Evaluation of Weight,Height,Body Mass Index,and Nutritional Status of Children With and Without Orofacial Cleft in Nigeria

Abstract

Objective

To compare the weight, height, BMI and nutritional status of patients with and without cleft lip and/or cleft palate (CLP).

Design

Cross-sectional study

Setting

Lagos University Teaching Hospital

Patients, participants

Patients with CLP and a control group of participants without CLP aged between 1 month and 6 years. All patients in the CLP group had not received surgical or nutritional intervention.

Outcome measures

Weight, height, BMI, their respective percentiles, and nutritional status according to the WHO 2006 growth curves of participants

Results

Patients with CLP (n = 60, 21 males, 39 females, mean age: 19.1 months) had significantly lower percentile weight and height compared to those of controls (n = 60, 26 females, mean age, 23.6 months) in univariate analyses (all p < 0.01). Multivariate linear regression revealed significant interactions with age group for weight. In addition, proportions of underweight and short stature were significantly higher in the CLP group compared to the control group (all p < 0.05), and these significant differences were dependent on the age group with between-group significant differences only in age groups less than 25 months.

Conclusions

Overall, patients with CLP had significantly lower weight, height, BMI and nutritional status than their unaffected peers, and these differences were dependent on age group. Significantly lower nutritional status was seen in patients with CLP up to 24 months of age, which highlights the need for early nutritional intervention in the management of CLP.

Keywords

weight height BMI nutritional status cleft lip and palate

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References

Oginni

Adenekan

. Prevention of oro-facial clefts in developing world. Ann Maxillofac Surg. 2012;2(2):163.

Shkoukani

Chen

Vong

. Cleft lip - a comprehensive review. Front Pediatr. 2013;1(1):53.

Agrawal

. Cleft palate repair and variations. Indian J Plast Surg. 2009;42(3):102.

Gosman

. Cleft lip and palate I: Embryology, Anatomy, Epidemiology and clinical assessment. Sel Readings Plast Surg. 2007;10(16):1-8.

Shkoukani

Lawrence

Liebertz

Svider

. Cleft palate: A clinical review. Birth Defects Res Part C - Embryo Today Rev. 2014;102(4):333-342.

Montagnoli

Barbieri

Bettiol

Marques

de Souza

. Growth impairment of children with different types of lip and palate clefts in the first 2 years of life: A cross-sectional study. J Pediatr (Rio J). 2005;81(6):461-465. doi:https://doi.org/10.2223/JPED.1420

Pandya

Boorman

. Failure to thrive in babies with cleft lip and palate. Br J Plast Surg. 2001;54(6):471-475. doi:https://doi.org/10.1054/bjps.2001.3618

Bowers

Mayro

Whitaker

Pasquariello

LaRossa

Randall

. General body growth in children with clefts of the lip, palate, and craniofacial structure. Scand J Plast Reconstr Surg Hand Surg. 1987;21(1):7-14. doi:https://doi.org/10.3109/02844318709083572

Crockett

Goudy

. Cleft lip and palate. Facial Plast Surg Clin North Am. 2014;22(4):573-586. doi:https://doi.org/10.1016/j.fsc.2014.07.002

10.

Egbunah

. Environmental and genetic risk factors of nonsyndromic and syndromic cleft lip and palate - A literature review. Ann Surg Educ. 2022;3(1):1-6. http://www.medtextpublications.com/open-access/environmental-and-genetic-risk-factors-of-nonsyndromic-and-syndromic-cleft-989.pdf

11.

Gallego

Iglesia-Altaba

Moreno

Rodríguez

. Long-term growth patterns in children born with cleft lip and/or palate. A systematic review. Nutr Hosp. 2021;38(2):410-417. doi:https://doi.org/10.20960/nh.03426

12.

Raynor

Rudolf

. Anthropometric indices of failure to thrive. Arch Dis Child. 2000;82(5):364-365. doi:https://doi.org/10.1136/adc.82.5.364

13.

Barker

. Early growth and cardiovascular disease. Arch Dis Child. 1999;80(4):305-307. doi:https://doi.org/10.1136/adc.80.4.305

14.

Rudolf

MCJ

Logan

. What is the long term outcome for children who fail to thrive? A systematic review. Arch Dis Child. 2005;90(9):925-931. doi:https://doi.org/10.1136/adc.2004.050179

15.

Blair

Nadin

Cole

, et al. Weight gain and sudden infant death syndrome: Changes in weight z scores may identify infants at increased risk. Arch Dis Child. 2000;82(6):462-469. doi:https://doi.org/10.1136/adc.82.6.462

16.

Nahai

Williams

Burstein

Martin

Thomas

. The management of cleft lip and palate: Pathways for treatment and longitudinal assessment. Semin Plast Surg. 2005;19(04):275-285. doi:https://doi.org/10.1055/s-2005-925900

17.

Shaw

Semb

Lohmander

, et al. Timing of primary surgery for cleft palate (TOPS): Protocol for a randomised trial of palate surgery at 6 months versus 12 months of age. BMJ Open. 2019;9(7):e029780. doi:https://doi.org/10.1136/bmjopen-2019-029780

18.

Beaumont

. A study into weight gain in infants with cleft lip/palate. Paediatr Care. 2008;20(6):20-23. doi:https://doi.org/10.7748/paed2008.07.20.6.20.c6626

19.

Miranda

Marques

De Barros

Arena

De Souza

. Weight, length, and body mass index growth of children under 2 years of age with cleft lip and palate. Cleft Palate-Craniofacial J. 2016;53(3):264-271. doi:https://doi.org/10.1597/14-003

20.

da Silva Freitas

Lopes-Grego

Dietrich

HLD

, et al. Weight gain in children with cleft lip and palate without use of palatal plates. Plast Surg Int. 2012;2012:1-4. doi:https://doi.org/10.1155/2012/973240

21.

Seth

McWilliams

. Weight gain in children with cleft palate from birth to two years. Cleft Palate J. 1988;25(2):146-150.

22.

World Health Organization. WHO Child Growth Standards: Length/height-for-age, weight-for-age, weight-for-length, weight-for-height and body mass index-for-age : Methods and development. Dev Med Child Neurol. 2006;51(12):1-336. doi:https://doi.org/10.1111/j.1469-8749.2009.03503.x

23.

Merck and Co. Calculators WHO Infant Weight for Age Percentiles (MSD Manual Professional Edition. MSD Manual Professional version. Published 2023. Accessed July 10, 2023. https://www.msdmanuals.com/professional/pages-with-widgets/clinical-calculators?mode=list

24.

25.

Scott Long

Laurie

. Using heteroscedasticity consistent standard errors in the linear regression model. Am Stat. 2010;54(3):217-224. http://www.jstor.org/stable/2685594

26.

Tungotyo

Atwine

Nanjebe

Hodges

Situma

. The prevalence and factors associated with malnutrition among infants with cleft palate and/or lip at a hospital in Uganda: A cross-sectional study. BMC Pediatr. 2017;17(1):1-7. doi:https://doi.org/10.1186/s12887-016-0775-7

27.

Egbunah

Adekunle

Adeyemo

. Knowledge of environmental and genetic risk factors for cleft lip and palate among dwellers of a suburban community in Nigeria. West Afr J Med. 2022;39(5):478-485. https://www.ajol.info/index.php/wajm/article/view/77443

28.

Becker

Svensson

Källén

. Birth weight, body length, and cranial circumference in newborns with cleft lip or palate. Cleft Palate-Craniofacial J Off Publ Am Cleft Palate-Craniofacial Assoc. 1998;35(3):255-261. doi:https://doi.org/10.1597/1545-1569_1998_035_0255_bwblac_2.3.co_2

29.

Reid

Reilly

Kilpatrick

. Sucking performance of babies with cleft conditions. Cleft Palate-Craniofacial J Off Publ Am Cleft Palate-Craniofacial Assoc. 2007;44(3):312-320. doi:https://doi.org/10.1597/05-173

30.

Britton

KFM

McDonald

Welbury

. An investigation into infant feeding in children born with a cleft lip and/or palate in the West of Scotland. Eur Arch Paediatr Dent Off J Eur Acad Paediatr Dent. 2011;12(5):250-255. doi:https://doi.org/10.1007/BF03262817

31.

Masarei

Sell

Habel

Mars

Sommerlad

Wade

. The nature of feeding in infants with unrepaired cleft lip and/or palate compared with healthy noncleft infants. Cleft Palate-Craniofacial J. 2007;44(3):321-328. doi:https://doi.org/10.1597/05-185

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