Reply: Crushed Posaconazole Delayed-Release Tablets Via Enteral Feeding Tubes: A Cautionary Tale

Kane N Rikard R McCrory K Marx AH . Crushed posaconazole delayed-release tablets via enteral feeding tubes: a cautionary tale [published online ahead of print April 30, 2024]. Ann Pharmacother. doi:10.1177/10600280241249705

Noxafil (posaconazole) [package insert]. Merck & Co, Inc; 2022.

Mason MJ McDaneld PM Musick WL Kontoyiannis DP. Serum levels of crushed posaconazole delayed-release tablets. Antimicrob Agents Chemother. 2019;63(5):e02688-18. doi:10.1128/AAC.02688-18

Dieringer TD Schaenman JM Davis MR. Enteral feeding tube administration with therapeutic drug monitoring of crushed posaconazole tablets and opened isavuconazonium sulfate capsules. J Antimicrob Chemother. 2022;77:1417-1423. doi:10.1093/jac/dkac035

Manesh A Devasagayam E Bhanuprasad K , et al. Efficacy of crushed delayed-release posaconazole tablets in rhino-orbito-cerebral mucormycosis. Antimicrob Agents Chemother. 2022;66:e0108522. doi:10.1128/aac.01085-22

Stevens RW O’Connell C Huang A Epps KL Ilges D. Therapeutic drug monitoring following crushed administration of delayed-release posaconazole tablets via enteral feeding tubes. J Antimicrob Chemother. 2023;78:553-555. doi:10.1093/jac/dkac427