Increased Theophylline Plasma Concentrations in a Patient With Covid-19

Boylan PM Abdalla M Bissell B Malesker MA Santibañez M Smith Z. Theophylline for the management of respiratory disorders in adults in the 21st century: a scoping review from the American College of Clinical Pharmacy Pulmonary Practice and Research Network. Pharmacotherapy. 2023;43(9):963-990. doi:10.1002/phar.2843.

Barnes PJ. Theophylline. Am J Respir Crit Care Med. 2013;188(8):901-906. doi:10.1164/rccm.201302-0388PP.

Evans WE Schentag JJ Jusko WJ , eds. Theophylline. In: Applied pharmacokinetics: principles of therapeutic drug monitoring. 3rd ed. Vancouver, WA: Applied Therapeutics; 1992;17.

White CM Sicignano DJ Smith K. Impact of interferons and biological drug inhibitors of IL-2 and IL-6 on small-molecule drug metabolism through the cytochrome P450 system. Ann Pharmacother. 2022;56(2):170-180. doi:10.1177/10600280211022281.

Morgan ET. Impact of infectious and inflammatory disease on cytochrome P450-mediated drug metabolism and pharmacokinetics. Clin Pharmacol Ther. 2009;85(4):434-438. doi:10.1038/clpt.2008.302.

Deb S Arrighi S. Potential effects of COVID-19 on cytochrome P450-mediated drug metabolism and disposition in infected patients. Eur J Drug Metab Pharmacokinet. 2021;46(2):185-203. doi:10.1007/s13318-020-00668-8.

Lim SYM Al Bishtawi B Lim W. Role of cytochrome P450 2C9 in COVID-19 treatment: current status and future directions. Eur J Drug Metab Pharmacokinet. 2023;48(3):221-240. doi:10.1007/s13318-023-00826-8.

Horn JR Hansten PD Chan LN. Proposal for a new tool to evaluate drug interaction cases. Ann Pharmacother. 2007;41(4):674-680. doi:10.1345/aph.1H423.

UpToDate. Accessed May 31, 2023. https://www.uptodate.com/contents/theophylline-drug-information?search=theophylline&source=panel_search_result&selectedTitle=1~148&usage_type=panel&kp_tab=drug_general&display_rank=1.