Epidermolysis bullosa simplex (EBS) is a rare congenital disorder that presents with blistering of the skin from minimal shearing or pulling, making surgical care complex in terms of preventative measures and management. Literature is limited regarding cleft care in this unique patient population. We present a case report outlining a multidisciplinary cleft treatment plan with a focus on communication with the patient's family. Cleft lip and palate repair was performed using standard techniques and timing without complication, demonstrating that cleft lip and palate repairs can safely be performed in a patient with EBS.
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