Pharmacokinetics: 6. Types of Data,Derived Parameters and Analyses. Absorption Models

Northam J. I. , and Wagner J. G. : “Computer Analysis and Print-Out of Crossover Studies Where Blood Level and/or Urinary Excretion Data Are Collected,” presented at the Second Annual Meeting of the American College of Clinical Pharmacology and Chemotherapy, Knickerbocker Hotel, Chicago, Ill., November 3–4, 1965.

Wagner J. G. : Design and Data Analysis of Biopharmaceutical Studies in Man, Can. J. Pharm. Sci. 1: 55–68, 1966.

Cole J. W. L. , and Grizzle J. E. : Applications of Multivariate Analysis of Variance to Repeated Measurements Experiments, Biometrics 22: 810–828, 1966.

Danford M. D. , Hughes H. M. , and McNee R. C. : On the Analysis of Repeated Measurements Experiments, Biometrics 16: 347–365, 1960.

Church A. : Analysis of Data When the Response Is a Curve, Technometrics 8: 229–246, 1966.

Redman C. E. : “Biological Applications of Principal Components,” presented at the Am. State Assoc. Annual Meeting, Washington, D.C., December 27–30, 1967.

Wagner J. G. , Gerard E. S. , and Kaiser D. G. : The Effect of the Dosage Form on Serum Levels of Indoxole, Clin. Pharmacol. Therap. 7: 610–619, 1966.

Wagner J. G. : Use of Computers in Pharmacokinetics, Clin. Pharmacol. Therap. 8: 201–218, 1967.

Wagner J. G. , Novak E. , Leslie L. G. , and Metzler C B. : Absorption, Distribution and Elimination of Spectinomycin Dihydrochloride in Man, Intern. J. Clin. Pharmacol., 1: 261–285, 1968, Part 4.

Nelson E. : Kinetics of Drug Absorption, Distribution, Metabolism and Excretion, J. Pharm. Sci. 50: 181–192, 1961.

Wagner J. G. , and Northam J. I. : Estimation of Volume of Distribution and Half-Life of a Compound after Rapid Intravenous Injection, J. Pharm. Sci. 56: 529–531, 1967.

Riegelman S. , Loo J. , and Rowland M. : Concepts of Volume of Distribution and Possible Errors in Evaluation of This Parameter, J. Pharm. Sci. 57: 128–133, 1968.

Wagner J. G. , and Metzler C. M. : Prediction of Blood Levels after Multiple Dose from Single Dose Blood Level Data. Data Generated with the Two Compartment Open Model Analyzed According to the One Compartment Open Model, submitted to J. Pharm. Sci., 1968.

Loo J. C. K. , and Riegelman S. : “A New Method for Calculating the Intrinsic Absorption Rate of Drugs,” presented to the APhA Academy of Pharmaceutical Sciences, Las Vegas, April 1967

Wagner J. G. : Pharmacokinetics, Ann. Rev. Pharmacol. 8: 67–94, 1968.

Kedem O. , and Katchalsky A. : Thermodynamic Analysis of the Permeability of Biological Membranes to Non-Electrolytes, Biochim. Biophys. Acta 27: 229–246, 1958.

Fordtran J. S. , Rector F. C. Jr. , Ewton M. F. , Suter N. , and Kinney J. : Permeability Characteristics of the Human Small Intestine, J. Clin. Invest. 44: 1935–1944, 1965.

Lifson N. , and Hakim A. A. : Simple Diffusive Convective Model for Intestinal Absorption of a Nonelectrolyte (Urea), Am. J. Physiol. 211: 1137–1146, 1966.

Higuchi W. I. : Diffusional Models Useful in Biopharmaceutics, Drug Release Rate Processes, J. Pharm. Sci. 56: 315–324, 1967.

Stehle R. G. , and Higuchi W. I. : Diffusional Model for Transport Rate Studies Across Membranes, J. Pharm. Sci. 56: 1367–1368, 1967.

Niebergall P. J. , and Sugita E. C. : Mathematics of Three-Phase in vitro Absorption Models, J. Pharm. Pharmacol. 19: 847–850, 1967.