Academy of Pharmaceutical Sciences, Miami Beach, Florida, May 5–10, 1968.

Van Rossum J. M. , and Tomey A. H. M. : Rate of Accumulation and Plateau Plasma Concentration of Drugs After Chronic Administration, J. Pharm. Pharmacol. 20: 390–392, 1968 (a).

Van Rossum J. M. : Pharmacokinetics of Accumulation, J. Pharm. Sci. 57: 2162–2165, 1968 (b).

Boxer G. E. , Jelinek V. C. , Tompsett R. , DuBois R. , and Edison A. O. : Streptomycin in Blood: Chemical Determinations After Single and Repeated Intramuscular Injections, J. Pharm. Exptl. Therap. 92: 226–235, 1948.

Swintosky J. V. : Illustrations and Pharmaceutical Interpretations of First Order Drug Elimination Rate from the Bloodstream, J. Am. Pharm. Assoc. Sci. Ed. 45: 395–400, 1956.

Swintosky J. V. , Bondi A. Jr. , and Robinson M. J. : Sulfaethylthiadiazole IV. Steady State Blood Concentrations and Urinary Excretion Data Following Repeated Oral Doses, J. Am. Pharm. Assoc. Set. Ed. 47: 753–756, 1958.

Von Wittenau M. S. , and Yeary R. : The Excretion and Distribution in Body Fluids of Tetracyclines After Intravenous Administration to Dogs, J. Pharmacol Exptl. Therap. 140: 258–266, 1963.

Smith D. L. , Wagner J. G. , and Gerritsen G. C. : Absorption, Metabolism, and Excretion of 5–Methylpyrazole-3–Carboxylic Acid in the Rat, Dog and Human, J. Pharm. Sci. 56: 1150–1157, 1967.

Wagner J. G. : Pharmacokinetics 8. Construction of Percent Absorbed-Time Plots Based on the Two Compartment Open Model, Drug Intelligence 3: 82–97 (Mar.) 1969.

Dayton D. G. , Cucinell S. A. , Weiss M. , and Perel J. M. : Dose Dependence of Drug Plasma Level Decline in Dogs, J. Pharmacol. Exptl. Therap. 158: 305–316, 1967.

Wagner J. G. : Pharmacokinetics 3. Half-Life and Volume of Distribution, Drug Intelligence 2: 126–133, 1968 (c).

Hammer W. M. , and Brodie B. B. : Application of Isotope Derivative Technique to Assay of Secondary Amines: Estimation of Desipramine by Acetylation with H³-Acetic Anhydride, J. Pharmacol. Exptl. Therap. 157: 503–508, 1967.

Krüger-Thiemer E. : Funktionale Beziehungen Zwischen Den Pharmacokokinetischen Eigenschaften und der Dosierung Von Chemotherapeutica, Klin-Wochenscrift 38: 514–520, 1960.

Krüger-Thiemer E. : “Cause and Prevention of Drug Accumulation,” paper presented to the Scientific Section of the American Pharmaceutical Association, Las Vegas, Nevada, March 26–29, 1962.