Incidence and Risk Factors for Development of Thrombocytopenia in Patients Treated With Linezolid for 7 Days or Greater

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References

Pfizer. Zyvox (linezolid) [package insert]. http://labeling.pfizer.com/showlabeling.aspx?id=649. Accessed April 2, 2017.

Lin

Tsai

et al . High frequency of linezolid-associated thrombocytopenia among patients with renal insufficiency. Int J Antimicrob Agents. 2006;28:345-351.

Wang

et al . High frequency of linezolid-associated thrombocytopenia and anemia among patients with endstage renal disease. Clin Infect Dis. 2006;42:66-72.

Chen

Guo

Cao

et al . Risk factors for thrombocytopenia in adult Chinese patients receiving linezolid therapy. Curr Ther Res Clin Exp. 2012;73:195-206.

Hanai

Matsuo

Ogawa

et al . A retrospective study of the risk factors for linezolid-induced thrombocytopenia and anemia. J Infect Chemother. 2016;22:536-542.

Nukui

Hatakeyama

Okamoto

et al . High plasma linezolid concentration and impaired renal function affect development of linezolid-induced thrombocytopenia. J Antimicrob Chemother. 2013;68:2128-2133.

Zhang

Zhou

et al . High frequency of thrombocytopenia in patients with acute-on-chronic liver failure treated with linezolid. Hepatobiliary Pancreat Dis Int. 2015;14:287-292.

Attassi

Hershberber

Alam

Zervos

MJ.

Thrombocytopenia associated with linezolid therapy. Clin Infect Dis. 2002;34:695-698.

Zhang

Liang

Chen

She

Comparative evaluation of thrombocytopenia in adult patients receiving linezolid or glycopeptides in a respiratory intensive care unit. Exp Ther Med. 2014;7:501-507.

10.

Curtis

BR.

Drug-induced immune thrombocytopenia: incidence, clinical features, laboratory testing, and pathogenic mechanisms. Immunohematology. 2014;30:55-65.

11.

Nishijo

Tsuji

Matsunaga

et al . Mechanism underlying linezolid-induced thrombocytopenia in a chronic kidney failure mouse model. J Pharmacol Pharmacother. 2017;8:8-13.

12.

Gerson

Kaplan

Bruss

et al . Hematologic effects of linezolid: summary of clinical experience. Antimicrob Agents Chemother. 2002;46:2723-2726.

13.

Bernstein

Trotta

Rector

Tjaden

Barile

AJ.

Mechanisms for linezolid-induced anemia and thrombocytopenia. Ann Pharmacother. 2003;37:517-520.

14.

Gonzalez-Del Castillo

Candel

Manzano-Lorenzo

et al . Predictive score of haematological toxicity in patients treated with linezolid. Eur J Clin Microbiol Infect Dis. 2017;36:1511-1517.