Red Man Syndrome is a term used for an adverse event attributed to vancomycin infusion. Based on the presentation within white patients, the term is imprecise at best and can lead to suboptimal classification and management. Recent calls have advocated for the discontinuation of the use of this terminology. Pharmacists should take the lead in advocating for this change.
SivagnanamSDeleuD.Red man syndrome. Crit Care. 2003;7:119-120. doi:10.1186/cc1871
2.
First Nations Development Institute. Reclaiming native truth: a project to dispel America’s myths and misconceptions. Accessed May 3, 2021. https://rnt.firstnations.org/
AustinJPFosterBAEmpeyA.Replace red man syndrome with vancomycin flushing reaction. Hosp Pediatr. 2020;10:623-624. doi:10.1542/hpeds.2020-0125
5.
Alvarez-ArangoSYerneniSTangO, et al. Vancomycin hypersensitivity reactions documented in electronic health records. J Allergy Clin Immunol Pract. 2021;9:906-912. doi:10.1016/j.jaip.2020.09.027
6.
RybakMJLeJLodiseT, et al. Executive summary: therapeutic monitoring of vancomycin for serious methicillin-resistant Staphylococcus aureus infections: a revised consensus guideline and review of the American Society of Health-System Pharmacists, the Infectious Diseases Society of America, the Pediatric Infectious Diseases Society, and the Society of Infectious Diseases Pharmacists. J Pediatric Infect Dis Soc. 2020;9:281-284. doi:10.1093/jpids/piaa057
7.
BurrellCTsourounisCQuanD, et al. Impact of a pharmacist-driven protocol to improve drug allergy documentation at a university hospital. Hosp Pharm. 2013;48:302-307. doi:10.1310/hpj4804-302
8.
HarigARybarczykABenedettiAZimmermanJ.Clarification of drug allergy information using a standardized drug allergy questionnaire and interview. P T. 2018;43:480-504.
9.
GeibigCBMansurJMMedemaPGNoldEG.Pharmacy-controlled documentation of drug allergies. Am J Hosp Pharm. 1991;48:260-264.
10.
TrippDMBrownGR.Pharmacist assessment of drug allergies. Am J Hosp Pharm. 1993;50:95-98.
11.
American College of Clinical Pharmacy; PageRLIIHumeAL, et al. Interprofessional education: principles and application a framework for clinical pharmacy. Pharmacotherapy. 2009;29:879.
12.
BergeronLBoucherFD.Possible red-man syndrome associated with systemic absorption of oral vancomycin in a child with normal renal function. Ann Pharmacother. 1994;28:581-584. doi:10.1177/106002809402800505
13.
PolkRE.Red man syndrome. Ann Pharmacother. 1998;32:840. doi:10.1345/aph.16425
14.
KachrooSDaoTZabanehF, et al. Tolerance of vancomycin for surgical prophylaxis in patients undergoing cardiac surgery and incidence of vancomycin-resistant Enterococcus colonization. Ann Pharmacother. 2006;40:381-385. doi:10.1345/aph.1G565
15.
WaznyLDDaghighB.Desensitization protocols for vancomycin hypersensitivity. Ann Pharmacother. 2001;35:1458-1464. doi:10.1345/aph.1A002
