Abstract
Objective
To evaluate skeletal outcomes of the Alt-RAMEC protocol with facemask therapy compared with conventional rapid maxillary expansion (RME) in patients with cleft lip and/or palate.
Design
Systematic review and meta-analysis.
Setting
Data from international databases (PubMed, Embase, Scopus, Web of Science, CENTRAL, clinical trials registers, and Google Scholar) were analyzed.
Patients/Participants
Four studies involving approximately 136 patients with cleft lip and/or palate met inclusion criteria.
Interventions
Alternate RME and Constriction (Alt-RAMEC) followed by facemask protraction versus conventional expansion protocols.
Main Outcome Measure(s)
Cephalometric skeletal parameters (SNA, SNB, and ANB) and maxillary advancement.
Results
Alt-RAMEC with facemask produced a greater increase in SNA compared with controls (SMD 1.04; 95% CI 0.60-1.49; I² = 0%), while SNB changes were non-significant. ANB changes were variable across studies (I² = 96%). Certainty of evidence was moderate for SNA and low for SNB.
Conclusions
Alt-RAMEC combined with facemask therapy may yield greater anterior maxillary displacement in cleft lip and palate patients than conventional RME protocols, though evidence remains limited. Standardized multicenter studies with long-term follow-up are needed.
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References
Supplementary Material
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