This study aimed to evaluate the chronological age range associated with each stage of spheno-occipital synchondrosis (SOS) fusion in patients with cleft lip and palate compared to the noncleft group, using cone-beam computed tomography (CBCT) images.
Design
In this study, the degree of SOS fusion was assessed using a 4-stage scoring system on CBCT images of 190 individuals (92 patients with cleft lip and palate, 98 noncleft individuals). A χ2 test was performed to assess the correlation between age and fusion stage. The independent sample t tests were used to evaluate the differences in the mean values of the samples of each group and each sex, as well as the mean value of each stage (P < .05).
Results
The results showed that there was no significant difference in the timing of the SOS fusion stages between the patients with cleft palate and the noncleft group. Although the fusion process of SOS begins about one year earlier in females, the complete ossification occurs at the mean age of 18.5 for both sexes in the experimental group and the mean age of 19.0 in the noncleft group.
Conclusions
The present study found no differences in the fusion stages of the spheno-occipital synchondrosis between patients with cleft lip and palate and healthy individuals.
JafariAZareaKMehreganN. The prevalence of cleft lip and cleft palate and related risk factors among Iranian children from 2000 to 2016: a literature review. Int J Pediatr.2017;5(4):4687-4697.
5.
JahanbinAEslamiNHoseini ZarchHKobraviS. Comparative evaluation of cranial base and facial morphology of cleft lip and palate patients with normal individuals in cone beam computed tomography. J Craniofac Surg2015;26(3):785-788. https://doi.org/10.1097/scs.0000000000001361
6.
DahlE. Craniofacial morphology in congenital clefts of the lip and palate. An x-ray cephalometric study of young adult males. Acta Odontol Scand1970;28(Suppl 57):11 + .
7.
DahlEKreiborgSJensenBLFogh-AndersenP. Comparison of craniofacial morphology in infants with incomplete cleft lip and infants with isolated cleft palate. Cleft Palate J1982;19(4):258-266.
8.
ShiBLoseeJE. The impact of cleft lip and palate repair on maxillofacial growth. Int J Oral Sci2015;7(1):14-17. https://doi.org/10.1038/ijos.2014.59
9.
NieX. Cranial base in craniofacial development: developmental features, influence on facial growth, anomaly, and molecular basis. Acta Odontol Scand2005;63(3):127-135. https://doi.org/10.1080/00016350510019847
10.
YangJHChaBKChoiDSParkJHJangI. Time and pattern of the fusion of the spheno-occipital synchondrosis in patients with skeletal class I and class III malocclusion. Angle Orthod2019;89(3):470-479. https://doi.org/10.2319/052218-386.1
11.
ShirleyNRJantzRL. Spheno-occipital synchondrosis fusion in modern Americans. J Forensic Sci. 2011;56(3):580–585.
12.
PowellTVBrodieAG. CLOSURE OF THE SPHENO-OCCIPITAL SYNCHONDROSIS. Anat Rec. 1963;147:15–23.
13.
IngervallBThilanderB. The human sphenooccipital synchondrosis I. The time of closure appraised macroscopically. Acta Odontologica Scandinavica. 1972;30(3):349–356.
14.
HishamSFlavelAAbdullahNNoorMHMFranklinD. Quantification of spheno-occipital synchondrosis fusion in a contemporary Malaysian population. Forensic Sci Int2018;284:78-84. https://doi.org/10.1016/j.forsciint.2017.12.046
15.
CollGSakkaLBotellaCPham-DangNColletCZerahMArnaudEDi RoccoF. Pattern of closure of skull base synchondroses in Crouzon syndrome. World Neurosurg2018;109:e460-e467. https://doi.org/10.1016/j.wneu.2017.09.208
16.
DriessenCRijkenBFDoergaPNDremmenMHJoostenKFMathijssenIM. The effect of early fusion of the spheno-occipital synchondrosis on midface hypoplasia and obstructive sleep apnea in patients with Crouzon syndrome. J Craniomaxillofacial Surg2017;45(7):1069-1073. https://doi.org/10.1016/j.jcms.2017.03.024
KimJHJeongHGHwangJJLeeJHHanSS. The impact of reorienting cone-beam computed tomographic images in varied head positions on the coordinates of anatomical landmarks. Imaging Sci Dent2016;46(2):133-139. https://doi.org/10.5624/isd.2016.46.2.133
21.
SinanogluAKocasaracHDNoujeimM. Age estimation by an analysis of spheno-occipital synchondrosis using cone-beam computed tomography. Leg Med.2016;18:13-19. https://doi.org/10.1016/j.legalmed.2015.11.004
22.
FranklinDFlavelA. Brief communication: timing of spheno-occipital closure in modern Western Australians. Am J Phys Anthropol2014;153(1):132-138. https://doi.org/10.1002/ajpa.22399
23.
AbuhijlehEAydemirHToygar-MemikoğluU. Three-dimensional craniofacial morphology in unilateral cleft lip and palate. Journal of Oral Science. 2014;56(2):165–172.
24.
DriessenCRijkenBFDoergaPNDremmenMHJoostenKFMathijssenI. The effect of early fusion of the spheno-occipital synchondrosis on midface hypoplasia and obstructive sleep apnea in patients with Crouzon syndrome. Journal of Cranio-Maxillofacial Surgery. 2017;45(7):1069–1073.
25.
PowellTVBrodieA. Closure of the spheno-occipital synchondrosis. The Anatomical Record. 1963;147:15–23.
26.
HorswellBBGallupB V. Cranial base morphology in cleft lip and palate: a cephalometric study from 7 to 18 years of age. J Oral Maxillofac Surg. 1992;50(7):681–685.
27.
ValeFFranciscoILucasARoseiroACarameloFSobralA. Timing of spheno-occipital synchondrosis ossification in children and adolescents with cleft lip and palate: a retrospective case-control study. Int J Environ Res Public Health2020;17(23):8889. https://doi.org/10.3390/ijerph17238889
28.
BassedRBBriggsCDrummerOH. Analysis of time of closure of the spheno-occipital synchondrosis using computed tomography. Forensic Sci Int2010;200(1–3):161-164. https://doi.org/10.1016/j.forsciint.2010.04.009
LiuXChenZ. Effects of palate repair on cranial base and maxillary morphology in patients with unilateral complete cleft lip and palate. Cleft Palate Craniofac J.2018;55(10):1367-1374. https://doi.org/10.1177/1055665618768544
