Preliminary research was conducted to ascertain the potential for a thromboxane synthetase inhibitor (TSI) in preventing the early histopathologic and biochemical changes associated with impending dermal pressure injury. In the presence of dermal pressure over a bony prominence in greyhound dogs, a systemically administered TSI resulted in lower dermal levels of thromboxane A2 (TxA2) and an absence of histopathologic lesions when compared to dogs receiving a placebo. The results indicate a potentialfor TSIs as adjunctive therapy in the prevention of decubital ulcers by counteracting the TxA2-related vasoconstriction and thrombosis with their resultant ischemic necrosis of the skin.
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