Tecovirimat Use in Combination With Fixed-Dose Bictegravir in a Person With HIV and Concurrent Monkeypox

Abstract

Get full access to this article

View all access options for this article.

References

Thornhill

Barkati

Walmsley

, et al. Monkeypox virus infection in humans across 16 countries—April-June 2022. N Engl J Med. 2022;387:679-691. doi:10.1056/NEJMoa2207323

Curran

Eberly

Russell

, et al. HIV and sexually transmitted infections among persons with monkeypox cases—eight US jurisdictions, May 17-July 22, 2022. MMWR Morb Mortal Wkly Rep. 2022;71:1041-1047. doi:10.15585/mmwr.mm7136a1

O’Shea

Filardo

Bamrah Morris

Weiser

Petersen

Brooks

. Interim guidance for prevention and treatment of monkeypox in persons with HIV infection—United States, August 2022. MMWR Morb Mortal Wkly Rep. 2022;71:1023-1028. doi:10.15585/mmwr.mm7132e4

University of Liverpool. HIV drug interactions. Date unknown. Accessed October 24, 2022. https://www.hiv-druginteractions.org/checker

Clinical Guidelines Program. Drug-drug interactions; ARVs and treatments for severe monkeypox. Date unknown. Accessed December 2, 2022. https://www.hivguidelines.org/antiretroviral-therapy/monkeypox/

TPOXX (tecovirimat) [package insert]. Winchester, KY: Catalent Pharma Solutions; 2022.

US Department of Health and Human Services, Food and Drug Administration, Center for Drug Evaluation and Research. Clinical drug interaction studies–cytochrome P450 enzyme- and transporter-mediated drug interactions guidance for industry. Published January 2020. Accessed December 2, 2022. https://www.fda.gov/regulatory-information/search-fda-guidance-documents/clinical-drug-interaction-studies-cytochrome-p450-enzyme-and-transporter-mediated-drug-interactions

Biktary (bictegravir, emtricitabine, tenofovir alafenamide) [package insert]. Foster City, CA: Gilead Sciences, Inc.; 2021.

Eron

Jr Wilkin

Ramgopal

, et al. A daily single-tablet regimen (STR) of bictegravir/emtricitabine/tenofovir alafenamide (B/F/TAF) in virologically-suppressed adults living with HIV and end stage renal disease on chronic hemodialysis. Open Forum Infect Dis. 2020;7:S529-S530.

10.

Tempestilli

D’Avolio

De Nicolo

Agrati

Antinori

Cicalini

. Pharmacokinetics of bictegravir, emtricitabine and tenofovir alafenamide in a gastrectomized patient with HIV. J Antimicrob Chemother. 2021;76:3320-3322. doi:10.1093/jac/dkab319

11.

Paton

Musaazi

Kityo

, et al. Dolutegravir or darunavir in combination with zidovudine or tenofovir to treat HIV. N Engl J Med. 2021;385:330-341. doi:10.1056/NEJMoa2101609

12.

Shafran

Hughes

. Bictegravir/emtricitabine/tenofovir alafenamide in patients with genotype NRTI resistance [published online ahead of print August 16, 2022]. HIV Med. doi:10.1111/hiv.13376

13.

Birbeck

French

Perucca

, et al. Antiepileptic drug selection for people with HIV/AIDS: evidence-based guidelines from the ILAE and AAN. Epilepsia. 2012;53(1):207-214. doi:10.1111/j.1528-1167.2011.03335.x