Abstract
This paper describes the in vitro diffusion, through the cuprophane membrane, of a significant number of drugs currently being administered to patients who are undergoing hemodialysis.
The diffusion potentials of the drug molecules through the cuprophane membrane, the dialyzing membrane which separates the blood and the dialysate during the dialysis exchange must be accurately determined to establish the relationship between dosage administration and the quantities of the drug remaining in the patient during the dialysis procedure and in the immediate postdialysis period.
The results of this study will provide the prescribing physician with the information that will be useful in selecting the proper therapeutic agent and the dosage needed to assure adequate blood levels while the patient is undergoing hemodialysis.
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