Methods for detection of particulate matter in parenteral solutions are inadequate at the present time. The potential hazard of injecting particulate matter into the circulation of seriously ill patients cannot be overemphasized. The need for more research into this question is clear, and we have briefly outlined our future objectives in this activity.
Get full access to this article
View all access options for this article.
References
1.
FeldmannE. G.: Introductory Comments to Discussion, Proceedings, F.D.A. Symposium on Safety of Large Volume Parenteral Solutions, Washington, D. C, July 28-29 1966.
2.
GarvanJ. M., and GunnerB. W.: Intravenous Fluids, Med. J. Australia2: 140–145 (July 27) 1963.
3.
GarvanJ. M., and GunnerB. W.: The Harmful Effects of Particles in Intravenous Solutions, ibid.2: 1–6 (July 4) 1964.
4.
YakowitzM. L.: Problems Associated with the Manufacture, Storage and Use of Large Volume Parenteral Solutions, Proceedings, F.D.A. Symposium on Safety of Large Volume Parenteral Solutions, Washington, D. C., July 28-29, 1966.
5.
LachmanL.: Contributions of Rubber Closures to Particulate Matter in Large Volume Parenteral Solutionsibid.1966.
6.
GrovesM. J., and MajorJ. F.: Assessment of Particulate Matter in Normal Saline for Injection B. P. by Means of the Coulter Counter, Pharm. J.193: 227–228 (Sept. 12) 1964.
7.
VesseyI., and KendallC. E.: Determination of Particulate Matter in Intravenous Solutions, Analyst91: 273–279 (April) 1966.
8.
GrovesM. J.: Some Size Distributions of Particulate Contamination Found in Commercially Available Intravenous Solutions, J. Pharm. Pharmacol.18: 161–167 (March) 1966.
9.
LockhartJ. D.: Medical Significance of Particulate Matter in Large Volume Parenteral Solutions, Proceedings, F. D. A. Symposium on Safety of Large Volume Parenteral Solutions, Washington, D. C, July 28-29, 1966.
10.
GrossM. A.: Danger of Particulate Matter in Solutions for Intravenous Use, ibid.
11.
HardawayR. M.III: Syndrome of Disseminated Intravascular Coagulation, Chapters 6 and 29, Charles C. Thomas, Springfield, Ill., 1966.
12.
HudsonH. E.: A Method of Measuring Matter Suspended in Liquids, Pharm. J.186: 201–203 (March 11) 1966.
13.
HoN. F. H., and HiguchiW. I.: Kinetics of Aggregation of Denatured Protein I. Methodology Based on the Multichannel Particle Counter and Analyzer, J. Pharm. Sci.56: In Press.