Drug Interactions III. Classes of Drugs and Their Interactions Anti-Infective Agents

American Hospital Formulary Service, American Society of Hospital Pharmacists, Washington, D.C. (R)

Anon.: Drug Interactions That Can Affect Your Patients, Patient Care 1: 32 (Nov.) 1967. (R)

Anon.: The Choice of Systemic Antimicrobial Drugs, Med. Letter 10: 17 (Oct. 4) 1968. (R)

Anon.: Cephalothin and Clinitest Test, Clin-Alert No. 170, June 28, 1966. (R)

Anon.: Effect of pH of the Urine on Antimicrobial Therapy of Urinary Tract Infections, Med. Letter 9: 47 (June 16) 1967. (R)

Anon.: Quinidine Potentiates Muscle Relaxants, Clin-Alert No. 291, Dec. 8, 1967, (OA)

Anon.: Penicillin Increases 17–Hydroxycorticosteroids and 17–Ketosteroids, Clin-Alert No. 215, Sept. 27, 1967. (R)

Avakian S. , and Kabacoff B. L. : Enhancement of Blood Antibiotic Levels Through the Combined Oral Administration of Phenethicillin and Chymotrypsin, Clin. Pharmacol. Therap. 5: 716 (Nov.–Dec.) 1964. (OH)

Barber M. : Drug Combination in Antibacterial Chemotherapy, Proc. Roy. Soc. Med. 58: 990 (Nov.) 1965. (R)

Becker K. L. , Katz S. , and Miale A. Jr. : Tetracycline and Thyroid Function, J. Am. Med. Assoc. 199: 416 (Feb. 6) 1967. (OH)

Belam O. H. : Anaesthesia and Therapeutic Drugs, Postgrad. Med. J. 42: 374 (June) 1966. (R)

Bell R. W. , and Jenicek J. A. : Respiratory Failure Following Intramural Bowel Injection of Neomycin, Report of a Case, Med. Ann. D. C. 35: 603 (Nov.) 1966. (CH)

Blake-Knox P. E. A. : Neuromuscular Block with Streptomycin, Brit. Med. J. 1: 1319, 1961. (CH)

Block L. H. , and Lamy P. P. : Legend Drugs with O-T-C Drugs in Therapeutic Incompatibilities, J. Am. Pharm. Assoc. NS8: 66 (Feb.) 1968. (R)

Bower B. F. , McComb R. , and Ruderman M. : Effect of Penicillin on Urinary 17–Ketogenic and 17–Ketosteroid Excretion, New Engl. J. Med. 277: 530 (Sept. 7) 1967. (OH)

Bristol Kanamycin Sulfate Injection, Bristol Laboratories Product Brochure, October, 1967. (R)

Burns J. J. , and Conney A. H. : Enzyme Stimulation and Inhibition in the Metabolism of Drugs, Proc. Roy. Soc. Med. 58: 955 (Nov.) 1965. (R)

Busfield D. , Child K. J. , and Tomich E. G. : An Effect of Phenobarbitone on Griseofulvin Metabolism in the Rat, Brit. J. Pharmacol. 22: 137 (Feb.) 1964. (OA, T)

Bush G. G. : Prolonged Neuromuscular Block Due to Intraperitoneal Streptomycin, Brit. Med. J. 1: 557, (Feb. 25) 1961. (CH)

Catalano P. M. , and Cullen S. I. : Warfarin Antagonism by Griseofulvin, Clin. Res. 14: 266 (Apr.) 1966. (CH)

Chang T. W. , and Weinstein L. : Inhibitory Effects of Other Antibiotics on Bacterial Morphologic Changes Induced by Penicillin G, Nature (Lond) 211: 763 (Aug. 13) 1966. (OT)

Cocke J. G. Jr. : Chloramphenicol Optic Neuritis, Am. J. Diseases Children 114: 424 (Oct.) 1967. (CH)

Cross F. C. , Canada A. T. Jr. , and Davis N. M. : The Effect of Certain Drugs on the Results of Some Common Laboratory Diagnostic Procedures, Am. J. Hosp. Pharm. 23: 235 (May) 1966. (R)

Crounse R. G. : Effective Use of Griseofulvin, Arch. Dermatol. 87: 176 (Feb.) 1963. (R)

Cullen S. I. , and Catalano P. M. : Griseofulvin-Warfarin Antagonism, J. Am. Med. Assoc. 199: 582 (Feb. 20) 1967. (CH)

Done A. K. : Developmental Pharmacology, Clin. Pharmacol. Therap. 5: 432 (July–Aug.) 1964. (R)

Doremus W. P. : Respiratory Arrest Following Intra-peritoneal Use of Neomycin, Ann. Surg. 149: 546 (Apr.) 1959. (CH)

Eagle H. , and Fleischman R. : Therapeutic Activity of Bacitracin in Rabbit Syphilis, and Its Synergistic Action with Penicillin, Proc. Soc. Exptl. Biol. Med. 68: 415, 1948. (OA)

Elking M. P. Sr. , and Kabat H. F. : Drug Induced Modifications of Laboratory Test Values, Am. J. Hosp. Pharm. 25: 485 (Sept.) 1968. (R)

Engel H. L. , and Denson J. S. : Respiratory Depression Due to Neomycin, Surgery 42: 862 (Nov.) 1957. (CH)

Ficarra B. J. : Tetracycline and Thyroid Function, J. Am. Med. Assoc. 200: 348 (Apr. 24) 1967. (R)

Fisk G. C. : Respiratory Paralysis After a Large Dose of Streptomycin, Brit. Med. J. 1: 556, 1961. (CH)

Foldes F. F. , Lunn J. N. , and Benz H. G. : Prolonged Respiratory Depression Caused by Drug Combinations. Muscle Relaxants and Intraperitoneal Antibiotics as Etiologic Agents, J Am. Med. Assoc. 183: 672 (Feb. 23) 1963. (CH)

Freemon F. R. , Parker R. L. Jr. , and Greer M. : Unusual Neurotoxicity of Kanamycin, ibid. 200: 410 (May 1) 1967. (CH)

Gibaldi M. , and Schwartz M. A. : Apparent Effect of Probenecid on the Distribution of Penicillins in Man, Clin. Pharmacol. Therap. 9: 345 (May–June) 1968. (OH)

Goodman L. S. , and Gilman A. : The Pharmacolog-ical Basis of Therapeutics, Third Ed., New York, 1965, Macmillan Co., p. 607.

Ibid., p. 1172.

Ibid., p. 1176.

Ibid., p. 1180.

Ibid., p. 1181.

Ibid., p. 1183.

Ibid., p. 1245.

Ibid., p. 1265.

Ibid., p. 1277.

Gralnick H. R. , Wright L. D. Jr. , and McGinniss M. H. : , Coomb's Positive Reactions Associated with Sodium Cephalothin Therapy, J. Am. Med. Assoc. 199: 725 (Mar. 6) 1967. (CH)

Hewitt W. L. , Seligman S. J. , and Deigh R. A. : Kinetics of the Synergism of Penicillin-Streptomycin and Penicillin-Kanamycin for Enterococci and Its Relationship to L-Phase Variants, J. Lab. Clin. Med. 67: 792 (May) 1966. (OT)

Hinninghake D. B. , and Azarnoff D. L. : Drug Interactions with Warfarin, Arch. Internal Med. 121: 349 (Apr.) 1968. (R)

Hussar D. A. : Therapeutic Incompatibilities: Drug Interactions, Hosp. Pharmacy 3: 14 (Aug.) 1968. (R)

Jawetz E. , Gunnison J. B. , and Coleman V. R. : The Combined Action of Penicillin with Streptomycin or Chloromycetin on Enterococci in vitro, Science 111: 254 (Mar. 10) 1950. (OT)

Kaplan D. , and Koch W. : Synergistic Effect of Combinations of Cephalothin and Kanamycin on Strains of E. coli, Nature 218: 1165 (June 22) 1968. (OT)

Krauer-Meyer B. : Uber die Ursachen von Vitamin-K-Mangel-Zustanden. Theorie und Klinik (Vitamin K De-ficiency Following Antibiotic Therapy), Schweiz. Med. Wschr. 96/52: 1746 (Dec. 31) 1966. (CH)

Kunin C. M. , Jones W. F. Jr. , and Finland M. ; Enhancement of Tetracycline Blood Levels, New Engl. J. Med. 259: 147 (July 24) 1957.

Kunin C. M. , and Finland M. : Clinical Pharmacology of the Tetracycline Antibiotics, Clin. Pharmacol. Therap. 2: 51 (Jan.–Feb.) 1961. (R)

Kunin C. M. : Enhancement of Antimicrobial Activity of Penicillins and Other Antibiotics in Human Serum by Competitive Serum Binding Inhibitors, Proc. Soc. Exptl. Biol. Med. 117: 69 (Oct.) 1964. (OT)

Kunin C. M. : Clinical Pharmacology of the New Penicillins. II. Effect of Drug Which Interfere with Binding to Serum Proteins, Clin. Pharmacol. Therap. 7: 180 (Mar.–Apr.) 1966. (OHT)

Lepper M. H. , and Dowling H. F. : Treatment of Pneumococci Meningitis with Penicillin Compared with Penicillin plus Aureomycin, Arch. Internal Med. 88: 489 (Oct.) 1951. (OH)

Loder R. E. , and Walker G. F. : Neuromuscular-Blocking Action of Streptomycin, Lancet 1: 812, 1959. (C)

Lorenc E. : A New Factor in Griseofulvin Treatment Failures: Case Report, Missouri Med. 64: 32 (Jan.) 1967. (C)

Mattila M. J. , and Tiitinen H. : Serum Levels and Urinary Excretion of Ethionamide and Isoniazid after an Oral Intake of Chymotrypsin, Farm. Aikakauslehti 76: 294 (Nov.–Dec.) 1967. (OH)

McCance R. A. : Renal Physiology in Infancy, Am. J. Med. 9: 229 (Aug.) 1950. (R)

McGinniss M. H. , Wright L. D. , and Gralnick H. R. : Coombs Positivity and Keflin Therapy, Transfusion 6/5: 516 (Sept.–Oct.) 1966. (C)

Middleton W. H. , Morgan D. C. , and Moyers J. : Neostigmine Therapy for Apnea Occurring after Administration of Neomycin, J. Am. Med. Assoc. 165: 2186 (Dec. 28) 1957. (C)

Miller J. B. : Hypoglycaemic Effect of Oxytetracycline, Brit. Med. J. 2: 1007 (Oct. 22) 1966. (C)

Modell W. : Drugs of Choice 1966–1967, C. V. Mosby Co., St. Louis. (R)

Molthan L. : Cephalothin and Positive Direct Coombs Test, Transfusion 6: 517 (Sept.–Oct.) 1966.

Molthan L. , Reidenberg M. M. , and Eichman M. F. : Postive Direct Coombs Tests Due to Cephalothin, New Eng. J. Med. 277: 123 (July 20) 1967. (C)

Neill Carre , McCory , and Thompson : A Possible Source of Error in the Diagnosis of Pheochromocytoma, J. Clin. Pathol. 14: 415 (July) 1961. (O)

Numeroff M. , and Slater S. : Falsely Elevated Values for Urinary 17–Ketosteroids and 17–Hydroxycorticoids Associated with Ingestion of Triacetyloleandomycin, J. Clin. Endocrinol. Metab. 19: 1350 (Oct.) 1959. (C)

Parisi A. F. , and Kaplan M. H. : Apnea During Treatment with Sodium Colistimethate, J. Am. Med. Assoc. 194: 298 (Oct. 18) 1965. (C)

Poth E. J. : Critical Analysis of Intestinal Antisepsis, ibid. 163: 1317 (Apr. 13) 1957. (C)

Preti M. , and Delia Bella D. : Influence of Certain Drugs on the Acute Toxicity of Specific Antibiotics, Boll. Chim. Farm. 106: 603 (Sept.) 1967. (OAT)

Pridgen J. E. : Respiratory Arrest Thought to be Due to Intraperitoneal Neomycin, Surgery 40: 571 (Sept.) 1956. (C)

Sabath L. D. , Elder H. A. , McCall C. E. , and Finland M. : Synergistic Combinations of Penicillins in the Treatment of Bacteriuria, New Engl. J. Med. 277: 232 (Aug. 3) 1967. (OH)

Sabawala P. B. , and Dillon J. B. : The Action of Some Antibiotics on the Human Intercostal Nerve-Muscle Complex, Anesthesiology 20: 659 (Sept.–Oct.) 1959. (OT)

Searle G. D. & Co., Dramamine Package Brochure, April 22, 1966. (R)

Sikh S. S. , and Sachdev K. S. : Duration of the Neuromuscular Blocking Action of Streptomycin, Brit. J. Anaesth. 37: 158 (Mar.) 1965. (OA)

Simon C. : Problem of Antagonism with Antibiotic Combinations, Chemotherapia 11: 43, 1966. (G) (OT)

Stuart D. M. : Drug Metabolism, Part II, Drug Interactions, PharmIndex 10: 4 (Oct., Sec. 1) 1968. (R)

Trubuhovich R. V. : Delayed Reversal of Diallylnortoxiferine after Streptomycin, Brit. J. Anaesth. 38: 843 (Oct.) 1966. (C)

Way W. L. , Katzung B. G. , and Larson C. P. Jr. : Recurarization with Quinidine, J. Am. Med. Assoc. 200: 153 (Apr. 10) 1967. (C)

Anon.: Antibiotic Combinations, Lancet 1: 863 (Apr. 16) 1966.

Brienza A. : Prolungamento del Blocco Neuromusculare du Curarizz Anti per Azione di Antibiotics, Rass. Int. Clin. Ter. 46/20: 1081, 1966.

Bychkov S. M. : Interaction of Heparin with Polymyxin M and Streptomycin, Vopr. Med. Khim. 12: 397, 1966. (IPA 4: 429 (Apr. 30) 1967)

Daikos G. K. , Kontomichalou P. , and Karakitsou A. : Clinico-Laboratory Experience with Ampicillin, Chemotherapia 9: 35, 1964.

Holt R. : The Bacterial Degradation of Chloramphenicol, Lancet 1: 1259 (June 10) 1967.

Idriss M. : Study on the Combined Effect of Neomycin and Ampicillin on Salmonellae, Path. Microbiol. 28: 130, 1965.

Jurjer J. N. , Kiryakina G. K. , and Jrkou A. D. : A Prolonged Apnea Induced by the Use of Large Doses of Antibiotics in Operative Regional Perfusion of the Extremity, Vestn. Khir. Grekor 98/3: 130, 1967.

Kaplan D. , and Koch W. : Synergism of Three Antimicrobial Drugs, Nature 209: 718 (Feb. 12) 1966.

Khashim M. A. , and Kharitonova A. M. : A Study on the Functional State of the Thyroid Gland After Prolonged Use of Penicillin and Streptomycin, Antibiotiki 12/1: 39, 1967.

LaMarra C. : Blocco Neuromuscolare Post-Operatonio da Streptomicina, Anest. Rianim. 7/1: 93, 1966.

Manten A. , and Terra J. I. : The Antagonism Between Penicillin and Other Antibiotics in Relation to Drug Concentration, Chemotherapia 8: 21, 1964.

Mayer G. , and Schwabe H. K. : Die Beeinflussung des Cortisonabbaues der Rattinieber durch Streptomycin-sulfat, Arzneimittel-Forsch. 16: 1317, 1966.

Moulten R. P. , and Koelman A. : Interaction Patterns of Combined Antibacterial Agents, Chemotherapia 11: 10, 1966.

Pinkerton H. H. , and Munro J. R. : Respiratory Insufficiency Associated with the Use of Streptomycin, Scot. Med. J. 9: 256 (June) 1964.

Seneca H. , and Peer P. : Enhancement of Blood and Urine Tetracycline Levels with a Chymotrypsin-Tetracycline Preparation, J. Am. Geriat. Soc. 13: 708 (Aug.) 1965.

Seneca H. , and Peer P. : Effect of Chymotrypsin on the Absorption of Tetracycline from the Intestinal Tract, Antimicrob. Agents Chemotherap. 3: 657, 1963.

Simon C. , and Bontemps M. (Is there any Likelihood of Antagonism when Antibiotic Combinations are Used in Clinical Practice) (Ger) Ann. Paediat. 207: 53, 1966.

Viljocn J. F. , Parenteral Neomycin and Muscle Relaxants. Two Case Reports of Interest, So. Afr. Med. J. 40/3: 963, 1966.

Wullen F. , Kast G. , and Bruck A. : Side Effects of Tetracycline Administration to Inpatients with Myasthenia Gravis, Deut. Med. Wochschr. 92: 667 (Apr. 7) 1967.