To investigate and compare the occurrence of previous spontaneous abortion among mothers of children with nonsyndromic oral clefts (NSOC) and mothers of children without NSOC; to understand if previous spontaneous abortion could be a risk factor for the occurrence of NSOC in subsequent pregnancies.
Design
Case-control study.
Setting
Nonsyndromic oral clefts is an important public health problem. In the context of investigating risk factors for the occurrence of this malformation, previous spontaneous abortion have been considered in the etiology at NSOC.
Participants
There were 1004 participants. In the case group 502 mothers of children with NSOC, and in the control group 502 mothers of children without NSOC or any other malformation or syndrome.
Interventions
A standardized questionnaire was utilized to interview the maternal history of spontaneous abortion.
Mean Outcome Measure:
The data were evaluated using descriptive statistics, and comparisons were performed using the Chi-square test, adopting a significance level of 5%.
Results
The prevalence of maternal history of spontaneous abortion was 16.3% in the case group and 15.9% in the control group. Comparing the groups there was no statistical difference (p-value = 0.93). Analyzing the occurrence of previous spontaneous abortion, separating the case group according to the type of cleft in the child, no statistical differences were observed when comparing these groups between them.
Conclusion
Maternal history of spontaneous abortion was not associated with NSOC, not representing an independent risk factor for NSOC in the Brazilian population.
FreitasJGaribDGOliveiraM, et al.Rehabilitative treatment of cleft lip and palate: Experience of the Hospital for Rehabilitation of Craniofacial Anomalies-USP (HRAC-USP)-Part 2: Pediatric Dentistry and Orthodontics. J Appli Oral Sci. 2012;20(2):268-281. doi:https://doi.org/10.1590/s1678-77572012000200024
2.
XuD-PQuW-dSunCCaoR-YLiuD-w, DuP-g. A study on environmental factors for nonsyndromic cleft lip and/or palate. J Craniofac Surg. Mar 2018;29(2):364-367. doi:https://doi.org/10.1097/SCS.0000000000004214
3.
LeslieEJMarazitaML. Genetics of cleft lip and cleft palate. Am J Med Genet C Semin Med Genet. Nov 2013;163C(4):246-258. doi:https://doi.org/10.1002/ajmg.c.31381
MengLBianZTorensmaRVon den HoffJ. Biological mechanisms in palatogenesis and cleft palate. J Dent Res. Jan 2009;88(1):22-33. doi:https://doi.org/10.1177/0022034508327868
6.
TolarovaMM. Global health issues related to cleft lip and palate: Prevention and treatment need to team together. Indian J Dent Res. Sep-Oct 2016;27(5):455-456. doi:https://doi.org/10.4103/0970-9290.195607
7.
CarlsonJCTaubMAFeingoldE, et al.Identifying genetic sources of phenotypic heterogeneity in orofacial clefts by targeted sequencing. Birth Defects Res. Jul 17 2017;109(13):1030-1038. doi:https://doi.org/10.1002/bdr2.23605
8.
SilvaCMde Moraes PereiraMCde QueirozTBdas NevesLT. Family history in non-syndromic orofacial clefts: Is there a pattern?Oral Dis.Nov 2022;28(8):2194-2203. doi:https://doi.org/10.1111/odi.13942
9.
GonzálezBSLópezMLRicoMAGarduñoF. Oral clefts: A retrospective study of prevalence and predisposal factors in the State of Mexico. J Oral Sci. Jun 2008;50(2):123-129. doi:https://doi.org/10.2334/josnusd.50.123
10.
SilvaCMde Moraes PereiraMCde QueirozTBdas NevesLT. Can parental consanguinity be a risk factor for the occurrence of nonsyndromic oral cleft. Eartly Hum Dev. Aug 2019;135:23-26. doi:https://doi.org/10.1016/j.earlhumdev.2019.06.005
11.
SeelanRSMukhopadhyayPPisanoMMGreeneRM. Developmental epigenetics of the murine secondary palate. ILAR J. 2012;53(3-4):240-252. doi:https://doi.org/10.1093/ilar.53.3-4.240
12.
LinYShuSTangS. A case-control study of environmental exposures for nonsyndromic cleft of the lip and/or palate in eastern Guangdong, China. Int J Pediatri Otorhinolaryngol. Mat 2014;78(3):545-550. doi:https://doi.org/10.1016/j.ijporl.2014.01.002
13.
BlancoRColomboASuazoJ. Maternal obesity is a risk factor for orofacial clefts: A meta-analysis. Bri J Oral Maxillofaci Surg. Oct 2015;53(8):699-704. doi:https://doi.org/10.1016/j.bjoms.2015.05.017
14.
SabbaghHJHassanMHAInnesNPElkodaryHMLittleJMosseyPA. Passive smoking in the etiology of non-syndromic orofacial clefts: a systematic review and meta-analysis. PloS One. Mar 11 2015;10(3):e0116963. doi:https://doi.org/10.1371/journal.pone.0116963
15.
SabbaghHJAlamoudiNMAbdulhameedFD, et al.Environmental risk factors in the etiology of nonsyndromic orofacial clefts in the western region of Saudi Arabia. Cleft Palate Craniofac J.2016;53(4):435-443. doi:https://doi.org/10.1597/14-136
16.
MartinelliMGirardiACuraF, et al.Non-syndromic cleft lip with or without cleft palate in Asian populations: Association analysis on three gene polymorphisms of the folate pathway. Arch Oral Biol. Jan 2016;61:79-82. doi:https://doi.org/10.1016/j.archoralbio.2015.10.019
17.
ReganLRaiR. Epidemiology and the medical causes of miscarriage. Baillieres Best Pract Res Clin Obstet Gynaecol. Oct 2000;14(5):839-854. doi:https://doi.org/10.1053/beog.2000.0123
18.
VolgstenHJanssonCDarjEStavreus-EversA. Women’s experiences of miscarriage related to diagnosis, duration, and type of treatment. Acta Obstet Gynecol Scand. Dec 2018;97(12):1491-1498. doi:https://doi.org/10.1111/aogs.13432
19.
QuFWuYZhuY-H, et al.The association between psychological stress and miscarriage: a systematic review and meta-analysis. Sci Rep. May 11 2017;7(1). doi:https://doi.org/10.1038/s41598-017-01792-3
World Health Organization. Making every baby count: audit and review of stillbirths and neonatal deaths; 2016.
22.
XuLFZhouXLQiW, et al.A case-control study of environmental risk factors for nonsyndromic cleft of the lip and/or palate in Xuzhou, China. Biomed Environ Sci. Jul 2015;28(7):535-538. doi:https://doi.org/10.3967/bes2015.076
23.
HaoYTianSJiaoX, et al.Association of parental environmental exposures and supplementation intake with risk of nonsyndromic orofacial clefts: A case-control study in Heilongjiang Province, China. Nutrients. Aug 27 2015;7(9):7172-7184.
YangJWangYWangX-yZhaoY-yWangJZhaoY-y. Adverse pregnancy outcomes of patients with history of first-trimester recurrent spontaneous abortion. Biomed Res Int. 2017;2017. doi:https://doi.org/10.1155/2017/4359424
27.
JaslowCRCarneyJLKuttehWH. Diagnostic factors identified in 1020 women with two versus three or more recurrent pregnancy losses. Fertill Sterill. Mar 1 2010;93(4):1234-1243. doi:https://doi.org/10.1016/j.fertnstert.2009.01.166
28.
AllisonJLSchustDJ. Recurrent first trimester pregnancy loss: Revised definitions and novel causes. Curr Opin Endocrinol Diabetes Obes. Dec 2009;16(6):446-450. doi:https://doi.org/10.1097/MED.0b013e3283327fc5
PatkiAChauhanN. An epidemiology study to determine the prevalence and risk factors associated with recurrent spontaneous miscarriage in India. J Obstet Gynaecol India. Oct 2016;66(5):310-315. doi:https://doi.org/10.1007/s13224-015-0682-0
31.
CorreiaLLRochaHALLeiteÁJM, et al.Spontaneous and induced abortion trends and determinants in the Northeast semiarid region of Brazil: A transversal series. Rev. Bras. Saude Mater. Infant. Jan-Mar 2018;18(1):123-132. doi.org/10.1590/1806-93042018000100006
32.
ChojentaCHarrisSReillyNForderPAustinM-PLoxtonD. History of pregnancy loss increases the risk of mental health problems in subsequent pregnancies but not in the postpartum. PloS One. Apr 14 2014;9(4). doi:https://doi.org/10.1371/journal.pone.0095038
33.
PinelesBLParkESametJM. Systematic review and meta-analysis of miscarriage and maternal exposure to tobacco smoke during pregnancy. Am J Epidemiol. Apr 1 2014;179(7):807-823. doi:https://doi.org/10.1093/aje/kwt334
34.
WangLYangYLiuF, et al.Paternal smoking and spontaneous abortion: A population-based retrospective cohort study among non-smoking women aged 20–49 years in rural China. J Epidemiol Community Health. Sep 2018;72(9):783-789. doi:https://doi.org/10.1136/jech-2017-210311
35.
ZhaoRWuYZhaoF, et al.The risk of missed abortion associated with the levels of tobacco, heavy metals and phthalate in hair of pregnant woman: a case control study in Chinese women. Medicine (Baltimore). Dec 2017;96(51). doi:https://doi.org/10.1097/MD.0000000000009388
36.
BonatiMBortolusRMarchettiFRomeroMTognoniG. Drug use in pregnancy: An overview of epidemiological (drug utilization) studies. Eur J Clon Pharmacol. 1990;38(4):325-328. doi:https://doi.org/10.1007/BF00315569
37.
DawJRHanleyGEGreysonDLMorganSG. Prescription drug use during pregnancy in developed countries: A systematic review. Pharmacoepidemiology Drug Saf. Sep 2011;20(9):895-902. doi:https://doi.org/10.1002/pds.2184
38.
KjaersgaardMISParnerETVestergaardM, et al.Prenatal antidepressant exposure and risk of spontaneous abortion–a population-based study. PloS One. Aug 28 2013:8. doi:https://doi.org/10.1371/journal.pone.0072095
39.
WigleDTArbuckleTETurnerMC, et al.Epidemiologic evidence of relationships between reproductive and child health outcomes and environmental chemical contaminants. J Toxicol Environ Health B Crit Rev. May 2008;11(5-6):373-517. doi:https://doi.org/10.1080/10937400801921320
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