Abstract
The products and kinetics of hydrolysis of the nerve gas antidote bis(4-hydroxyiminomethyl - 1 - pyridinemethyl) ether dichloride (Toxogonin ®) have been investigated. A survey of these studies is given:
The hydrolytic reactions were studied in the pH range 1 M hydrochloric acid to 1 M sodium hydroxide at 25, 45, 75 and 85° C.
Rate constants were determined in dilute aqueous solution, generally with an initial Toxogonin concentration of 0.01 mg per ml.
In addition, a report is given concerning two-year storage of 25 percent (w/v) Toxogonin solutions at pH 2.5, 3.0 and 3.5. The solutions were stored in glass or polypropylene ampuls at 5, 15, 25 and 45°C. At 5 and 15C° decomposition was negligible, at 25 and 45 °C average decomposition was 1.5 percent and 3.3 percent, respectively.
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